Results 71 to 80 of about 11,945 (263)
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani +3 more
wiley +1 more source
The role of cystatin C as a proteasome inhibitor in multiple myeloma [PDF]
, 2020 Yijing Jiang +7 more
openalex +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
BMC Biology, 2008 Background In pathogens, certain genes encoding proteins that directly interact with host defences coevolve with their host and are subject to positive selection.
Purisima Enrico O +7 more
doaj +1 more source
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Performance of creatinine and cystatin C-based equations for GFR estimation in children with pre-dialysis chronic kidney disease. [PDF]
, 2022 Lesa Dawman +3 more
openalex +1 more source
A five-residue motif for the design of domain swapping in proteins
Nature Communications, 2019 Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani +6 more
doaj +1 more source
BMC Evolutionary Biology, 2008 Background Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases
Diaz Isabel, Martinez Manuel
doaj +1 more source
Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on
Acta Ophthalmologica, EarlyView.Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse +4 more
wiley +1 more source