Results 71 to 80 of about 108,777 (376)

Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro. [PDF]

PLoS ONE, 2012
Poxviruses express highly active inhibitors, including serine proteinase inhibitors (serpins), designed to target host immune defense pathways. Recent work has demonstrated clinical efficacy for a secreted, myxomaviral serpin, Serp-1, which targets the ...
Kasinath Viswanathan, Ilze Bot, Liying Liu, Erbin Dai, Peter C Turner, Babajide Togonu-Bickersteth, Jakob Richardson, Jennifer A Davids, Jennifer M Williams, Mee Y Bartee, Hao Chen, Theo J C van Berkel, Erik A L Biessen, Richard W Moyer, Alexandra R Lucas   +14 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis

Arthritis Research & Therapy, 2023
Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs.
Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama, Minoru Hasegawa   +7 more
doaj   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Obtaining of transgenic papaya plants var. Maradol roja that carry out the rice oryzacystatin gene

Biotecnología Vegetal, 2004
Papaya (Carica papaya L.), is severely affected by Papaya Ringspot virus, which belongs to plant potyvirus group. A recent strategy for pest control produced by this virus is the transformation with genes encoding cysteine proteinase inhibitors.
Milady F. Mendoza, Ana Luisa Darias, Maylín Cruz, Jorge Gallardo, Marisol Tejeda, Rafael Gómez, Orelvis Portal   +6 more
doaj  

Cystatin C: Its role in pathogenesis of OSMF

Journal of Oral Biology and Craniofacial Research, 2014
Oral Submucous Fibrosis (OSF) is a chronic disorder characterized by fibrosis of the mucosa lining the upper digestive tract involving the oral cavity, oro- and hypopharynx and the upper third of the oesophagus.
P.C. Anila Namboodiripad
doaj   +1 more source

The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi [PDF]

, 2006
Papain-like cysteine proteases are important for the survival of the flagellated protozoa Trypanosoma cruzi, the causative agent of Chagas' Disease.
Judice, Wagner AS, Juliano, Luiz, Juliano, Maria Aparecida, Lima, Ana Paula CD, Reis, Flavia Coelho Garcia dos, Scharfstein, Julio   +5 more
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Preliminary analysis of the proteolytic enzymes in the excretory-secretory products of the adult stages of the dog hookworm Uncinaria stenocephala

Parasite, 2001
The paper describes an introductory characterisation of proteinases present in the excretory-secretory products (ESP) of adult Uncinaria stenocephala.
Kotomski G., Wedrychowicz H.
doaj   +1 more source

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. [PDF]

PLoS Pathogens, 2016
Dengue is the most prevalent arboviral disease in humans and a major public health problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially fatal complications, is a critical determinant of dengue severity.
Henry Puerta-Guardo, Dustin R Glasner, Eva Harris   +2 more
doaj   +1 more source