Results 71 to 80 of about 34,415 (185)

A Lipid-Rich Gestational Diet Predisposes Offspring to Nonalcoholic Fatty Liver Disease: A Potential Sequence of Events [PDF]

, 2014
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, and it is increasing worldwide.
Hughes, Alexandria N., Oxford, Julia Thom   +1 more
core   +3 more sources

Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans

Genes & Nutrition, 2018
Background The neurodegenerative disorder Alzheimer’s disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer’s
Anne Leiteritz, Benjamin Dilberger, Uwe Wenzel, Elena Fitzenberger   +3 more
doaj   +1 more source

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide [PDF]

, 2018
BACKBROUND: COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway ...
Adcock, Ian, Caramori, Gaetano, Casolari, Paolo, Chung, Kian Fan, Halayko, Andrew J., Papi, Alberto, Perry, Mark M., Rempel, Karen Limbert, Tildy, Bernadett   +8 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via epigenetic regulation of the gene writer and eraser function

Physiological Reports, 2022
Ketone bodies (KB) serve as the food for mitochondrial biogenetics. Interestingly, probiotics are known to promote KB formation in the gut (especially those that belong to the Lactobacillus genus).
Mahavir Singh, Sathnur Pushpakumar, Yuting Zheng, Rubens P. Homme, Irina Smolenkova, Sri Prakash L. Mokshagundam, Suresh C. Tyagi   +6 more
doaj   +1 more source

The effects of hydrogen sulfide synthesis inhibition in lindane-induced seizures in rats: A behavioral and EEG study [PDF]

Archives of Biological Sciences, 2020
Lindane-induced seizure in rats is a model of refractory generalized epilepsy. Hydrogen sulfide (H2S) is a gasotransmitter with different physiological and pathological roles.
Šutulović Nikola, Rašić-Marković Aleksandra, Grubač Željko, Đurić Emilija, Hrnčić Dragan   +4 more
doaj   +1 more source

A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery [PDF]

, 2017
Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated.
Alexander, Stephen P.H., Donovan, J., Dunn, William R., Garle, M.J., Ralevic, Vera, Roberts, Richard E., Wong, P.S.   +6 more
core   +2 more sources

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

β₃ Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide

Antioxidants, 2022
It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli.
Emma Mitidieri, Annalisa Pecoraro, Erika Esposito, Vincenzo Brancaleone, Carlotta Turnaturi, Luigi Napolitano, Vincenzo Mirone, Ferdinando Fusco, Giuseppe Cirino, Raffaella Sorrentino, Giulia Russo, Annapina Russo, Roberta d’Emmanuele di Villa Bianca   +12 more
doaj   +1 more source