Results 1 to 10 of about 25,803 (305)

Cysteamine affects skeletal development and impairs motor behavior in zebrafish

Frontiers in Pharmacology, 2022
Cysteamine is a kind of feed additive commonly used in agricultural production. It is also the only targeted agent for the treatment of cystinosis, and there are some side effects in clinical applications. However, the potential skeletal toxicity remains
Chao Chen, Chao Chen, Yongliang Zheng, Yongliang Zheng, Xue Li, Xue Li, Li Zhang, Li Zhang, Kangyu Liu, Kangyu Liu, Sujie Sun, Sujie Sun, Zilin Zhong, Zilin Zhong, Hongmei Hu, Hongmei Hu, Fasheng Liu, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Yanlong Bi, Jianjun Chen, Jianjun Chen, Zigang Cao   +23 more
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Effect of Cystamine on Sperm and Antioxidant Parameters of Ram Semen Stored at 4 °C for 50 Hours [PDF]

Archives of Razi Institute, 2021
Physical and chemical changes caused by oxidative stress in the spermatozoa membrane can reduce spermatozoa function and even lead to death. Cystamine (NH2-CH2-CH2-SH, β-mercaptoethylamine) is a natural substance that modulates the endocrine and ...
J Jumintono, S Alkubaisy, D Yánez Silva, K Singh, A Turki Jalil, S Mutia Syarifah, Y Fakri Mustafa, I Mikolaychik, L Morozova, M Derkho   +9 more
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A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis

Orphanet Journal of Rare Diseases, 2021
Background Nephropathic cystinosis is a rare and severe metabolic disease leading to an accumulation of cystine in lysosomes which especially harms kidney function.
Christina van Stein, Sabrina Klank, Marianne Grüneberg, Chris Ottolenghi, Jürgen Grebe, Janine Reunert, Erik Harms, Thorsten Marquardt   +7 more
doaj   +2 more sources

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis [PDF]

Frontiers in Immunology
ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Mauro Piacentini, Delia Goletti   +14 more
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Thiol-SAM Concentration Effect on the Performance of Interdigitated Electrode-Based Redox-Free Biosensors [PDF]

Micromachines
Despite the direct, redox-free and simple detection non-faradaic impedimetric biosensors offer, considerable optimizations are required to enhance their performance for the detection of various biomarkers. Non-faradaic EIS sensors’ performance depends on
Abdulaziz K. Assaifan
doaj   +2 more sources

Adherence to Cysteamine Therapy Among Patients Diagnosed with Cystinosis in Saudi Arabia: A Prospective Cohort Study [PDF]

Pharmacy
Cystinosis is a rare autosomal recessive disorder in which cystine crystals accumulate within the cellular lysosomes, causing damage to multiple organs.
Reem Algasem, Nedaa Zainy, Essam Alsabban, Hamad Almojalli, Khalid Alhasan, Tariq Ali, Deiter Broering, Hassan Aleid   +7 more
doaj   +2 more sources

Mitigative role of cysteamine against unilateral renal reperfusion injury in Wistar rats [PDF]

Frontiers in Pharmacology
BackgroundIschemia-reperfusion injury (IRI) is unavoidable during kidney transplant and it is responsible for delayed or non-function after kidney transplantation. Cysteamine is the standard drug in the management of nephropathic cystinosis and its extra-
Babatunde Adebola Alabi, Babatunde Adebola Alabi, Okot-Asi Nku-Ekpang, Sodiq Kolawole Lawal, Ezekiel Olugbenga Iwalewa, Temidayo Omobowale, Richard Ajike, Ridwan Abiodun Lawal   +7 more
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Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients

Pharmaceutics, 2023
Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the
Sabrina Klank, Christina van Stein, Marianne Grüneberg, Chris Ottolenghi, Kerstin K. Rauwolf, Jürgen Grebe, Janine Reunert, Erik Harms, Thorsten Marquardt   +8 more
doaj   +1 more source

Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Cysteamine, an anti-oxidant aminothiol, is the treatment of choice for nephropathic cystinosis, a rare lysosomal storage disease. Cysteamine is a chemo-sensitization and radioprotection agent and its antitumor effects have been investigated ...
Toshio Fujisawa, Benjamin Rubin, Akiko Suzuki, Prabhudas S Patel, William A Gahl, Bharat H Joshi, Raj K Puri   +6 more
doaj   +1 more source

The cytotoxic effect of cysteamine and its combinations with various endodontic intracanal medications on fibroblast cells: in vitro study

Bulletin of the National Research Centre, 2023
Background This study was established to assess cysteamine’s cytotoxic effect alone and in combination with various intracanal medications on fibroblast cells, because the biocompatibility of intracanal medication is considered one of the main factors ...
Esraa Adel Mohamed Abd Elhameed ElGammal, Abeer Hashem Mahran, Salma Hassan El Ashry, Sara Hossam Fahmy   +3 more
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