Results 11 to 20 of about 7,579 (227)

Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids [PDF]

Antioxidants
Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the
Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K. Thanki, Walter A. Koltun, Gregory S. Yochum, Irina V. Pinchuk, Celia Chao, Mark R. Hellmich, Katalin Módis   +10 more
doaj   +4 more sources

Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study [PDF]

Transplantation Direct
Background. Hydrogen sulfide (H2S) produced endogenously by the CTH gene-encoded cystathionine gamma-lyase protects from renal ischemia–reperfusion injury in preclinical models.
Matthieu Halfon, MD, Raffaella Emsley, Thomas Agius, PhD, Arnaud Lyon, Sébastien Déglise, MD, Manuel Pascual, MD, Korkut Uygun, PhD, Heidi Yeh, MD, Leonardo V. Riella, MD, PhD, James F. Markmann, MD, PhD, Pierre-Yves Bochud, MD, Dela Golshayan, MD, PhD, Alban Longchamp, MD, PhD, the Swiss Transplant Cohort Study   +13 more
doaj   +3 more sources

Cystathionine gamma-lyase as an inflammatory factor and its link with immune inflammation in hepatitis B virus-related liver disease [PDF]

Scientific Reports
We aimed to explore the effectiveness of CTH as a serum inflammation biomarker for HCC. Enzyme-linked immunosorbent assay was used to detect serum levels of CTH, interleukin-6 (IL-6), C-reactive protein (CRP), and IL-10.
Chao Jin, Bobin Hu, Hongyu Liu, Rongming Wang, Jianning Jang, Minghua Su   +5 more
doaj   +4 more sources

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]

PLoS ONE, 2016
Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis.
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia   +7 more
doaj   +4 more sources

Cystathionine gamma lyase and hydrogen sulfide: new players in orthodontic root resorption. [PDF]

Ann Transl Med, 2020
Holliday LS, Dolce C.
europepmc   +5 more sources

Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury. [PDF]

Sci Rep, 2016
Hydrogen sulfide (H2S) is known to act protectively during renal ischemia/reperfusion injury (IRI). However, the role of the endogenous H2S in acute kidney injury (AKI) is largely unclear.
Markó L, Szijártó IA, Filipovic MR, Kaßmann M, Balogh A, Park JK, Przybyl L, N'diaye G, Krämer S, Anders J, Ishii I, Müller DN, Gollasch M.   +12 more
europepmc   +7 more sources

Cystathionine gamma lyase aggravates orthodontic root resorption in mice. [PDF]

Ann Transl Med, 2019
This study aimed to determine the contribution of cystathionine gamma lyase (CSE) to physiological and orthodontic root resorption in mice.Mice genetically deficient in the CSE (CSE-/-), the dominant hydrogen sulfide (H2S)-generating enzyme in osteoclast were used in this study.
Lu C, Chen L, Hua Y.
europepmc   +4 more sources

Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair [PDF]

Cell Communication and Signaling, 2023
Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao, Ting Yang, Meng-Yao Zheng, Peinan Zhao, Li-Ya An, Yu-Xing Qi, Ke-Qian Yi, Peng-Cheng Zhang, Da-Li Sun   +8 more
doaj   +2 more sources

Inhibition of cystathionine‐gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles [PDF]

Acta Physiologica, 2023
AbstractAimIn extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles.MethodsIntracerebral arterioles were isolated from wild ...
Maria Peleli, Kristina S. Lyngsø, Frantz Rom Poulsen, Pernille Hansen, Andreas Papapetropoulos, Jane Stubbe   +5 more
openalex   +5 more sources

Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors. [PDF]

Anticancer Res, 2021
Testicular cancer constitutes 1.0% of male cancer and typically carries a good prognosis. As far as we are aware, the role for hydrogen sulfide in testicular cancer and the level of hydrogen sulfide-synthesizing enzyme have never been addressed. Here we examined cystathionine gamma-lyase (CSE) expression in several germ-cell testicular tumors.Tissue ...
Ozluk E, Patel S, Coppola D, Ghali G, Cotelingam JD, Kevil CG, Shackelford RE.   +6 more
europepmc   +4 more sources