Results 21 to 30 of about 1,104,559 (168)

CBS promoter hypermethylation increases the risk of hypertension and stroke

Clinics, 2019
OBJECTIVES: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke.
Changyi Wang, Guodong Xu, Qi Wen, Xiaolin Peng, Hongen Chen, Jingwen Zhang, Shan Xu, Chunhui Zhang, Min Zhang, Jianping Ma, Zhaohui Hui, Guifu Wu, Min Ma   +12 more
doaj   +1 more source

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations [PDF]

, 2004
CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown.
John W. Scott, D. Grahame Hardie, Norman, D G, Miliea Anis, Scullion, Gillian A., Stewart, Greg, Scullion, Gillian A, Scott, J.W, Green, Kevin A, Simon A. Hawley, David G. Norman, Hawley, Simon A., Norman, David G., Gillian A. Scullion, Kevin A. Green, Scott, John W., Anis, Miliea, Green, Kevin A., Hardie, D. Grahame, Hawley, Simon A, Greg Stewart   +20 more
core   +1 more source

The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]

, 2009
Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Patel Pushpa, Carson Ray J, Patel, Pushpa, Heptinstall, John, Heptinstall, J, Wang, Rui, Carson, RJ, Rui Wang, John Heptinstall (7594472), Pushpa Patel, Carson, Ray J., Pushpa Patel (2697712), Heptinstall John, Rui Wang (52434), Vatish Manu, Vatish, M, Ray J Carson, Manu Vatish (187260), Wang Rui, Wang, R, Ray J. Carson (7594475), Vatish, Manu, Manu Vatish, John Heptinstall   +23 more
core   +1 more source

Association of selected genetic variants in CBS and MTHFR genes in a cohort of children with homocystinuria in Sri Lanka

Journal of Genetic Engineering and Biotechnology, 2022
Background Homocystinuria is an inherited, inborn error of homocysteine metabolism, which leads to the abnormal accumulation of homocysteine and its metabolites in blood and urine, resulting in various complications.
Nadeesha Samarasinghe, Dinithi Mahaliyanage, Sumadee De Silva, Eresha Jasinge, Nimal Punyasiri, H. W. Dilanthi   +5 more
doaj   +1 more source

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger

Cellular and Molecular Gastroenterology and Hepatology, 2018
Hydrogen sulfide (H2S) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this question.
Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa   +11 more
doaj   +1 more source

Understanding the Role of R266K Mutation in Cystathionine β-Synthase (CBS) Enzyme: An in Silico Study [PDF]

, 2021
Human cystathionine β-synthase (hCBS) is a Heme containing unique pyridoxal 5’-phosphate (PLP) dependent enzyme that catalyzes the bio-chemical condensation reactions in the transsulfuration pathway. The role of Heme in the catalytic activities of enzyme
Md. Ehesan, Ali, Aashish, Bhatt
core   +1 more source

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundZofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater extent than do other ACEIs.
Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild   +13 more
doaj   +1 more source

Health Functionalities of Betaine in Patients With Homocystinuria

Frontiers in Nutrition, 2021
Homocystinuria is a medical condition that can have widespread and harmful effects on multiple organ systems within the body. This disease is caused by a deficiency in one of the enzymes involved in the methionine metabolism pathway. One example would be
Chelsea Truitt, Wouter D. Hoff, Ratnakar Deole   +2 more
doaj   +1 more source

L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway [PDF]

, 2020
Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA
d'Emmanuele di Villa Bianca R., Cicala C., Gurgone D., Caiazzo E., Mitidieri E., Tramontano T., Sorrentino R., Mitidieri, Emma, Raffaella Sorrentino, Elisabetta Caiazzo, Danila Gurgone, Carla Cicala, Emma Mitidieri, CAIAZZO, ELISABETTA, Sorrentino, Raffaella, Roberta d'Emmanuele di Villa Bianca, Cicala, Carla, Gurgone, Danila, Teresa Tramontano, Tramontano, Teresa, d'Emmanuele di Villa Bianca, Roberta   +20 more
core   +1 more source

Homocystinuria and ocular complications – A review

Indian Journal of Ophthalmology, 2022
Homocystinuria is a rare metabolic inborn disorder caused due to dysfunctional cystathionine β-synthase (CBS) enzyme activity, thus resulting in elevated levels of methionine and homocysteine in the blood and urine.
Mehzabeen Rahman, Mohita Sharma, Pragati Aggarwal, Silkee Singla, Neha Jain   +4 more
doaj   +1 more source