Results 1 to 10 of about 4,088 (135)

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients [PDF]

Frontiers in Pharmacology
BackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab, Maha M. AlRasheed, Dana Bakheet, Abdulkareem AlMomen, Nouf AlAboud, Farhad Kamali   +5 more
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Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay [PDF]

BMC Pharmacology and Toxicology
Introduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis.
Yazun Jarrar, Mansour Almansour, Mansour Al-Sayed Ahmad , Belal O. Al-Najjar, Amin A. Al-Doaiss, Sireen Abdul Rahim Shilbayeh, Su-Jun Lee   +6 more
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The curious family of cytochrome P450 4F fatty acid ω-hydroxylases: recent developments in their function and relevance for human health [PDF]

Open Biology
Cytochrome P450 enzymes (CYP, P450) are indispensable for human health and catalyse a plethora of reactions contributing to the clearance of xenobiotics, steroid and bile acid biosynthesis, and the functionalization of vitamins in the human body.
Brisa Caroline Alves Chagas, Huiting Jia, Bjoern Brixius, Simone Brixius-Anderko   +3 more
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Targeting estrogen mediated CYP4F2/CYP4F11-20-HETE metabolic disorder decelerates tumorigenesis in ER+ breast cancer [PDF]

Biochemistry and Biophysics Reports
Purpose: As the most common subset of breast cancer (BC), estrogen receptor positive (ER+) BC accounting for 80% of cases, has become a global public health concern. The female hormone estrogen (E2) unequivocally drives ER + breast malignancies.
Juan Yang, Yin Li, Xiao Han, Tianjiao Li, Ding Li, Qiao Liu, Lizhong Yan, Fei Li, Xiaolin Pei, Ya Feng, Zhoujun Lin, Zhenkun Fu, Changjun Wang, Qiang Sun, Chenggang Li   +14 more
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Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke [PDF]

Medicina
Background and Objectives: The aim of this study was to evaluate the potential predictive value of VKORC1, CYP4F2, and GGCX polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS)
Silvina Iluţ, Valer Donca, Antonia Eugenia Macarie, Ştefan Cristian Vesa, Raluca Maria Pop, Vitalie Văcăraş, Diana Şipoş-Lascu, Ioana Cristina Bârsan, Lăcrămioara Perju-Dumbravă, Ovidiu Sorin Chiroban, Camelia Alexandra Coadă, Anca Dana Buzoianu   +11 more
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Integrated analysis identifies key genes underlying the bidirectional association between depression and renal failure [PDF]

Scientific Reports
Depression is a common psychiatric comorbidity in individuals with end-stage renal disease (ESRD). However, the underlying biological mechanisms and the precise relationship between depression and renal failure remain unclear. While interventions such as
Zhengqi Qiu, Yu Nie, Xu Lin, Jun Du, Juntao Kan, Emma Yun Zhi Huang   +5 more
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Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy [PDF]

Scientific Reports
Warfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China.
Defa Huang, Fangfang Xie, Shengpeng Xiao, Minyang Cai, Die Hu, Baodian Ling, Fangsheng Wang, Xuan Lin, Fangli Song, Qi Wang, Tianyu Zhong   +10 more
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Pharmacodynamic Modeling of Warfarin Dosing Algorithm for Cardiovascular Patients in Indonesia: A Tailored Method to Anticoagulation Therapy [PDF]

Drug Design, Development and Therapy
Norisca Aliza Putriana,1 Irma Rahayu Latarissa,2 Taofik Rusdiana,1 Tina Rostinawati,3 Mohammad Rizki Akbar4 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Department of ...
Putriana NA, Latarissa IR, Rusdiana T, Rostinawati T, Akbar MR   +4 more
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11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner [PDF]

Frontiers in Pharmacology
BackgroundR/S enantiomers of 11-hydroxyeicosatertraenoic acid (11-HETE) are formed from arachidonic acid by enzymatic and non-enzymatic pathways. 11-HETE is predominately formed by the cytochrome P450 1B1 (CYP1B1).
Sara A. Helal, Sara A. Helal, Ahmed A. El-Sherbeni, Ayman O. S. El-Kadi   +3 more
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The Effect of Rivaroxaban on CYP4F2 and Transcription Factors’ Activity in HUVECs

Applied Sciences, 2021
Interindividual variabilities between patients taking the anticoagulant rivaroxaban are a result of hepatic metabolism by CYP 450 enzymes. The objective of this study was to evaluate the impact of rivaroxaban on CYP4F2 and transcription factors’ activity
Ieva Ciapiene, Vacis Tatarunas, Agne Giedraitiene, Vaidotas Zvikas, Valdas Jakstas, Audrone Veikutiene, Ugne Meskauskaite, Ugne Venckyte, Audrius Pukalskas, Vaiva Lesauskaite   +9 more
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