Results 51 to 60 of about 7,369 (184)

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers [PDF]

, 2013
Background Trypanosomatids of the genera Angomonas and Strigomonas live in a mutualistic association characterized by extensive metabolic cooperation with obligate endosymbiotic Betaproteobacteria.
Alves, João M.P., Buck, Gregory A., Camargo, Erney P., Costa-Martins, André G., da Silva, Flávia Maia, Klein, Cecilia C., Motta, Maria Cristina M., Sagot, Marie-France, Serrano, Myrna G., Teixeira, Marta M.G., Vasconcelos, Ana Tereza R.   +10 more
core   +5 more sources

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]

, 2016
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya, Hellmich, Mark R., Marcatti, Michela, Nagy, Péter, Szabo, Csaba, Szczesny, Bartosz, Wiktorowicz, John E., Zatarain, John R.   +7 more
core   +1 more source

Cystathionine .GAMMA.-lyase activity in the cephamycin C producer Streptomyces lactamdurans.

The Journal of Antibiotics, 1981
Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that ...
B A, Kern, E, Inamine
openaire   +3 more sources

Magnetic Resonance Spectroscopy of Cystathionine and 2-Hydroxyglutarate in Brain Tumors. [PDF]

NMR Biomed
Cystathionine and 2‐hydroxyglutarate were evaluated in 38 glioma patients with TE 97ms PRESS at 3T. Cystathionine level was significantly higher in IDH‐mutant 1p/19q‐codeleted gliomas than in IDH‐mutant non‐codeleted gliomas (p = 0.002). The sensitivity and specificity of the cystathionine measures with respect to 1p/19q status were 0.8 and 0.79, while
Choi C, Huynh M, Kovacs Z, Behof WJ, Pham W, Ganji SK, An Z, Patel TR, Maher EA, Berry JD, Mobley BC, Davis LT, McKnight CD, Pruthi S, Merrell RT, Mohler AC, Kelly PD, Thompson RC.   +17 more
europepmc   +2 more sources

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients. [PDF]

, 2016
Dialysis patients display a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity.
Amoresano, A, Cirillo, G, Di Nunzio, A, Fontanarosa, C, Ingrosso, D., Pane, F, Perna, AF, Pucci, P, Trepiccione, F, Vigorito, C, Zacchia, M   +10 more
core   +1 more source

Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

Gut and Liver, 2008
Background/Aims: Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions.
doaj   +1 more source

H2S biosynthesis and catabolism: new insights from molecular studies [PDF]

