Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundZofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater extent than do other ACEIs.
Erminia Donnarumma +13 more
doaj +1 more source
Role of folate metabolizing genes and homocysteine in mothers of Down syndrome children
Tzu Chi Medical Journal, 2022 Objectives: Folates are essential nutrients required for the synthesis of DNA/RNA in cell division and segregation. Folates are reduced and methylated in the liver with the help of enzymes such as methylenetetrahydrofolate reductase (MTHFR), MTR MTRR ...
Amandeep Kaur, Anupam Kaur
doaj +1 more source
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]
, 2018 Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Astegno, A. +6 more
core +2 more sources
The FEBS Journal, 2020 Down syndrome (DS) is associated with significant perturbances in many morphological and biochemical features. Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter
C. Szabó
semanticscholar +1 more source
Health Functionalities of Betaine in Patients With Homocystinuria
Frontiers in Nutrition, 2021 Homocystinuria is a medical condition that can have widespread and harmful effects on multiple organ systems within the body. This disease is caused by a deficiency in one of the enzymes involved in the methionine metabolism pathway. One example would be
Chelsea Truitt +2 more
doaj +1 more source
The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39) [PDF]
, 2014 Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction.
Cai +54 more
core +1 more source
Enhanced expression of cystathionine β-synthase and cystathionine γ-lyase during acute cholecystitis-induced gallbladder inflammation. [PDF]
PLoS ONE, 2013 BACKGROUND: Hydrogen sulfide (H2S) has recently been shown to play an important role in the digestive system, but the role of endogenous H2S produced locally in the gallbladder is unknown.
Li Zhang +4 more
doaj +1 more source
Homocystinuria and ocular complications – A review
Indian Journal of Ophthalmology, 2022 Homocystinuria is a rare metabolic inborn disorder caused due to dysfunctional cystathionine β-synthase (CBS) enzyme activity, thus resulting in elevated levels of methionine and homocysteine in the blood and urine.
Mehzabeen Rahman +4 more
doaj +1 more source
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]
, 2016 Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya +7 more
core +1 more source
BMC Cancer, 2018 Background Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial.
Jan Breza +11 more
doaj +1 more source