Cysteine endopeptidases - Open Access .click

Cancer Biotherapy and Radiopharmaceuticals, 1996
Role of cysteine endopeptidases in cancerogenesis steps: neoplastic transformation, invasion and metastasis is reviewed and discussed. Positive correlation between tumor invasiveness, as well as its metastatic potential and secretion of cysteine endopeptidase (particularly cathepsins B and L) has been documented well in literature.
Maciej Siewiński
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Cysteine Endopeptidases and Their Inhibitors in Malignant Progression of Rat Embryo Fibroblasts

Biological Chemistry Hoppe-Seyler, 1992
Cathepsins B and L and their endogenous inhibitors were evaluated in rat embryo fibroblast lines which have been developed as a model system for the study of malignant progression and metastatic capability. Three groups of lines were analyzed: 1) immortalized/non-tumorigenic, 2) tumorigenic/metastatic lines transfected with c-Ha-ras, and 3) metastatic ...
Bonnie F Sloane, J Rozhin, Kamiar Moin
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Toward Computer-Based Cleavage Site Prediction of Cysteine Endopeptidases

Biological Chemistry, 2003
Identification of relevant substrates is essential for elucidation of in vivo functions of peptidases. The recent availability of the complete genome sequences of many eukaryotic organisms holds the promise of identifying specific peptidase substrates by systematic proteome analyses in combination with computer-based screening of genome databases ...
Thomas Reinheckel, Thomas Dandekar
exaly +4 more sources

animals
molecular sequence data
amino acid sequence

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cysteine proteinase inhibitors
substrate specificity
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