Results 171 to 180 of about 120,191 (200)
The regulation of cysteine cathepsins and cystatins in human gliomas [PDF]
International Journal of Cancer, 2012 AbstractCysteine cathepsins play an important role in shaping the highly infiltrative growth pattern of human gliomas. We have previously demonstrated that the activity of cysteine cathepsins is elevated in invasive glioblastoma (GBM) cells in vitro, in part due to attenuation of their endogenous inhibitors, the cystatins.
Mara Popović +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Cysteine cathepsins and extracellular matrix degradation
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be among the major players in ECM degradation in vivo. During
Marko, Fonović, Boris, Turk
openaire +2 more sources
Fluorescent nitrile-based inhibitors of cysteine cathepsins
Bioorganic and Medicinal Chemistry Letters, 2012Cysteine cathepsins play an important role in many (patho)physiological conditions. Among them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides their role as drug targets, cysteine cathepsins are additionally considered to be possible biomarkers for inflammation and cancer.
Matthias D Mertens +2 more
exaly +3 more sources
Cysteine Cathepsins and the Skeleton
Clinical Reviews in Bone and Mineral Metabolism, 2011Cysteine cathepsins are lysosomal proteases with housekeeping as well as tissue-specific functions. One of their specialized functions includes the degradation of extracellular matrix proteins and the regulation of the immune response. In recent years, this protease family received increasing attention as drug targets for bone and cartilage-related ...
openaire +1 more source
Cysteine cathepsins: regulators of antitumour immune response
Expert Opinion on Biological Therapy, 2006Cysteine cathepsins are lysosomal cysteine proteases that are involved in a number of important biological processes, including intracellular protein turnover, propeptide and hormone processing, apoptosis, bone remodelling and reproduction. In cancer, the cathepsins have been linked to extracellular matrix remodelling and to the promotion of tumour ...
Natasa, Obermajer +2 more
openaire +2 more sources
Cysteine cathepsin proteases as pharmacological targets in cancer
Trends in Pharmacological Sciences, 2008Proteolytic activity is required for several key pro-tumorigenic processes: angiogenesis, invasion and metastasis. Consequently, increases in protease expression and activity are frequently reported in human cancers, and correlate with malignant progression and poor patient prognosis.
Carmela, Palermo, Johanna A, Joyce
openaire +2 more sources
Cathepsin K: a unique collagenolytic cysteine peptidase
bchm, 2013Abstract Cathepsin K has emerged as a promising target for the treatment of osteoporosis in recent years. Initially identified as a papain-like cysteine peptidase expressed in high levels in osteoclasts, the important role of this enzyme in bone metabolism was highlighted by the finding that mutations in the CTSK gene cause the rare ...
Marko, Novinec, Brigita, Lenarčič
openaire +2 more sources
The importance of cysteine cathepsin proteases for placental development
Journal of Molecular Medicine, 2006The typically lysosomal family of cysteine cathepsin proteases has been implicated in the development of the placenta in particular, from studies in the mouse. Here, we analysed overall expression, regulation and presence of transcript isoforms of cysteine cathepsins during human extra-embryonic development. All 11 family members are expressed in human
Varanou, Aikaterini +5 more
openaire +3 more sources
Lysosomal cysteine cathepsins: signaling pathways in apoptosis
bchm, 2007Abstract Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent data suggest that lysosomes and the endoplasmic reticulum also play important roles in the ...
Veronika, Stoka, Vito, Turk, Boris, Turk
openaire +2 more sources
[Cathepsin cysteine proteinases in the lung].
Pneumologie (Stuttgart, Germany), 1999Proteolytic enzymes play an important role during remodeling and digestion of extracellular matrix proteins. An overproduction of extracellular matrix or insufficient extracellular matrix digestion may result in fibrosis. Enhanced proteolytic activity or an insufficient inhibitory potential could be followed by emphysema development.
F, Bühling +3 more
openaire +1 more source