Results 31 to 40 of about 1,104,559 (168)

Role of folate metabolizing genes and homocysteine in mothers of Down syndrome children

Tzu Chi Medical Journal, 2022
Objectives: Folates are essential nutrients required for the synthesis of DNA/RNA in cell division and segregation. Folates are reduced and methylated in the liver with the help of enzymes such as methylenetetrahydrofolate reductase (MTHFR), MTR MTRR ...
Amandeep Kaur, Anupam Kaur
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Prenatal maternal stress induces visceral hypersensitivity of adult rat offspring through activation of cystathionine--synthase signaling in primary sensory neurons

Molecular Pain, 2018
Irritable bowel syndrome is a disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that stressors presented during gestational periods could have
Hong-Jun Wang, Xue Xu, Rui-Hua Xie, Yun-Yun Rui, Ping-An Zhang, Xiao-Jue Zhu, Guang-Yin Xu   +6 more
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Endogenous H2S producing enzymes are involved in apoptosis induction in clear cell renal cell carcinoma

BMC Cancer, 2018
Background Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial.
Jan Breza, Andrea Soltysova, Sona Hudecova, Adela Penesova, Ivan Szadvari, Petr Babula, Barbora Chovancova, Lubomira Lencesova, Ondrej Pos, Jan Breza, Karol Ondrias, Olga Krizanova   +11 more
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Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Antioxidants, 2021
Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H2S)-releasing drugs, few have demonstrated the influence of endogenous H2S production.
Kevin M. Casin, John W. Calvert
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IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Cell Reports, 2017
Summary: Natural products have demonstrated utility in the clinic and can also act as probes to understand complex cellular pathways. Sanglifehrin A (SFA) is a mixed polyketide and non-ribosomal peptide synthase natural product with sub-nano-molar ...
Khian Hong Pua, Dylan T. Stiles, Mathew E. Sowa, Gregory L. Verdine   +3 more
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Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Journal of Pharmacological Sciences, 2011
.: Hydrogen sulfide (H2S) is an important signaling molecule in various mammalian cells and tissues. H2S is synthesized from l-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and ...
Shigeki Taniguchi, Ichiro Niki
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Expression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndrome

, 2015
Down syndrome is the most frequent aneuploidy in live births, with an overall frequency of 1/600-700 births. The overexpression of cystathionine β-synthase is thought to participate in the presentation of some phenotypes observed in Down syndrome ...
Olaya-C, M., J. Martínez, Pinilla, García-Robles, R., Ayala-Ramírez, P., Bermúdez, M.   +4 more
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Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background We aimed to investigate the regulatory effects of hydrogen sulfide (H2S) on carotid sinus baroreceptor sensitivity and its mechanisms. Methods and Results Male Wistar‐Kyoto rats and spontaneously hypertensive rats (SHRs) were used in the ...
Wen Yu, Ying Liao, Yaqian Huang, Selena Y. Chen, Yan Sun, Chufan Sun, Yuming Wu, Chaoshu Tang, Junbao Du, Hongfang Jin   +9 more
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Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Nature Communications, 2020
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui   +12 more
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Cystathionine β-Synthase Is Necessary for Axis Development in Vivo

Frontiers in Cell and Developmental Biology, 2018
The cystathionine ß-synthase (CBS) is a critical enzyme in the transsulfuration pathway and is responsible for the synthesis of cystathionine from serine and homocysteine. Cystathionine is a precursor to amino acid cysteine.
Shubhangi Prabhudesai, Chris Koceja, Anindya Dey, Shahram Eisa-Beygi, Noah R. Leigh, Resham Bhattacharya, Resham Bhattacharya, Priyabrata Mukherjee, Priyabrata Mukherjee, Priyabrata Mukherjee, Priyabrata Mukherjee, Ramani Ramchandran, Ramani Ramchandran, Ramani Ramchandran   +13 more
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