Results 51 to 60 of about 1,002,644 (386)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Nature Communications, 2017
Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet little is known about its biosynthesis and physiological functions.
T. Akaike, T. Ida, Fan-Yan Wei, M. Nishida, Y. Kumagai, M. Alam, H. Ihara, T. Sawa, Tetsuro Matsunaga, S. Kasamatsu, Akiyuki Nishimura, Masanobu Morita, K. Tomizawa, A. Nishimura, Satoshi Watanabe, K. Inaba, H. Shima, N. Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, M. Ohmuraya, P. Nagy, M. Feelisch, J. Fukuto, H. Motohashi   +25 more
semanticscholar   +1 more source

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +3 more sources

Transsulfuration pathway thiols and methylated arginines: the hunter community study [PDF]

, 2013
Background: Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase ...
Attia, John R., Carru, Ciriaco, Mangoni, Arduino A., McEvoy, Mark, Zinellu, Angelo   +4 more
core   +8 more sources

Optimizing Ergothioneine Biosynthesis and Antioxidant Activity in Agaricus spp. Through Amino Acid Supplementation and Yeast–Peptone Mixtures

Horticulturae
With increasing demand for antioxidant-rich foods, research has focused on cost-effective methods to produce natural antioxidants. Mushrooms, especially Agaricus species, are rich in bioactive compounds like ergothioneine, a potent antioxidant ...
Hojat Ghahremani-majd, Hasan Mumivand, Parisa Khanizadeh, Fatemeh Bakhshipoor, Sergio Argento   +4 more
doaj   +1 more source

Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6

Communications Biology, 2019
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic generation from sulfur-containing amino acids (SAAs) is well characterized. However, the existence of non-enzymatic H2S production from SAAs, the chemical mechanism, and
Jie Yang, P. Minkler, D. Grove, Rui Wang, B. Willard, R. Dweik, Christopher Hine   +6 more
semanticscholar   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Carrillo Gil, Laura, Diaz Rodriguez, Isabel, Herrero, Ignacio, Martinez Muñoz, Manuel, Sánchez-Monge Laguna de Rins, Rosa   +5 more
core   +2 more sources

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

Frontiers in Molecular Neuroscience, 2019
Huntington’s disease (HD) is a neurodegenerative disease triggered by expansion of polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and elicits toxicity by multiple mechanisms which range from dysregulated ...
Bindu D. Paul, Solomon H. Snyder, Solomon H. Snyder, Solomon H. Snyder   +3 more
doaj   +1 more source

Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study

Frontiers in Pharmacology, 2022
Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and a star medication used to treat non-small-cell lung carcinomas (NSCLCs).
Zheng Yuan, Xin Yu, Siyang Wu, Xiaonan Wu, Qiutao Wang, Wenhao Cheng, Weiyu Hu, Chen Kang, Wei Yang, Yingfei Li, Xiao-Yang Zhou   +10 more
doaj   +1 more source

Cysteine homeostasis.

, 2015
of essential biomolecules, such as vitamins, cofactors, antioxidants and many defence compounds, that are formed in response to adverse environmental conditions in which the sulfur moiety is the functional group. Sulfate is transported inside the plant, reduced to sulfide and incorporated into O-acetylserine (OAS) to form cysteine.
García, Irene, Romero, Luis C., Gotor, Cecilia   +2 more
openaire   +2 more sources

Cysteine proteases in atherosclerosis

The FEBS Journal, 2017
Atherosclerosis predisposes patients to cardiovascular diseases, such as myocardial infarction and stroke. Instigation of vascular injury is triggered by retention of lipids and inflammatory cells in the vascular endothelium. Whereas these vascular lesions develop in young adults and are mostly considered harmless, over time persistent inflammatory and
Tommy Weiss-Sadan, Israel Gotsman, Galia Blum   +2 more
openaire   +2 more sources