Results 121 to 130 of about 13,297 (156)
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Toward Computer-Based Cleavage Site Prediction of Cysteine Endopeptidases
Biological Chemistry, 2003Identification of relevant substrates is essential for elucidation of in vivo functions of peptidases. The recent availability of the complete genome sequences of many eukaryotic organisms holds the promise of identifying specific peptidase substrates by systematic proteome analyses in combination with computer-based screening of genome databases ...
Lohmüller, T. +6 more
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Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation [PDF]
Biochemical Journal, 1992 The peptidyl diazomethane inactivator of cysteine endopeptidases, benzyloxycarbonyl-Tyr-Ala-CHN2, was tested as an inhibitor of interleukin 1 alpha-stimulated release of proteoglycan from bovine nasal septum cartilage explants. Like the previously tested epoxidyl peptide proinhibitor trans-epoxysuccinyl-leucylamido-(3-methyl)butane ethyl ester, it ...
D J Buttle, J Saklatvala
exaly +3 more sources
Comparison of Two Cysteine Endopeptidases from Pseudananas macrodontes (Morr.) Harms (Bromeliaceae)
Biological Chemistry, 2001The properties of two cysteine peptidases (macrodontain I and II) isolated from fruits of Pseudananas macrodontes have been compared. The enzymes showed optimum pH ranges near neutrality and were inhibited by E-64 and other cysteine peptidase inhibitors.
Laura M I López +2 more
exaly +3 more sources
A high-molecular-weight cysteine endopeptidase from rat skeletal muscle
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983A cytosolic enzyme of high molecular weight (about 500 000), which attacks native or denatured proteins (inter alia, casein, globin and hexokinase) was purified about 1000-fold from mixed rat skeletal muscles, including muscles freed of mast cells by prior treatment of the animals with the degranulator, compound 48/80.
F, Ismail, W, Gevers
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Effects of mechanical wounding on Carica papaya cysteine endopeptidases accumulation and activity
International Journal of Biological Macromolecules, 2006The mechanical wounding impact on the Carica papaya latex protein pattern was investigated by analyzing three latexes. A first one commercially available, a second harvested from unripe but fully grown fruits, both obtained from regularly tapped fruits. A third one was collected from similar fruits but wounded for the first time.
Azarkan, Mohamed +3 more
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A cysteine endopeptidase from barley malt which degrades hordein
Phytochemistry, 1989Abstract A cysteine endopeptidase of M r 29 000 which we have named malt endopeptidase-1 (MEP-1) was purified to homogeneity from a four-day green malt of barley ( Hordeum vulgare cv Schooner). It consists of two main species of pl 4.2 and 4.3 has a pH optimum of 4.5 for the hydrolysis of hordein and accounts for over a half of the hordein ...
Hilary A. Phillips, William Wallace
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Purification and partial characterization of a 31-kDa cysteine endopeptidase from germinated barley
Planta, 1996Proteolytic enzymes hydrolyze cereal seed storage proteins into small peptides and amino acids, which are very important for seed germination and the malting process. A cysteine-class endopeptidase was purified from 4-d-germinated barley (Hordeum vulgare L. cv. Morex).
N, Zhang, B L, Jones
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A RasMol study of the Mechanism of Inhibition of Cysteine Endopeptidase Enzyme Papain
Current Proteomics, 2009Cysteine endopeptidases regulate many physiological processes in the body and their impaired function may lead to several diseases. One of the methods of treating such diseases is achieved by controlling the proteolytic activity of these enzymes by using enzyme inhibition.
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1993
Cysteine endopeptidase inactivators were tested as inhibitors of interleukin 1-stimulated proteoglycan release from bovine nasal septum cartilage explants. Hydrophilic inactivators showed no inhibition at concentrations up to 100 microM. In contrast, lipophilic inactivators gave significant inhibition, which was both reversible and specific. No effects
D J, Buttle, J, Saklatvala, A J, Barrett
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Cysteine endopeptidase inactivators were tested as inhibitors of interleukin 1-stimulated proteoglycan release from bovine nasal septum cartilage explants. Hydrophilic inactivators showed no inhibition at concentrations up to 100 microM. In contrast, lipophilic inactivators gave significant inhibition, which was both reversible and specific. No effects
D J, Buttle, J, Saklatvala, A J, Barrett
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Histolysain and Other Entamoeba Cysteine Endopeptidases
2013Henning Scholze +2 more
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