Results 231 to 240 of about 20,394 (270)

Cysteine cathepsins as therapeutic targets in inflammatory diseases

Expert Opinion on Therapeutic Targets, 2020
Introduction: Cysteine cathepsins are involved in the development and progression of numerous inflammation-associated diseases such as cancer, arthritis, bone and immune disorders. Consequently, there is a drive to progress research efforts focused on cathepsin use in diagnostics and as therapeutic targets in disease.Areas covered: This review ...
Matej, Vizovišek, Eva, Vidak, Urban, Javoršek, Georgy, Mikhaylov, Andreja, Bratovš, Boris, Turk   +5 more
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The Future of Cysteine Cathepsins in Disease Management

Trends in Pharmacological Sciences, 2017
Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins have been investigated by pharmaceutical companies as drug targets. The first clinical results from targeting cathepsins by activity-based probes and substrates are paving the way for the next generation of molecular diagnostic imaging, whereas the majority of ...
Lovro, Kramer, Dušan, Turk, Boris, Turk
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Cathepsin cysteine proteases in cardiovascular disease

The FASEB Journal, 2007
ABSTRACT Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM remodeling and have been implicated in the development and progression of cardiovascular diseases.
Suzanne P M, Lutgens, Kitty B J M, Cleutjens, Mat J A P, Daemen, Sylvia, Heeneman   +3 more
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Cysteine Cathepsins in Neurological Disorders

Molecular Neurobiology, 2013
Increased proteolytic activity is a hallmark of several pathological processes, including neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine proteases, during degeneration of the central nervous system is frequently reported.
Anja, Pišlar, Janko, Kos
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Cysteine cathepsins and caspases in silicosis

Biological Chemistry, 2006
AbstractSilicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica. It leads to the formation of fibrohyalin nodes that result in progressive fibrosis. Alternatively, emphysema may occur, with abnormal destruction of collagen fibres in the advanced stages.
Gilles, Lalmanach, Elisabeth, Diot, Emmanuel, Godat, Fabien, Lecaille, Virginie, Hervé-Grépinet   +4 more
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Cysteine cathepsins and extracellular matrix degradation

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be among the major players in ECM degradation in vivo. During
Marko, Fonović, Boris, Turk
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Cysteine cathepsins in the immune response

Tissue Antigens, 2006
AbstractAntigen (Ag) processing by major histocompatibility complex class II (MHC) class II molecules is tightly linked with the proteases of the endosomal/lysosomal system. Cysteine (Cys) cathepsins, which constitute a major portion of this proteolytic system, have been found to have essential roles in both Ag processing and maturation of the MHC ...
T, Zavasnik-Bergant, B, Turk
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Cysteine Cathepsins in Human Dentin-Pulp Complex

Journal of Endodontics, 2010
Collagen-degrading matrix metalloproteinases (MMPs) are expressed by odontoblasts and present in dentin. We hypothesized that odontoblasts express other collagen-degrading enzymes such as cysteine cathepsins, and their activity would be present in dentin, because odontoblasts are known to express at least cathepsin D.
Ivarne L, Tersariol, Saulo, Geraldeli, Christiane L, Minciotti, Fábio D, Nascimento, Virve, Pääkkönen, Marília T, Martins, Marcela R, Carrilho, David H, Pashley, Franklin R, Tay, Tuula, Salo, Leo, Tjäderhane   +10 more
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Cathepsin D inactivates cysteine proteinase inhibitors cystatins

Biochemical and Biophysical Research Communications, 1988
The formation of inactive complexes in excess molar amounts of human cathepsins H and L with their protein inhibitors human stefin A, human stefin B and chicken cystatin at pH 5.6 has been shown by measurement of enzyme activity coupled with reverse-phase HPLC not to involve covalent cleavage of the inhibitors.
B, Lenarcic, J, Kos, I, Dolenc, P, Lucovnik, I, Krizaj, V, Turk   +5 more
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Cysteine cathepsins: regulators of antitumour immune response

Expert Opinion on Biological Therapy, 2006
Cysteine cathepsins are lysosomal cysteine proteases that are involved in a number of important biological processes, including intracellular protein turnover, propeptide and hormone processing, apoptosis, bone remodelling and reproduction. In cancer, the cathepsins have been linked to extracellular matrix remodelling and to the promotion of tumour ...
Natasa, Obermajer, Bojan, Doljak, Janko, Kos   +2 more
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