Results 41 to 50 of about 37,687 (302)

Role of Proteases in Chronic Obstructive Pulmonary Disease

Frontiers in Pharmacology, 2017
Chronic obstructive pulmonary disease (COPD) is generally associated with progressive destruction of airways and lung parenchyma. Various factors play an important role in the development and progression of COPD, like imbalance of proteases ...
Kailash C. Pandey, Sajal De, Pradyumna K. Mishra   +2 more
doaj   +1 more source

Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. [PDF]

PLoS Pathogens, 2009
Periodontitis is an inflammatory disease of the supporting structures of the teeth caused by, among other pathogens, Prevotella intermedia. Many strains of P.
Michal Potempa, Jan Potempa, Tomasz Kantyka, Ky-Anh Nguyen, Katarzyna Wawrzonek, Surya P Manandhar, Katarzyna Popadiak, Kristian Riesbeck, Sigrun Eick, Anna M Blom   +9 more
doaj   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Sánchez-Monge Laguna de Rins, Rosa, Diaz Rodriguez, Isabel, Herrero, Ignacio, Carrillo Gil, Laura, Martinez Muñoz, Manuel   +5 more
core   +1 more source

Transgenic potatoes for potato cyst nematode control can replace pesticide use without impact on soil quality. [PDF]

PLoS ONE, 2012
Current and future global crop yields depend upon soil quality to which soil organisms make an important contribution. The European Union seeks to protect European soils and their biodiversity for instance by amending its Directive on pesticide usage ...
Jayne Green, Dong Wang, Catherine J Lilley, Peter E Urwin, Howard J Atkinson   +4 more
doaj   +1 more source

Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with Remdesivir

Biomedicines, 2021
The coronavirus disease 2019 (COVID-19) pandemic severely impacts health, economy, and society worldwide. Antiviral drugs against SARS-CoV-2 are urgently needed to cope with this global crisis. It has been found that the biogenesis and release mechanisms
Supasek Kongsomros, Ampa Suksatu, Phongthon Kanjanasirirat, Suwimon Manopwisedjaroen, Somsak Prasongtanakij, Kedchin Jearawuttanakul, Suparerk Borwornpinyo, Suradej Hongeng, Arunee Thitithanyanont, Somchai Chutipongtanate   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cysteine proteinase inhibitors: purification and gene isolation [PDF]

, 1989
Genetic engineering has produced a transgenic insect- resistant plant which produces a serine protease inhibitor (Hilder et al., 1987). More insects can be targetted if a plant can be made to produce thiol protease inhibitors.
Fones, Angela Mei Ling
core  

Putrescine-dependent re-localization of TvCP39, a cysteine proteinase involved in Trichomonas vaginalis cytotoxicity. [PDF]

PLoS ONE, 2014
Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP) involved in the trichomonal cytotoxicity.
Bertha Isabel Carvajal-Gamez, Laura Itzel Quintas-Granados, Rossana Arroyo, Laura Isabel Vázquez-Carrillo, Lucero De los Angeles Ramón-Luing, Eduardo Carrillo-Tapia, María Elizbeth Alvarez-Sánchez   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source