Results 41 to 50 of about 7,579 (227)
The Role of Hydrogen Sulfide in Plaque Stability
Antioxidants, 2022 Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute ...
Qian Lin, Bin Geng
doaj +1 more source
Cystathionine gamma-lyase expression is regulated by exogenous hydrogen peroxide in the mammalian cells. [PDF]
Gene Expr, 2012 Wang M, Guo Z, Wang S.
europepmc +2 more sources
Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells [PDF]
Cardiovascular Research, 2010 Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension. The current study compared proliferation of smooth muscle cells derived from CSE gene knockout mice (SMCs-KO) with that of wild-type mice (SMCs-WT).Cell proliferation was assessed by ...
Guangdong, Yang +5 more
openaire +2 more sources
Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies [PDF]
Molecular Genetics and Metabolism, 2009 We report studies of six individuals with marked elevations of cystathionine in plasma and/or urine. Studies of CTH, the gene that encodes cystathionine gamma-lyase, revealed the presence among these individuals of either homozygous or compound heterozygous forms of a novel large deletion, p.Gly57_Gln196del, two novel missense mutations, c.589C>T (p ...
Kraus, Jan P. +14 more
openaire +6 more sources
Hydrogen sulfide pathway and skeletal muscle: an introductory review. [PDF]
, 2018 The presence of the H2 S pathway in skeletal muscle (SKM) has recently been established. SKM expresses the three constitutive H2 S-generating enzymes in animals and humans, and it actively produces H2 S.
Armogida Chiara +2 more
core +4 more sources
Redox Biology, 2020 Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez +11 more
doaj +1 more source
Redox Biology, 2022 Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-lyase (
Masahiro Akiyama +11 more
doaj +1 more source
Scientific Reports, 2021 Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the ...
Ann-Yae Na +8 more
doaj +1 more source
Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis
eLife, 2021 A fundamental challenge in human immunodeficiency virus (HIV) eradication is to understand how the virus establishes latency, maintains stable cellular reservoirs, and promotes rebound upon interruption of antiretroviral therapy (ART).
Virender Kumar Pal +6 more
doaj +1 more source
The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]
, 2009 Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Carson, Ray J. +4 more
core +5 more sources