Results 31 to 40 of about 778,605 (292)

The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein [PDF]

FEBS Letters, 1989
Peptide maps obtained by reversed‐phase HPLC of tryptic digests of isoelectric form 1 (pI=6.5) and 2 (pI=5.6) of chicken egg white cystatin revealed that the difference was located only in a single peptide (residues Ser‐74—Lys‐91). Ser‐80 of cystatin 2 was subsequently identified as being modified by phosphorylation.
Laber, Bernd, Krieglstein, Kerstin, Henschen, Agnes, Kos, Janko, Turk, Vito, Huber, Robert, Bode, Wolfram   +6 more
openaire   +2 more sources

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Liu J, Nie Z, Chen X, Ji G, Zhang Y, Zhao Z, Zhang Y, Du X, Zhou Z, Li J, Yang Y, Sun F, Yan Z, Lu H.   +13 more
europepmc   +2 more sources

Digestive proteolytic activity in the gut and salivary glands of the predatory bug Podisus maculiventris (Heteroptera: Pentatomidae); effect of proteinase inhibitors

European Journal of Entomology, 2005
Proteinase activity in the midgut of the pentatomid stinkbug Podisus maculiventris was investigated. The optimal pH for adult and nymph proteolysis was pH 6.0 and pH 6.5, respectively.
Howard A. BELL, Rachel E. DOWN, John P. EDWARDS, John A. GATEHOUSE, Angharad M.R. GATEHOUSE   +4 more
doaj   +1 more source

An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches. [PDF]

PLoS ONE, 2018
Phoneutria nigriventer is one of the largest existing true spiders and one of the few considered medically relevant. Its venom contains several neurotoxic peptides that act on different ion channels and chemical receptors of vertebrates and invertebrates.
Marcelo R V Diniz, Ana L B Paiva, Clara Guerra-Duarte, Milton Y Nishiyama, Mauricio A Mudadu, Ursula de Oliveira, Márcia H Borges, John R Yates, Inácio de L Junqueira-de-Azevedo   +8 more
doaj   +1 more source

The cystatins: Protein inhibitors of cysteine proteinases

FEBS Letters, 1991
The last decade has witnessed enormous progress of protein inhibitors of cysteine proteinases concerning their structures, functions and evolutionary relationships. Although they differ in their molecular properties and biological distribution, they are structurally related proteins.
Turk, Vito, Bode, Wolfram
openaire   +2 more sources

The tick-derived anticoagulant madanin is processed by thrombin and factor Xa. [PDF]

PLoS ONE, 2013
The cysteine-less peptidic anticoagulants madanin-1 and madanin-2 from the bush tick Haemaphysalis longicornis are the founding members of the MEROPS inhibitor family I53.
Ana C Figueiredo, Daniele de Sanctis, Pedro José Barbosa Pereira   +2 more
doaj   +1 more source

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1 [PDF]

, 2005
Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1.
Listwan, P., Flanagan, Jack U., Flanagan, JU, Martin, Jennifer L, Listwan, P, Wells, Christine A, Kobe, Bostjan, Hume, DA, Cowieson, Nathan, Martin, Jennifer L., Hume, D A, Ravasi, T., Listwan, Pawel, Kellie, S, Kobe, B., Martin, Jennifer Louise, Cowieson, N. P., Martin, J. L., Huber, T, Huber, Thomas, Aagaard, A, Kobe, B, Flanagan, J. U., Ravasi, Timothy, Aagaard, A., A. Wells, Christine, Wells, C. A., Wells, Christine A., Aagaard, Anna, Wells, Christine, Flanagan, Jack U, Cowieson, N, Kellie, S., Huber, T. L., Hume, David A, Hume, D. A., Kellie, Stuart, Ravasi, T, Hume, David A., Wells, CA, Martin, JL   +40 more
core   +1 more source

Cysteine proteinases and cystatins

Brazilian Archives of Biology and Technology, 2003
This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests.
Adeliana S. Oliveira, José Xavier-Filho, Maurício P. Sales   +2 more
doaj   +1 more source

Gene variants of coagulation related proteins that interact with SARS-CoV-2.

PLoS Computational Biology, 2021
Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated with ...
David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Kyle Laurie, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A Komar, Michael DiCuccio, Chava Kimchi-Sarfaty   +9 more
doaj   +1 more source

Significance of Cuscutain, a cysteine protease from Cuscuta reflexa, in host-parasite interactions

BMC Plant Biology, 2010
Background Plant infestation with parasitic weeds like Cuscuta reflexa induces morphological as well as biochemical changes in the host and the parasite. These modifications could be caused by a change in protein or gene activity.
Fuchsbauer Hans-Lothar, Albert Markus, Bleischwitz Marc, Kaldenhoff Ralf   +3 more
doaj   +1 more source