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[Cathepsin cysteine proteinases in the lung].
Pneumologie (Stuttgart, Germany), 1999Proteolytic enzymes play an important role during remodeling and digestion of extracellular matrix proteins. An overproduction of extracellular matrix or insufficient extracellular matrix digestion may result in fibrosis. Enhanced proteolytic activity or an insufficient inhibitory potential could be followed by emphysema development.
F, Bühling +3 more
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Cysteine cathepsins: multifunctional enzymes in cancer.
Nature reviews. Cancer, 2006Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the ...
Mona Mostafa, Mohamed, Bonnie F, Sloane
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Selective Activity‐Based Probes for Cysteine Cathepsins
Angewandte Chemie International Edition, 2007Anja, Watzke +7 more
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Cysteine cathepsins: A long and winding road towards clinics
Molecular Aspects of Medicine, 2022Eva Vidak, Boris Turk
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Cysteine cathepsins: Their biological and molecular significance in cancer stem cells
Seminars in Cancer Biology, 2018Anja Pišlar, Anahid Jewett, Janko Kos
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Role for Cysteine Protease Cathepsins in Heart Disease
Circulation, 2012Xian Wu Cheng,, Faha +2 more
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Selektive aktivitätsbasierte Sonden für Cystein‐Cathepsine
Angewandte Chemie, 2007Anja Watzke +7 more
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Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond
Matrix Biology, 2019Matej Vizovisek +2 more
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Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Nature Reviews Cancer, 2015Johanna A Joyce
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