Results 1 to 10 of about 11,945 (263)

Cystatins from the Human Liver Fluke Opisthorchis viverrini: Molecular Characterization and Functional Analysis [PDF]

Pathogens, 2023
A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc, Rudi Grams, Sinee Siricoon, Nanthawat Kosa, Dawid Krenc, Wansika Phadungsil, Pongsakorn Martviset   +6 more
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Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and Fallopia japonica Extract: An In Vitro Study [PDF]

Biomedicines
Background/Objectives: Gingipains produced by P. gingivalis have been shown to be directly related to periodontal tissue degradation and are significant molecular targets in therapy of periodontitis.
Maciej Siewiński, Maciej Dobrzyński, Krzysztof Gołąb, Maciej Janeczek, Łukasz Nieradko, Barbara Bażanów, Andrzej Rapak, Marius Boariu, Stefan-Ioan Stratul, Alla Belova, Sorina Mihaela Solomon, Renata Samulak, Monika Machoy   +12 more
doaj   +2 more sources

Cystatins: unravelling the biological implications for neuroprotection [PDF]

Archives of Medical Science, 2023
Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental, and clinical studies concerning cystatin C suggest it plays
Bartłomiej Stańczykiewicz, Mateusz Łuc, Maciej Banach, Agnieszka Zabłocka   +3 more
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Host-Directed Therapies Based on Protease Inhibitors to Control Mycobacterium tuberculosis and HIV Coinfection [PDF]

Microorganisms
Despite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide.
Manoj Mandal, David Pires, José Miguel Azevedo-Pereira, Elsa Anes   +3 more
doaj   +2 more sources

The Acari Hypothesis, V: deciphering allergenicity [PDF]

Frontiers in Allergy
The Acari Hypothesis posits that acarians, i.e., mites and ticks, are operative agents of allergy. It derived from observations that allergens are molecular elements of acarians or acarian foodstuffs.
Andrew C. Retzinger, Gregory S. Retzinger   +1 more
doaj   +2 more sources

Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians

Biology, 2021
The evolutionary aspects of cystatins are greatly underexplored in early-emerging metazoans. Thus, we surveyed the gene organization, protein architecture, and phylogeny of cystatin homologues mined from 110 genomes and the transcriptomes of 58 basal ...
Pavla Bartošová-Sojková, Jiří Kyslík, Gema Alama-Bermejo, Ashlie Hartigan, Stephen D. Atkinson, Jerri L. Bartholomew, Amparo Picard-Sánchez, Oswaldo Palenzuela, Marc Nicolas Faber, Jason W. Holland, Astrid S. Holzer   +10 more
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Cathepsins and Their Endogenous Inhibitors in Host Defense During Mycobacterium tuberculosis and HIV Infection

Frontiers in Immunology, 2021
The moment a very old bacterial pathogen met a young virus from the 80’s defined the beginning of a tragic syndemic for humanity. Such is the case for the causative agent of tuberculosis and the human immunodeficiency virus (HIV).
Elsa Anes, José Miguel Azevedo-Pereira, David Pires   +2 more
doaj   +1 more source

Comparative analysis of cystatin superfamily in platyhelminths. [PDF]

PLoS ONE, 2015
The cystatin superfamily is comprised of cysteine proteinase inhibitors and encompasses at least 3 subfamilies: stefins, cystatins and kininogens. In this study, the platyhelminth cystatin superfamily was identified and grouped into stefin and cystatin ...
Aijiang Guo
doaj   +1 more source

Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

Frontiers in Immunology, 2021
Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires, Marta Calado, Tomás Velez, Manoj Mandal, Maria João Catalão, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet, José Miguel Azevedo-Pereira, Elsa Anes   +9 more
doaj   +1 more source

Top-Down Proteomics of Human Saliva Highlights Anti-inflammatory, Antioxidant, and Antimicrobial Defense Responses in Alzheimer Disease

Frontiers in Neuroscience, 2021
Alzheimer disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death.
Cristina Contini, Alessandra Olianas, Simone Serrao, Carla Deriu, Federica Iavarone, Federica Iavarone, Mozhgan Boroumand, Alessandra Bizzarro, Alessandra Lauria, Gavino Faa, Massimo Castagnola, Irene Messana, Barbara Manconi, Carlo Masullo, Tiziana Cabras   +14 more
doaj   +1 more source