Results 81 to 90 of about 7,369 (184)

Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? [PDF]

, 2015
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man ...
Moore, PK, Whiteman, Matthew
core   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

The role of H2S bioavailability in endothelial dysfunction [PDF]

, 2016
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from ...
Ahmed, A, Ichinose, F, Papapetropoulos, A, Szabo, C, Wang, R, Whiteman, M   +5 more
core   +1 more source

Influence of sex hormones on DNA content and cystathionine-γ-lyase expression in rat myocardium

Zaporožskij Medicinskij Žurnal, 2017
Till now sexual features of cystathionine-γ-lyase/H2S system functioning in heart and its relationship to DNA content in myocardial cells nuclei depending on the level of sex hormones.
A. V. Melnik , N. V. Zaichko, I. L. Chereshnyuk, О. А. Khodakіvskyi, O. А. Haiduk   +4 more
doaj   +1 more source

Cystathionine γ‐lyase expression during avian embryogenesis

Journal of Anatomy, 2009
AbstractCystathionine γ‐lyase (CSE) is a key enzyme in the trans‐sulphuration pathway for the biosynthesis of cysteine from methionine and catalyses the hydrolysis of cystathionine into cysteine. It has been reported to be expressed in mammalian liver and kidney but so far no comprehensive developmental expression analysis of CSE has been available. We
Krück, Stefanie, Mittapalli, Venugopal Rao, Pröls, Felicitas, Scaal, Martin   +3 more
openaire   +4 more sources

Toxic Tear Gas 2‐Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure

Drug Testing and Analysis, Volume 18, Issue 1, Page 74-84, January 2026.
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression

Frontiers in Pharmacology, 2020
ObjectiveExcess of fructose consumption is related to life-treating conditions that affected more than a third of the global population. Therefore, to identify a newer therapeutic strategy for the impact prevention of high fructose injury in age-related ...
Yaroslav Pavlovskiy, Antonina Yashchenko, Oksana Zayachkivska   +2 more
doaj   +1 more source

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes [PDF]

, 2015
Our investigation showed that hepatocytes isolated from cysteine dioxygenase knockout mice (Cdo1(−/−)) had lower levels of hypotaurine and taurine than Cdo1(+/+) hepatocytes. Interestingly, hypotaurine accumulates in cultured wild-type hepatocytes.
Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, Martha H. Stipanuk   +3 more
core   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source