Results 11 to 20 of about 4,157 (190)

Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact

BMC Molecular and Cell Biology, 2023
Background Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K.
Mahvash Farajzadeh-Dehkordi, Ladan Mafakher, Fatemeh Samiee-Rad, Babak Rahmani   +3 more
doaj   +3 more sources

NFLUENCE OF CYP4F2*3 ON RESPONSE TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME

Рациональная фармакотерапия в кардиологии, 2018
Background. Carriership of CYP4F2*3 (rs2108622, Val433Met) allelic variant can affect antiplatelet effect of clopidogrel, thus changing efficacy and safety of its standard dose.Aim.
K. B. Mirzaev, O. D. Konova, E. A. Grishina, K. A. Ryzhikova, Zh. A. Sozaeva, D. A. Andreev, M. Y. Gilyarov, D. A. Sychev   +7 more
doaj   +5 more sources

Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke [PDF]

BMC Medical Genetics, 2019
Background Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown.
Yuan Wu, Junjie Zhao, Yonglin Zhao, Tingqin Huang, Xudong Ma, Honggang Pang, Ming Zhang   +6 more
doaj   +3 more sources

EFFECT OF HIGH SALT ON RENAL NKCC2 IN CYP4F2 transgenic mice

Kidney Research and Clinical Practice, 2012
Cytochrome P450 4F2 (CYP4F2) catalyzes the ω-hydroxylation of arachidonic acid (AA) to 20-HETE. We previously generated a CYP4F2 transgenic (TG) mouse model, and demonstrated that overexpressed CYP4F2 elevates 20-HETE production and blood pressure in the
Yanyan Zhao, Jingjing Wu, Guangrei Lai
doaj   +2 more sources

Effect of CYP4F2 Polymorphisms on Ticagrelor Pharmacokinetics in Healthy Chinese Volunteers [PDF]

Frontiers in Pharmacology, 2022
Background: Ticagrelor belongs to a new class of P2Y12 receptor inhibitor that has been widely used for antiplatelet therapy. This study aimed to explore the effect of single nucleotide polymorphisms (SNPs) in metabolic enzymes, transporters, and other ...
Shanshan Nie, Kaifeng Chen, Kaifeng Chen, Chengxian Guo, Qi Pei, Chan Zou, Liangyuan Yao, Hongbo Yuan, Xia Zhao, Ran Xie, Xu He, Jie Huang, Guoping Yang   +12 more
doaj   +4 more sources

Pharmacogenomic Calling From Whole-Exome Sequencing in the Taiwanese Population-A Real-World Experience. [PDF]

Mol Genet Genomic Med
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Lin HH, Tsai MM, Chen HA, Hsu RH, Lin YS, Lin YL, Hsu C, Chien YH, Hwu WL, Lee NC.   +9 more
europepmc   +2 more sources

PharmVar GeneFocus: CYP4F2. [PDF]

Clin Pharmacol Ther
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain ...
Zubiaur P, Rodríguez-Antona C, Boone EC, Daly AK, Tsermpini EE, Khasawneh LQ, Sangkuhl K, Duconge J, Botton MR, Savieo J, Nofziger C, Whirl-Carrillo M, Klein TE, Gaedigk A.   +13 more
europepmc   +5 more sources

CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation [PDF]

Genes, 2020
Introduction: Atherosclerosis represents the process by which fibrous plaques are formed in the arterial wall, increasing its rigidity with a subsequent decrease in blood flow which can lead to several cardiovascular events. Seeing as vitamin K antagonists are involved in the pathogenesis of atherosclerosis, we decided to investigate whether ...
Stefan Cristian Vesa, Sonia Irina Vlaicu, Vitalie Vacaras, Sorin Crisan, Octavia Sabin, Sergiu Pasca, Adrian Pavel Trifa, Tamas Rusz-Fogarasi, Madalina Sava, Anca Dana Buzoianu   +9 more
openaire   +3 more sources

Empirical Drug Dosage Validates Pharmacogenomic Associations in All of Us. [PDF]

Clin Transl Sci
ABSTRACT The All of Us research program, a national longitudinal study conducted by the US National Institutes of Health, provides robust medical history, drug dosage and genomic data from a diverse population. All of Us offers an opportunity to discover novel correlations between drug dosage and genetic variation.
Matthias J, Falaguera MJ, Altman RB.
europepmc   +2 more sources

Efficacy and safety of warfarin therapy in patients with atrial fibrillation using genotype-guided dosing method

Zaporožskij Medicinskij Žurnal, 2022
The aim. To evaluate the efficacy and safety of warfarin (WF) therapy in patients with atrial fibrillation (AF) using pharmacogenetic dosing method at an anticoagulant monitoring office according to the results of a one-year prospective follow-up ...
M. Yu. Kolesnyk, Ya. M. Mykhailovskyi
doaj   +1 more source