Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase [PDF]
Redox Biology, 2020 Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez +11 more
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Enhanced expression of cystathionine β-synthase and cystathionine γ-lyase during acute cholecystitis-induced gallbladder inflammation. [PDF]
PLoS ONE, 2013 BACKGROUND: Hydrogen sulfide (H2S) has recently been shown to play an important role in the digestive system, but the role of endogenous H2S produced locally in the gallbladder is unknown.
Li Zhang +4 more
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Genes & Nutrition, 2018 Background The neurodegenerative disorder Alzheimer’s disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer’s
Anne Leiteritz +3 more
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Antioxidants, 2022 It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli.
Emma Mitidieri +12 more
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ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy. [PDF]
Int J Mol Sci, 2023 Endogenous hydrogen sulfide (H2S) produced by cystathionine β-synthase (CBS) and cystathionine-γ lyase (CSE) has emerged as a novel uterine vasodilator contributing to pregnancy-associated increases in uterine blood flow, which safeguard pregnancy health.
Bai J +8 more
europepmc +2 more sources
Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii. [PDF]
Comput Struct Biotechnol J, 2021 Cysteine plays a major role in the redox homeostasis and antioxidative defense mechanisms of many parasites of the phylum Apicomplexa. Of relevance to human health is Toxoplasma gondii, the causative agent of toxoplasmosis.
Fernández-Rodríguez C +11 more
europepmc +2 more sources
Distribution of two kinds of cystathionine γ-synthase in various bacteria [PDF]
FEMS Microbiology Letters, 1986 Abstract The substrate specificity of cystathionine γ-synthase (EC 4.2.99.9) in various bacteria was examined. O -Succinyl- l -homoserine was used preferably as a substrate by facultative anaerobic Gram-negative bacteria belonging to such genera as Escherichia, Klebsiella, Enterobacter, Citrobacter, Erwinia, Serratia, Proteus and Salmonella .
Hiroshi Kanzaki +3 more
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α-Helix in Cystathionine β-Synthase Enzyme Acts as Electron Reservoir [PDF]
, 2021 The modulation of electron density at the Pyridoxal 5-phosphate (PLP) catalytic center, due to charge transfer across the α-Helix-PLP interface, is the determining factor for the enzymatic activities in the human Cystathionine β-Synthase (hCBS) enzyme ...
Aashish , Bhatt +2 more
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Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. [PDF]
PLoS ONE, 2012 The cystathionine β-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of ...
Vinciane Régnier +15 more
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Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells
Biomolecules, 2023 This study was performed on human primary (WM115) and metastatic (WM266-4) melanoma cell lines developed from the same individual. The expression of proteins involved in L-cysteine metabolism (sulfurtransferases, and cystathionine β-synthase) and ...
Leszek Rydz +3 more
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