, 2017
Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO).
A Asimakopoulou, A Badiei, A Badiei, A Calderwood, A Jamroz-Wiśniewska, A Kalani, A Madurga, A Papapetropoulos, A Sun, AA Untereiner, AD Ang, AF Kamath, AF Perna, AF Perna, AK Mustafa, AL King, B Calenic, B Fox, B Gemici, B Gemici, B Geng, B Geng, B Qabazard, B Qabazard, B Szczesny, BD Paul, BJ Henriques, C Coletta, C Hine, C Hine, C Konrad, C Köhn, C Maestro de las Casas, C Steegborn, C Szabo, C Yang, CW Huang, D Liang, D Liao, DA Wing, DC Croteau-Chonka, DI Zafeiriou, DL Miller, DW Porter, DW Porter, E Albertini, E Grambow, E Lagoutte, EG Lynn, EG Mueller, EG Shesely, EM Bos, F Talaei, FL Zhao, G Chwatko, G Szabo, G Tang, G Tang, G Wang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Yang, G Zagli, G Zhang, GA Benavides, GD Yang, GK Kolluru, GV Velmurugan, H Duplain, H Jang, H Jurkowska, H Kabil, H Li, H Shi, H Zhang, HB Roman, HG Lee, HL Jiang, HS Jin, I Baiges, I Billaut-Laden, I Hirata, I Ishii, I Meo Di, I Ueki, J Cai, J Candela, J Ereño-Orbea, J Hamelet, J Hamelet, J Wang, J Wang, JB Vicente, JD Finkelstein, JG Vande Weghe, JJ Li, JL Meng, JL Wallace, JN Mayo, JT Brosnan, JW Calvert, JW Elrod, JW Horsman, K Eto, K Kondo, K Modis, K Módis, K Módis, K Ono, K Robert, K Wang, K Wilson, K Yao, KL Flannigan, KM Syhr, KN Maclean, KR Olson, KR Olson, L Chang, L Chen, L Gambari, L Li, L Li, L Li, L Li, L Miao, L Miao, L Wang, L Wang, L Xei, LA Harker, LL Pan, M Ackermann, M Goubern, M Liang, M Libiad, M Meier, M Nuño-Ayala, M Okomoto, M Pimentel, M Watanabe, M Whiteman, M Whiteman, M Whiteman, M Whiteman, M Whiteman, M Yang, MA Guzman, MD Fonseca, MH Stipanuk, MH Stipanuk, MK Thorson, MK Thorson, MM Cortese-Krott, MM Cortese-Krott, MP Gallegos-Arreola, MR Filipovic, MR Filipovic, MR Jackson, MW Budde, MY Ali, MY Tsai, N Endo, N Nagahara, N Nagahara, N Shibuya, N Weiss, O Kabil, O Kabil, O Kabil, O Kabil, O Zayachkivska, P Manna, P Nicholls, Peter Rose, Philip K. Moore, PK Yadav, PM Mrozikiewicz, PM Snijder, PS Ganapathy, Q Hu, QH Meng, R Baskar, R Ding, R Greiner, R Kodela, R Picton, R Tocmo, R Tocmo, R Wang, R Yang, RC Zanardo, RH Abeles, RN Carter, RS Beard, S Banu, S Bhattacharyya, S Dayal, S Dayal, S Gupta, S Huang, S Jain, S Jin, S Kundu, S Mani, S Pushpakumar, S Ramasamy, S Saha, S Sen, S Shastry, S Shi, S Xu, SH Cheung, SK Jain, SR Lentz, SY Wu, T Ida, T Itou, T Ivanciuc, T Krejcova, T Takahashi, TJ Lechuga, TM Hildbrant, TT Pan, TW Miller, U Sen, U Sen, U Sen, V Tiranti, V Vitvisky, VE Laubach, W Liu, W Qiao, W Wang, W Washtien, W Zhao, W Zhu, WA Pryor, WJ Cai, X Li, X Shen, X Shen, XH Wang, XQ Tang, XQ Tang, Y Gao, Y Hagiya, Y Hu, Y Kimura, Y Kumai, Y Li, Y Liu, Y Pei, Y Shen, Y Wei, Y Xu, Y Zhou, Yi Zhun Zhu, YJ Peng, Z Guo, Z Jiang, Z Pan, Z Wang, Z Zhang, ZL Clarke, ZZ Xie, ZZ Zhao   +272 more
core   +2 more sources

Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies [PDF]

Molecular Genetics and Metabolism, 2009
We report studies of six individuals with marked elevations of cystathionine in plasma and/or urine. Studies of CTH, the gene that encodes cystathionine gamma-lyase, revealed the presence among these individuals of either homozygous or compound heterozygous forms of a novel large deletion, p.Gly57_Gln196del, two novel missense mutations, c.589C>T (p ...
Kraus, Jan P., Hasek, Jindrich, Kozich, Viktor, Collard, Renata, Venezia, Sarah, Janosíková, Bohumila, Wang, Jian, Stabler, Sally P., Allen, Robert H., Jakobs, Cornelis, Finn, Christine T., Chien, Yin-Hsiu, Hwu, Wuh-Liang, Hegele, Robert A., Mudd, S. Harvey   +14 more
openaire   +6 more sources

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source