Results 21 to 30 of about 778,605 (292)

Selective loss of cysteine residues and disulphide bonds in a potato proteinase inhibitor II family. [PDF]

PLoS ONE, 2011
Disulphide bonds between cysteine residues in proteins play a key role in protein folding, stability, and function. Loss of a disulphide bond is often associated with functional differentiation of the protein.
Xiu-Qing Li, Tieling Zhang, Danielle Donnelly   +2 more
doaj   +1 more source

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP], Oliva, Maria Luiza V. [UNIFESP], Maria Luiza V. Oliva, Mayer, Barbara, Neth, Peter, Andrade de Paula, Claudia Alessandra [UNIFESP], Sampaio, Misako U., Nakahata, Adriana Miti [UNIFESP], Christian Ries, Adriana Miti Nakahata, Andrade de Paula, Claudia Alessandra, Karow, Marisa, Barbara Mayer, Cláudia Alessandra Andrade de Paula, Marisa Karow, Marianne Jochum, Oliva, Maria Luiza V., Jochum, Marianne, Misako U. Sampaio, Ries, Christian, Nakahata, Adriana Miti, Peter Neth   +21 more
core   +1 more source

Expression of two barley proteinase inhibitors in tomato promotes endogenous defensive response and enhances resistance to Tuta absoluta

BMC Plant Biology, 2018
Background Plants and insects have coexisted for million years and evolved a set of interactions which affect both organisms at different levels. Plants have developed various morphological and biochemical adaptations to cope with herbivores attacks ...
Rim Hamza, Meritxell Pérez-Hedo, Alberto Urbaneja, José L. Rambla, Antonio Granell, Kamel Gaddour, José P. Beltrán, Luis A. Cañas   +7 more
doaj   +1 more source

The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]

Biochemical Journal, 1986
A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane ...
P, Rauber, H, Angliker, B, Walker, E, Shaw   +3 more
openaire   +2 more sources

Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity

Virology Journal, 2005
Through the use of transient expression assays and directed genetics, the vaccinia virus (VV) I7L gene product has been implicated as the major maturational proteinase required for viral core protein cleavage to occur during virion assembly.
Hruby Dennis E, Byrd Chelsea M
doaj   +1 more source

Identification and expression analysis of a novel phytocystatin in developing and germinating seeds of triticale (×Triticosecale Wittm.)

Acta Societatis Botanicorum Poloniae, 2015
In this paper the complete cDNA sequence of a newly identified triticale phytocystatin, TrcC-7, was analyzed. Because TrcC-7 transcripts were present in seeds, we hypothesized that it may regulate storage protein accumulation and degradation.
Joanna Simińska, Wiesław Bielawski
doaj   +1 more source

Cystatins from the Human Liver Fluke Opisthorchis viverrini: Molecular Characterization and Functional Analysis

Pathogens, 2023
A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc, Rudi Grams, Sinee Siricoon, Nanthawat Kosa, Dawid Krenc, Wansika Phadungsil, Pongsakorn Martviset   +6 more
doaj   +1 more source

Overexpression of a cysteine proteinase inhibitor gene from Jatropha curcas confers enhanced tolerance to salinity stress

Electronic Journal of Biotechnology, 2015
Background: Cysteine proteinase inhibitor (cystatin, CPI) is one of the most important molecules involved in plant development and defense, especially in the regulation of stress responses.
Rui Li, Wanjun Wang, Wenguo Wang, Fosheng Li, Qingwei Wang, Ying Xu, Shenghua Wang   +6 more
doaj   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Sánchez-Monge Laguna de Rins, Rosa, Diaz Rodriguez, Isabel, Herrero, Ignacio, Carrillo Gil, Laura, Martinez Muñoz, Manuel   +5 more
core   +1 more source

Membrane-Permeable Calpain Inhibitors Promote Rat Oral Mucosal Epithelial Cell Proliferation by Inhibiting IL-1α Signaling. [PDF]

PLoS ONE, 2015
To standardise regenerative medicine using cultured cells, the use of serum-free, chemically defined media will be necessary. We have reported that IL-1α inhibits the growth of epithelial cells in culture and that recombinant IL-1 receptor antagonist (IL-
Makoto Kondo, Masayuki Yamato, Ryo Takagi, Hideo Namiki, Teruo Okano   +4 more
doaj   +1 more source