Results 1 to 10 of about 31,925 (326)
Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians [PDF]
Biology, 2021 The evolutionary aspects of cystatins are greatly underexplored in early-emerging metazoans. Thus, we surveyed the gene organization, protein architecture, and phylogeny of cystatin homologues mined from 110 genomes and the transcriptomes of 58 basal ...
Pavla Bartošová-Sojková +10 more
doaj +8 more sources
Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates. [PDF]
PLoS ONE, 2014 Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the ...
Patrícia de Sousa-Pereira +5 more
doaj +3 more sources
Cystatins: unravelling the biological implications for neuroprotection [PDF]
Archives of Medical Science, 2023 Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental, and clinical studies concerning cystatin C suggest it plays
Bartłomiej Stańczykiewicz +3 more
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The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship [PDF]
BMC Evolutionary Biology, 2008 Background Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases
Diaz Isabel, Martinez Manuel
doaj +5 more sources
Type 2 Cystatins and Their Roles in the Regulation of Human Immune Response and Cancer Progression [PDF]
Cancers (Basel), 2023 Simple Summary Type 2 cystatins are a group of small secreted protease inhibitors that regulate cysteine protease cathepsins and legumain. These enzymes regulate important cellular processes that are linked to the immune response and tumor progression ...
Zijun Zhang, F. Zhan
europepmc +2 more sources
Cystatins from the Human Liver Fluke Opisthorchis viverrini: Molecular Characterization and Functional Analysis [PDF]
Pathogens, 2023 A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc +6 more
doaj +2 more sources
Cystatins in Immune System [PDF]
Journal of Cancer, 2012 Cystatins comprise a large superfamily of related proteins with diverse biological activities. They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in recent years some alternative functions for cystatins have been ...
Špela Magister, J. Kos
semanticscholar +4 more sources
Cysteine proteinases and cystatins [PDF]
Brazilian Archives of Biology and Technology, 2003 This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests.
Adeliana S. Oliveira +2 more
doaj +5 more sources
Parasites & Vectors, 2015 Background Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in
Luís Fernando Parizi +8 more
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Biomolecular Concepts, 2011 Cystatins are small proteins, typically composed of 100–120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin ‘superfamily’.
Esposito Veronica, Temussi Piero A.
doaj +4 more sources