Results 1 to 10 of about 7,905 (118)
International Journal of Pharmaceutics, 2020 Despite the high aqueous solubility of cysteamine, its unpleasant organoleptic properties, hygroscopicity, instability in solutions, and poor pharmacokinetic profile are the main drawbacks that limit its use for medical and cosmetic purposes. In this study, cysteamine-loaded liposomes were prepared using the ethanol injection method.
Hélène Greige-Gerges +1 more
exaly +5 more sources
Mechanisms for the Cytotoxicity of Cysteamine [PDF]
Toxicological Sciences, 2001 The major aim of this study was to quantitatively assess the contribution of H2O2 generation to the cytotoxicity induced by cysteamine. Cysteamine produces H2O2 at levels that correlate with its toxicity between 23 and 160 microM. A maximum of 6.9 microM H2O2 is generated by 625 microM cysteamine.
T M, Jeitner, D A, Lawrence
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A monoclinic polymorph of cysteamine hydrochloride [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 cloruro de 2-mercaptoetano-aminio), C(2)H(8)NS(+)·Cl(-), la sal de hidrocloruro de cisteamina, en contraste con el polimorfo triclínico previamente informado [Kim et al. (2002▶). Polyhedron, 21, 225-228], cristalizado en el sistema cristalino monoclínico.
Saeed Ahmad +2 more
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The specificity of cysteamine oxygenase
FEBS Letters, 1975 Oxidation of cysteamine to hypotaurine is catalyzed by cysteamine oxygenase (EC 1.13.11.19), a non-heme iron enzyme of large distribution [l-3] . A similar oxidation of cysteine to cysteine sulfinic acid has been reported to require a different oxygenase [4,.5]. Specificity of cysteamine oxygenase has been studied earlier in this laboratory by assaying
Cavallini, D. +5 more
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Myeloperoxidase-oxidase oxidation of cysteamine [PDF]
Biochemical Journal, 1988 Cysteamine oxidation was shown to be catalysed by nanomolar concentrations of myeloperoxidase in a peroxidase-oxidase reaction, i.e. an O2-consuming oxidation of a compound catalysed by peroxidase without H2O2 addition. When auto-oxidation of the thiol was prevented by the metal-ion chelator diethylenetriaminepenta-acetic acid, native, but not heat ...
B E, Svensson, S, Lindvall
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Spectroscopic Investigation of Cysteamine Dioxygenase
Biochemistry, 2020 Thiol dioxygenases are mononuclear non-heme FeII-dependent metalloenzymes that initiate the oxidative catabolism of thiol-containing substrates to their respective sulfinates. Cysteine dioxygenase (CDO), the best characterized mammalian thiol dioxygenase, contains a three-histidine (3-His) coordination environment rather than the 2-His-1-carboxylate ...
Rebeca L. Fernandez +4 more
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Radioprotective Efficacy of Cysteamine [PDF]
Acta Radiologica: Therapy, Physics, Biology, 1964 A, BOSE, S, BOSE, P, DE
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The Use of Cysteamine and Dimercaprol
Journal of International Medical Research, 1976 R D, Hughes +3 more
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A comprehensive approach to elucidating the pathophysiology of kidney fibrosis based on extracellular vesicle proteomics. [PDF]
Front PhysiolKim Y +12 more
europepmc +1 more source