Results 61 to 70 of about 827,600 (338)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Precise Molecular Structures of Cysteine, Cystine, Hydrogen-Bonded Dicysteine, Cysteine Dipeptide, Glutathione and Acetyl Cysteine Based on Additivity of Atomic Radii [PDF]

, 2011
Structures of molecules are usually represented by arbitrary line drawings, ball and stick or space filling models. In recent years, the author found that using the appropriate radii of atoms and ions, bond lengths in inorganic, organic and biomolecules ...
Raji Heyrovska
core   +1 more source

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Gas-Phase Fragmentation Reactions of Protonated Cystine using High-Resolution Tandem Mass Spectrometry

Molecules, 2019
Cystine is an important biomolecule in living systems. Although collision-induced dissociation (CID)-based tandem mass spectrometry (MS/MS) is commonly applied for identification and quantification of cystine in both biomedical and nutritional studies ...
Pengwei Zhang, Wan Chan, Irene L. Ang, Rui Wei, Melody M. T. Lam, Kate M. K. Lei, Terence C. W. Poon   +6 more
doaj   +1 more source

Catch, Modify and Analyze: Methods of Chemoselective Modification of Cysteine-Containing Peptides

Molecules, 2022
One effective solution in the analysis of complex mixtures, including protein or cell hydrolysates, is based on chemoselective derivatization of a selected group of compounds by using selective tags to facilitate detection. Another method is based on the
Marta Kowalska, Remigiusz Bąchor
doaj   +1 more source

The nature of CuA in cytochrome c oxidase [PDF]

, 1982
The isolation and purification of yeast cytochrome c oxidase is described. Characterization of the purified protein indicates that it is spectroscopically identical with cytochrome c oxidase isolated from beef heart.
Brudvig, Gary W., Chan, Sunney I., Martin, Craig T., Scholes, Charles P., Stevens, Tom H., Wang, Hsin   +5 more
core  

Cysteine oxidation targets peroxiredoxins 1 and 2 for exosomal release through a novel mechanism of redox-dependent secretion [PDF]

, 2015
Non-classical protein secretion is of major importance as a number of cytokines and inflammatory mediators are secreted via this route. Current evidence indicates that there are several mechanistically distinct methods of non-classical secretion. We have
A Jackson, A Matte, A Rubartelli, A Rubartelli, C Mouta Carreira, Christopher Horst Lillig, E Schroder, E Schroder, E Venereau, EG Gerrits, Eva-Maria Hanschmann, F Tarantini, G Hoppe, GI Lancaster, H Shau, H Shau, I Prudovsky, IS Sloan, JR Riddell, JW Chang, JW Park, KE Szabo-Taylor, Leonore A. Herzenberg, Lisa Mullen, M Burke, M Derouazi, M Fratelli, M Schiraldi, M Tanudji, M Tanudji, ME Bianchi, MS Seo, Pietro Ghezzi, PK Anand, R Bertini, RR Razonable, S Carta, S Gardella, S Salzano, SA Gharib, SG Rhee, SK Mohan, SW Kang, T Shichita, TJ Tavender, TM LaVallee   +45 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Hydrogen Sulfide Signaling in Plants: Emerging Roles of Protein Persulfidation

Frontiers in Plant Science, 2018
Hydrogen sulfide (H2S) has been largely referred as a toxic gas and environmental hazard, but recent years, it has emerged as an important gas-signaling molecule with effects on multiple physiological processes in both animal and plant systems.
Angeles Aroca, Cecilia Gotor, Luis C. Romero   +2 more
doaj   +1 more source