Results 41 to 50 of about 4,157 (190)

Prevalence of rs2108622 (CYP4F2*3) Single Nucleotide Polymorphism – A Review

Journal of Natural Sciences and Engineering, 2021
Cardiovascular diseases are known to be treated with anticoagulants lifelong. Warfarin is one of the most commonly used medications for anticoagulation despite causing serious side effects in some patients. Different single nucleotide polymorphisms (SNPs) that have a role in the cytochrome P450 system can also affect the metabolism, as well as dosing ...
Selma Ziga, Hana Efendic, Larisa Besic
openaire   +1 more source

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Frontiers in Pharmacology, 2017
Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR.
J. E. Zhang, Kathrin Klein, Kathrin Klein, Andrea L. Jorgensen, Ben Francis, Ana Alfirevic, Stephane Bourgeois, Panagiotis Deloukas, Panagiotis Deloukas, Panagiotis Deloukas, Ulrich M. Zanger, Ulrich M. Zanger, Munir Pirmohamed   +12 more
doaj   +1 more source

Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Frontiers in Pharmacology, 2018
Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids ...
Junhao Li, Junhao Li, Hongxiao Zhang, Guixia Liu, Yun Tang, Yaoquan Tu, Weihua Li   +6 more
doaj   +1 more source

Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Molecules, 2018
Compound-3 is an oral monophosphate prodrug of gemcitabine. Previous data showed that Compound-3 was more potent than gemcitabine and it was orally active in a tumor xenograft model.
Yedong Wang, Yuan Li, Jia Lu, Huixin Qi, Isabel Cheng, Hongjian Zhang   +5 more
doaj   +1 more source

Multi‐site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos

Clinical and Translational Science, 2021
We conducted a multi‐site investigation of genetic determinants of warfarin dose variability in Latinos from the U.S. and Brazil. Patients from four institutions in the United States (n = 411) and Brazil (n = 663) were genotyped for VKORC1 c.‐1639G> A ...
Nihal El Rouby, Leiliane Rodrigues Marcatto, Karla Claudio, Letícia Camargo Tavares, Heidi Steiner, Marianna R. Botton, Steve A. Lubitz, Echo N. Fallon, Kevin Yee, Justin Kaye, Stuart A. Scott, Jason Karnes, Paulo Caleb Junior de Lima Santos, Jorge Duconge, Larisa H. Cavallari   +14 more
doaj   +1 more source

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases [PDF]

, 2016
Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level.
Conti, V, Corbi, G, De Lise, F, Di Donato, A, Filippelli, A, Izzo, V, Manzo, V, Russomanno, G   +7 more
core   +2 more sources

The prevalence of allelic variants of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Objective – to determine the allele frequency of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population. Materials and methods. We investigated 94 individuals at the age of 56 (47; 62) years (men – 23, women – 71) who underwent preventive ...
M. Yu. Kolesnik, Ya. M. Mykhailovskyi
doaj   +1 more source

Direct oral anticoagulants versus warfarin: is new always better than the old? [PDF]

, 2018
About 1.4 British million people are at risk of strokes due to non-valvular atrial fibrillation (AF) necessitating long-term anticoagulation. The vitamin K antagonist, warfarin, has a long half-life and narrow therapeutic range necessitating regular ...
Burn, John, Pirmohamed, Munir
core   +1 more source

FREQUENCIES OF POLYMORPHISMS IN THE CYTOCHROME’S P450 GENES OF WARFARIN TRANSFORMATION IN A EUROPEAN POPULATION OF EASTERN SIBERIA

Acta Biomedica Scientifica, 2018
Background. Genotypes of the cytochrome p450 isoform (CYP2C9 and CYP4F2) determine warfarin dose requirements. Frequencies of risk alleles and genotypes of CYP2C9 and CYP4F2 gene vary in different races and ethnic groups.Aim.
T. A. Bairova, E. A. Novikova, F. I. Belyalov, E. A. Shchedreeva, K. D. Ievleva, O. V. Kalyuzhnaya, O. A. Ershova, V. G. Pustozerov, O. A. Kovaleva, I. V. Rasputina, I. A. Noskova, T. V. Batogova, O. V. Kuznetsova, O. Yu. Bogoslova, S. I. Kolesnikov   +14 more
doaj   +1 more source

Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice

Kidney & Blood Pressure Research, 2021
Introduction: 20-Hydroxyeicosatetraenoic acid (20-HETE) is the metabolite of cytochrome P450, which modulates blood pressure by inhibiting renal sodium transport.
Jingjing Wu, Guangrui Lai, Fangjie Chen, Bijun Zhang, Yanyan Zhao   +4 more
doaj   +1 more source