Results 161 to 170 of about 120,191 (200)
Cathepsin L as a Driver of Tumour Invasion and a Novel Therapeutic Target in Ovarian Cancer. [PDF]
Cancers (Basel)Elshahri I +6 more
europepmc +1 more source
Targeting Cathepsin C in Cancer Metastasis: Protease Network Activation, Inflammatory Crosstalk, and Therapeutic Opportunities. [PDF]
Int J Mol SciLiu Y, Hao L, Zheng L.
europepmc +1 more source
Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins
Journal of Dental Research, 2012 The co-expression of MMPs and cysteine cathepsins in the human dentin-pulp complex indicates that both classes of enzymes can contribute to the endogenous proteolytic activity of dentin. Chlorhexidine (CHX) is an efficient inhibitor of MMP activity. This
Fabio Dupart Nascimento +2 more
exaly +8 more sources
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Cysteine cathepsins in human cancer
Biological Chemistry, 2004AbstractProteases play causal roles in the malignant progression of human tumors. This review centers on the roles in this process of cysteine cathepsins, i.e., peptidases belonging to the papain family (C1) of the CA clan of cysteine proteases. Cysteine cathepsins, most likely along with matrix metalloproteases (MMPs) and serine proteases, degrade the
Bonnie F Sloane
exaly +3 more sources
Cysteine cathepsins and caspases in silicosis
Biological Chemistry, 2006AbstractSilicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica. It leads to the formation of fibrohyalin nodes that result in progressive fibrosis. Alternatively, emphysema may occur, with abnormal destruction of collagen fibres in the advanced stages.
Gilles, Lalmanach +4 more
openaire +2 more sources
Cysteine cathepsins in the immune response
Tissue Antigens, 2006AbstractAntigen (Ag) processing by major histocompatibility complex class II (MHC) class II molecules is tightly linked with the proteases of the endosomal/lysosomal system. Cysteine (Cys) cathepsins, which constitute a major portion of this proteolytic system, have been found to have essential roles in both Ag processing and maturation of the MHC ...
T, Zavasnik-Bergant, B, Turk
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Cysteine Cathepsins in Neurological Disorders
Molecular Neurobiology, 2013Increased proteolytic activity is a hallmark of several pathological processes, including neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine proteases, during degeneration of the central nervous system is frequently reported.
Anja, Pišlar, Janko, Kos
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Cysteine cathepsins: Cellular roadmap to different functions
Biochimie, 2008Cysteine cathepsins belong to the papain-like family C1 of clan CA cysteine peptidases. These enzymes are ubiquitously expressed and exert their proteolytic activity mainly, but not exclusively within the compartments along the endocytic pathway. Moreover, cysteine cathepsins are active in pericellular environments as soluble enzymes or bound to cell ...
Klaudia Brix, Silvia Jordans
exaly +3 more sources
Cathepsin cysteine proteases in cardiovascular disease
The FASEB Journal, 2007ABSTRACT Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM remodeling and have been implicated in the development and progression of cardiovascular diseases.
Suzanne P M, Lutgens +3 more
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The Future of Cysteine Cathepsins in Disease Management
Trends in Pharmacological Sciences, 2017Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins have been investigated by pharmaceutical companies as drug targets. The first clinical results from targeting cathepsins by activity-based probes and substrates are paving the way for the next generation of molecular diagnostic imaging, whereas the majority of ...
Lovro, Kramer, Dušan, Turk, Boris, Turk
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