Results 71 to 80 of about 116 (116)

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study

Experimental Physiology, EarlyView.
Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger, Alexandra Brahmer, Tobias Ehlert, Suzan Botzenhardt, Alfonso De Falco, Birgit Enders, Patricia S. Hähnel, Achim Heintz, Carl C. Schimanski, Thomas Kindler, Perikles Simon   +10 more
wiley   +1 more source

Diffusion Tensor Imaging (DTI) as a Non‐Invasive Tool for Assessing Pediatric Kidney Transplants: A Feasibility Study

Pediatric Transplantation, Volume 29, Issue 5, August 2025.
Our study demonstrates the feasibility of using diffusion tensor imaging (DTI) to evaluate pediatric kidney transplants. Significant differences in fractional anisotropy (FA) and track length were observed between transplanted and healthy kidneys, reflecting altered microstructural organization.
Suraj D. Serai, Tatiana Morales, Daniel Vossough, Sandra Amaral, Hansel J. Otero, Bernarda Viteri Baquerizo   +5 more
wiley   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.
Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Liver‐Directed Gene Therapy Mitigates Early Nephropathy in Murine Glycogen Storage Disease Type Ia

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Nephropathy is a complication of glycogen storage disease type Ia (GSD‐Ia), a metabolic disorder caused by pathogenic variants in glucose‐6‐phosphatase‐α (G6Pase‐α or G6PC1). While maintaining blood glucose homeostasis can delay the progression of renal disease in GSD‐Ia, the benefits of liver‐directed G6PC1 gene therapy on nephropathy remain ...
Cheol Lee, Kunal Pratap, Lisa Zhang, Hung Dar Chen, Irina Arnaoutova, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou   +7 more
wiley   +1 more source

Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality

Journal of Internal Medicine, Volume 298, Issue 1, Page 2-15, July 2025.
Abstract Background and Objectives This population‐based study explores associations of fibroblast growth factor 21 (FGF21), a key modulator of processes linked to protein metabolism, with protein intake and muscle mass, and their relationships with all‐cause mortality.
Adrian Post, Wendy A. Dam, Dion Groothof, Casper F. M. Franssen, Stephan J. L. Bakker, Robin P. F. Dullaart   +5 more
wiley   +1 more source

Changes in Serum Proteomic Profiles at Different Stages of Pregnancy Toxemia in Goats

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background In human medicine, serum proteome profiles are used to differentiate metabolic diseases and evaluate their pathophysiology. Understanding the serum proteome profiles of goats with pregnancy toxemia might help identify the proteomes and pathways responsible for the development of this disease and improve diagnosis and treatment ...
Murat Uztimür, Cennet Nur Ünal, Gürler Akpınar   +2 more
wiley   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 12, Issue 21, June 5, 2025.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Disease‐specific neuropathological alterations of the locus coeruleus in Alzheimer's disease, Down syndrome, and Parkinson's disease

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION The locus coeruleus (LC), the brain's primary source of noradrenaline (NA), undergoes early neurodegeneration in Parkinson's disease (PD), Alzheimer's diseases (AD), and Down syndrome (DS); however, differences have not been examined in parallel.
Marta Fructuoso, Yannick Vermeiren, Susana Boluda, Lev Stimmer, René A. J. Crans, Laura Xicota, Uli Eisel, Natalia Orti Casan, Philippe Bun, Charles Duyckaerts, Jean‐Maurice Delabar, Andre Strydom, Debby Van Dam, Mara Dierssen, Peter De Deyn, Marie‐Claude Potier   +15 more
wiley   +1 more source

Development of a plasma biomarker diagnostic model as a screening strategy for Alzheimer's disease in older inpatients

Brain‐X, Volume 3, Issue 2, June 2025.
Early diagnosis of Alzheimer's disease (AD) is a challenge because of the invasive nature of the lumbar puncture for cerebrospinal fluid and the high cost of positron emission tomography imaging barriers for their common use as biomarkers. This study aimed to evaluate the diagnostic potential of blood‐based neuro‐markers in this advanced age group ...
Xiaoxia Fang, Zhengke Liu, Xiaojun Kuang, Xiushi Ni, Xu Han, Xuejun Wen, Hong Xu   +6 more
wiley   +1 more source

On the measurement of glomerular filtration rate: An odyssey into the milieu intérieur

Experimental Physiology, EarlyView.
Anders Møller Greve, Anna Agnes Lytzen, Hrefna Sæunn Einarsdóttir, Michael Perch, Ronan M. G. Berg   +4 more
wiley   +1 more source