Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium. [PDF]
PLoS ONE, 2015 Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators.
Roberta d'Emmanuele di Villa Bianca +10 more
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Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3 [PDF]
Communications Biology, 2022 Quantitative trait locus analysis of BALB/cN x C57BL/6 N intercross identifies cystathionine β-synthase as a previously unknown regulator of lymphangiogenesis by affecting VEGF-R2/VEGF-R3 expression in lymphatic endothelial cells.
Niloofar Hatami +7 more
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Emerging roles of cystathionine β-synthase in various forms of cancer [PDF]
Redox Biology, 2022 The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and kidney, while in other cancers (liver cancer and glioma) it becomes ...
Kelly Ascenção, Csaba Szabo
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Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition [PDF]
Biomolecules, 2020 Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (
Karim Zuhra +3 more
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Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia [PDF]
SAGE Open Medicine, 2020 Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres +10 more
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Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome [PDF]
NeurotherapeuticsDown syndrome (DS) is a genetic condition where the person affected by it is born with an additional – full or partial – copy of chromosome 21. DS presents with characteristic morphological features and is associated with a wide range of biochemical ...
Csaba Szabo
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Cystathionine β-synthase TtCbs1 from Tetrahymena thermophila catalyzes the synthesis of CdS quantum dots for methyl orange decolorization [PDF]
Applied and Environmental MicrobiologyCystathionine β-synthase (CBS) is a pivotal enzyme in the transsulfuration metabolic pathway, catalyzing the synthesis of H2S and cystathionine. These metabolites mediate stress responses and maintain cellular redox homeostasis.
Wenliang Lei +3 more
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The Reliable Detection of Homocysteine Using a Biosensor Based on Recombinant Cystathionine β-Synthase and Nanoporous Gold [PDF]
MicroorganismsGiven the essential roles of homocysteine (Hcy) and the interference of cysteine in effectively monitoring human health, this study proposed a synergistic effect strategy that combines the unique structural and functional properties of nanoporous gold ...
Zihan Huang +5 more
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Elevated homocysteine is negatively correlated with plasma cystathionine β‐synthase activity in givosiran‐treated patients [PDF]
JIMD ReportsGivosiran is a subcutaneously administered, liver‐targeted RNA interference (RNAi) therapeutic that has been approved for treating acute hepatic porphyria (AHP).
Mark A. Keibler +3 more
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Heme-Thiolate Perturbation in Cystathionine β‑Synthase by Mercury Compounds [PDF]
ACS Omega, 2021 Dayana Benchoam +5 more
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