Results 171 to 180 of about 108,777 (376)

Recombinant DNA-derived forms of human alpha 1-proteinase inhibitor. Studies on the alanine 358 and cysteine 358 substituted mutants.

, 1986
Nancy Matheson, H L Gibson, R A Hallewell, P J Barr, James Travis   +4 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Cathepsin B - indicator for the release of lysosomal cyasteine proteinases in severe trauma and inflammation [PDF]

, 1990
Assfalg-Machleidt, Irmgard, Billing, Arend, Jochum, Marianne, Joka, Theo, Machleidt, Werner, Nast-Kolb, Dieter, Rothe, Gregor, Scheuber, Heinz- Peter, Siebeck, Matthias, Valet, Günter, Zauner, Rita   +10 more
core   +1 more source

Cloning and sequencing of cDNA encoding a rat salivary cysteine proteinase inhibitor inducible by beta-adrenergic agonists.

, 1988
Phyllis A. Shaw, Jafna L. Cox, Tibor Barka, Y Naito   +3 more
openalex   +1 more source

Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases [PDF]

, 2001
Yuan‐Ping Pang, Kun Xu, Thomas M. Kollmeyer, Emanuele Perola, William J. McGrath, Dave T. Green, Walter F. Mangel   +6 more
openalex   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Purification and Characterization of a Cysteine Proteinase Inhibitor(Cystatin) from Seeds of Foxtail Millet, Setaria italica.

, 2000
Misao Tashiro, Akie Kurata, Atsuko Hasegawa, Sayuri Sawada   +3 more
openalex   +2 more sources

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis [PDF]

, 2004
Primož Strojan, Irena Oblak, Branka Svetic, Lojze Šmid, Janko Kos   +4 more
openalex   +1 more source

Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.

Arthritis & Rheumatism, 1994
R. Esser, R. Angelo, M. Murphey, L. Watts, L. Thornburg, J. Palmer, J. Talhouk, R. Smith   +7 more
semanticscholar   +1 more source