Results 161 to 170 of about 10,373 (179)
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Cysteine Cathepsins and the Skeleton
Clinical Reviews in Bone and Mineral Metabolism, 2011Cysteine cathepsins are lysosomal proteases with housekeeping as well as tissue-specific functions. One of their specialized functions includes the degradation of extracellular matrix proteins and the regulation of the immune response. In recent years, this protease family received increasing attention as drug targets for bone and cartilage-related ...
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Cysteine cathepsins: regulators of antitumour immune response
Expert Opinion on Biological Therapy, 2006Cysteine cathepsins are lysosomal cysteine proteases that are involved in a number of important biological processes, including intracellular protein turnover, propeptide and hormone processing, apoptosis, bone remodelling and reproduction. In cancer, the cathepsins have been linked to extracellular matrix remodelling and to the promotion of tumour ...
Natasa, Obermajer +2 more
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Cathepsin K: a unique collagenolytic cysteine peptidase
bchm, 2013Abstract Cathepsin K has emerged as a promising target for the treatment of osteoporosis in recent years. Initially identified as a papain-like cysteine peptidase expressed in high levels in osteoclasts, the important role of this enzyme in bone metabolism was highlighted by the finding that mutations in the CTSK gene cause the rare ...
Marko, Novinec, Brigita, Lenarčič
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The importance of cysteine cathepsin proteases for placental development
Journal of Molecular Medicine, 2006The typically lysosomal family of cysteine cathepsin proteases has been implicated in the development of the placenta in particular, from studies in the mouse. Here, we analysed overall expression, regulation and presence of transcript isoforms of cysteine cathepsins during human extra-embryonic development. All 11 family members are expressed in human
Varanou, Aikaterini +5 more
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Cysteine cathepsin proteases as pharmacological targets in cancer
Trends in Pharmacological Sciences, 2008Proteolytic activity is required for several key pro-tumorigenic processes: angiogenesis, invasion and metastasis. Consequently, increases in protease expression and activity are frequently reported in human cancers, and correlate with malignant progression and poor patient prognosis.
Carmela, Palermo, Johanna A, Joyce
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Lysosomal cysteine cathepsins: signaling pathways in apoptosis
bchm, 2007Abstract Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent data suggest that lysosomes and the endoplasmic reticulum also play important roles in the ...
Veronika, Stoka, Vito, Turk, Boris, Turk
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Prodrug-Inspired Probes Selective to Cathepsin B over Other Cysteine Cathepsins
Journal of Medicinal Chemistry, 2014Cathepsin B (CTB) is a cysteine protease believed to be an important therapeutic target or biomarker for several diseases including aggressive cancer, arthritis, and parasitic infections. The development of probes capable of assessing CTB activity in cell lysates, living cells, and animal models of disease are needed to understand its role in disease ...
Morshed A, Chowdhury +6 more
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[Cathepsin cysteine proteinases in the lung].
Pneumologie (Stuttgart, Germany), 1999Proteolytic enzymes play an important role during remodeling and digestion of extracellular matrix proteins. An overproduction of extracellular matrix or insufficient extracellular matrix digestion may result in fibrosis. Enhanced proteolytic activity or an insufficient inhibitory potential could be followed by emphysema development.
F, Bühling +3 more
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Prognostic Impact of Cysteine Proteases Cathepsin B and Cathepsin L in Pancreatic Adenocarcinoma
Pancreas, 2004The cysteine proteases cathepsin B (CTSB) and L (CTSL) have been implicated in tumor spread and metastatic formation. In pancreatic adenocarcinoma, the role of these proteases is not very well defined. To find out which cell types produce CTSB and CTSL and to evaluate the prognostic impact of these proteases, 70 specimens from curatively resected ...
Marco, Niedergethmann +5 more
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Chemiluminescent probes for imaging cysteine cathepsin activity
Bioorganic & Medicinal Chemistry LettersThe cysteine cathepsins are a family of proteases that are widely expressed in diverse cell types. However, because their activity is highly upregulated at sites of inflammation, they are ideal targets for imaging a range of disease pathologies including cancer, atherosclerosis, fibrosis and others.
Jiyun, Zhu +6 more
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