Results 181 to 190 of about 108,777 (376)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Partial characterization of a cysteine protease inhibitor of Plasmodium vivax. [PDF]

Parasites Hosts Dis
Võ TC, Kang JM, Lê HG, Na BK.
europepmc   +1 more source

Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites.

Blood, 1996
N. Gamboa de Domínguez, P. Rosenthal
semanticscholar   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Comprehensive Analysis of Cathepsin Genes in Hemiptera: Functional Characterization of the Venomous Cathepsin B from <i>Sycanus bifidus</i>. [PDF]

Insects
Liang W, Liu S, Wang Y, Wu C, Wang W, Zhu J.   +5 more
europepmc   +1 more source

Rat alpha 1-cysteine proteinase inhibitor. An acute phase reactant identical with alpha 1 acute phase globulin.

, 1983
Frédéric Esnard, F. Gauthier
openalex   +1 more source

Molecular Cloning and Functional Expression of cDNA Encoding the Cysteine Proteinase Inhibitor Sca from Sunflower Seeds [PDF]

, 2001
Yoshiaki Kouzuma, Keiko TSUKIGATA, Hideko Inanaga, Keiko Doi-Kawano, Nobuyuki Yamasaki, Makoto Kimura   +5 more
openalex   +1 more source

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

Advanced Science, EarlyView.
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An, Xinyu Dong, Zhengbo Li, Shuangfeng Qin, Guangzhao Xu, Xiangguo Yue, Xudong Wang, Wen Sun, Zhe‐Sheng Chen, Weiguo Song, Liuya Wei, Fahui Li   +14 more
wiley   +1 more source

Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review. [PDF]

Clin Oral Investig
Pedrosa ME, Martin V, Fernandes MH, Gomes PS.   +3 more
europepmc   +1 more source

Elastase-alpha1-proteinase inhibitor complex [PDF]

, 1984
Bergmeyer, H. U., Bergmeyer, J., Graßl, M., Jochum, Marianne, Neumann, S.   +4 more
core   +1 more source