Results 151 to 160 of about 10,373 (179)

Cysteine cathepsins as therapeutic targets in inflammatory diseases

Expert Opinion on Therapeutic Targets, 2020
Introduction: Cysteine cathepsins are involved in the development and progression of numerous inflammation-associated diseases such as cancer, arthritis, bone and immune disorders. Consequently, there is a drive to progress research efforts focused on cathepsin use in diagnostics and as therapeutic targets in disease.Areas covered: This review ...
Matej Vizovisek, Georgy Mikhaylov, Boris Türk   +2 more
exaly   +4 more sources

Cysteine cathepsins and caspases in silicosis

Biological Chemistry, 2006
AbstractSilicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica. It leads to the formation of fibrohyalin nodes that result in progressive fibrosis. Alternatively, emphysema may occur, with abnormal destruction of collagen fibres in the advanced stages.
Gilles, Lalmanach, Elisabeth, Diot, Emmanuel, Godat, Fabien, Lecaille, Virginie, Hervé-Grépinet   +4 more
openaire   +2 more sources

Cysteine cathepsins in the immune response

Tissue Antigens, 2006
AbstractAntigen (Ag) processing by major histocompatibility complex class II (MHC) class II molecules is tightly linked with the proteases of the endosomal/lysosomal system. Cysteine (Cys) cathepsins, which constitute a major portion of this proteolytic system, have been found to have essential roles in both Ag processing and maturation of the MHC ...
T, Zavasnik-Bergant, B, Turk
openaire   +2 more sources

Cysteine Cathepsins in Neurological Disorders

Molecular Neurobiology, 2013
Increased proteolytic activity is a hallmark of several pathological processes, including neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine proteases, during degeneration of the central nervous system is frequently reported.
Anja, Pišlar, Janko, Kos
openaire   +2 more sources

The Future of Cysteine Cathepsins in Disease Management

Trends in Pharmacological Sciences, 2017
Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins have been investigated by pharmaceutical companies as drug targets. The first clinical results from targeting cathepsins by activity-based probes and substrates are paving the way for the next generation of molecular diagnostic imaging, whereas the majority of ...
Lovro, Kramer, Dušan, Turk, Boris, Turk
openaire   +2 more sources

The regulation of cysteine cathepsins and cystatins in human gliomas [PDF]

International Journal of Cancer, 2012
AbstractCysteine cathepsins play an important role in shaping the highly infiltrative growth pattern of human gliomas. We have previously demonstrated that the activity of cysteine cathepsins is elevated in invasive glioblastoma (GBM) cells in vitro, in part due to attenuation of their endogenous inhibitors, the cystatins.
Boris Gole, Peter C Huszthy, Mara Popovic   +2 more
exaly   +3 more sources

Cathepsin cysteine proteases in cardiovascular disease

The FASEB Journal, 2007
ABSTRACT Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM remodeling and have been implicated in the development and progression of cardiovascular diseases.
Suzanne P M, Lutgens, Kitty B J M, Cleutjens, Mat J A P, Daemen, Sylvia, Heeneman   +3 more
openaire   +2 more sources

Cysteine cathepsins and extracellular matrix degradation

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be among the major players in ECM degradation in vivo. During
Marko, Fonović, Boris, Turk
openaire   +2 more sources

Fluorescent nitrile-based inhibitors of cysteine cathepsins

Bioorganic and Medicinal Chemistry Letters, 2012
Cysteine cathepsins play an important role in many (patho)physiological conditions. Among them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides their role as drug targets, cysteine cathepsins are additionally considered to be possible biomarkers for inflammation and cancer.
Maxim Frizler, Matthias D Mertens, Michael Gutschow   +2 more
exaly   +3 more sources

Cysteine Cathepsins in Human Dentin-Pulp Complex

Journal of Endodontics, 2010
Collagen-degrading matrix metalloproteinases (MMPs) are expressed by odontoblasts and present in dentin. We hypothesized that odontoblasts express other collagen-degrading enzymes such as cysteine cathepsins, and their activity would be present in dentin, because odontoblasts are known to express at least cathepsin D.
Ivarne L, Tersariol, Saulo, Geraldeli, Christiane L, Minciotti, Fábio D, Nascimento, Virve, Pääkkönen, Marília T, Martins, Marcela R, Carrilho, David H, Pashley, Franklin R, Tay, Tuula, Salo, Leo, Tjäderhane   +10 more
openaire   +2 more sources