Results 1 to 10 of about 18,039 (206)

Effect of Cystamine on Sperm and Antioxidant Parameters of Ram Semen Stored at 4 °C for 50 Hours [PDF]

Archives of Razi Institute, 2021
Physical and chemical changes caused by oxidative stress in the spermatozoa membrane can reduce spermatozoa function and even lead to death. Cystamine (NH2-CH2-CH2-SH, β-mercaptoethylamine) is a natural substance that modulates the endocrine and ...
J Jumintono, S Alkubaisy, D Yánez Silva, K Singh, A Turki Jalil, S Mutia Syarifah, Y Fakri Mustafa, I Mikolaychik, L Morozova, M Derkho   +9 more
doaj   +3 more sources

Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients

Pharmaceutics, 2023
Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the
Chris Ottolenghi, Erik Harms, Thorsten Marquardt   +2 more
exaly   +3 more sources

Challenges for cysteamine stabilization, quantification, and biological effects improvement

Journal of Pharmaceutical Analysis, 2020
The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of ...
Catherine Charcosset, Hélène Greige-Gerges   +1 more
exaly   +3 more sources

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum

EBioMedicine, 2015
Background: Cysteamine has recently been shown to have in vitro properties potentially therapeutically beneficial in cystic fibrosis (CF). In this study we investigated the antimicrobial and mucolytic activity of cysteamine against the complex biologic ...
Douglas Fraser-Pitt, Derry K Mercer
exaly   +3 more sources

Inhibition of Low-Density Lipoprotein Oxidation by Cysteamine, Cystamine, Cysteine and Cystine at Lysosomal pH and pH 7.4 [PDF]

Antioxidants
LDL can be oxidised in the lysosomes of macrophages. Cysteamine, a thiol antioxidant that accumulates in lysosomes, inhibits the oxidation of LDL by iron at lysosomal pH (pH 4.5) and protects against atherosclerosis in mice.
Emily J. Parkes, Ana M. Cruz, Amanpreet Kaur, Georgina R. Clark, Thomas E. Pulford, Christopher Ness, Feroz Ahmad, Yichuan Wen, David S. Leake   +8 more
doaj   +2 more sources

A Review on Biomedical, Biomolecular, and Environmental Monitoring Applications of Cysteamine Functionalized Nanomaterials [PDF]

Micromachines
Functionalizing agents enhance the photophysical properties of nanomaterials, thereby broadening their applications. Among these agents, cysteamine (SH-(CH2)2-NH2) is unique because of its free thiol (-SH) and amino (-NH2) groups.
Muthaiah Shellaiah
doaj   +2 more sources

Development of cysteamine loaded liposomes in liquid and dried forms for improvement of cysteamine stability

International Journal of Pharmaceutics, 2020
Despite the high aqueous solubility of cysteamine, its unpleasant organoleptic properties, hygroscopicity, instability in solutions, and poor pharmacokinetic profile are the main drawbacks that limit its use for medical and cosmetic purposes. In this study, cysteamine-loaded liposomes were prepared using the ethanol injection method.
Hélène Greige-Gerges, Catherine Charcosset   +1 more
exaly   +5 more sources

Cysteamine affects skeletal development and impairs motor behavior in zebrafish

Frontiers in Pharmacology, 2022
Cysteamine is a kind of feed additive commonly used in agricultural production. It is also the only targeted agent for the treatment of cystinosis, and there are some side effects in clinical applications. However, the potential skeletal toxicity remains
Chao Chen, Chao Chen, Yongliang Zheng, Yongliang Zheng, Xue Li, Xue Li, Li Zhang, Li Zhang, Kangyu Liu, Kangyu Liu, Sujie Sun, Sujie Sun, Zilin Zhong, Zilin Zhong, Hongmei Hu, Hongmei Hu, Fasheng Liu, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Yanlong Bi, Jianjun Chen, Jianjun Chen, Zigang Cao   +23 more
doaj   +1 more source

A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis

Orphanet Journal of Rare Diseases, 2021
Background Nephropathic cystinosis is a rare and severe metabolic disease leading to an accumulation of cystine in lysosomes which especially harms kidney function.
Christina van Stein, Sabrina Klank, Marianne Grüneberg, Chris Ottolenghi, Jürgen Grebe, Janine Reunert, Erik Harms, Thorsten Marquardt   +7 more
doaj   +1 more source

Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Cysteamine, an anti-oxidant aminothiol, is the treatment of choice for nephropathic cystinosis, a rare lysosomal storage disease. Cysteamine is a chemo-sensitization and radioprotection agent and its antitumor effects have been investigated ...
Toshio Fujisawa, Benjamin Rubin, Akiko Suzuki, Prabhudas S Patel, William A Gahl, Bharat H Joshi, Raj K Puri   +6 more
doaj   +1 more source