Results 1 to 10 of about 95,243 (337)

Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths [PDF]

Journal of Veterinary Internal Medicine
Background The majority of cystine uroliths occur in intact male dogs. Androgen‐dependent (Type III) cystinuria is considered the most common cause. Objectives Identify dog breeds in which castration is likely to decrease the risk of cystine uroliths ...
Jody P. Lulich, Rachael Ulrich, Eva Furrow   +2 more
doaj   +2 more sources

Outcomes of Tiopronin and D-Penicillamine Therapy in Pediatric Cystinuria: A Clinical Comparison of Two Cases [PDF]

Reports
Background and Clinical Significance: Cystinuria is the most common genetic cause of pediatric nephrolithiasis, characterized by impaired renal cystine reabsorption and resulting in increased urinary cystine excretion.
Brooke Schaefer, Adinoyi Garba, Xiaoyan Wu   +2 more
doaj   +2 more sources

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition [PDF]

Advanced Science
Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD‐1/PD‐L1 inhibitors is only 20%‐30%. Thus, more effective combination therapies are needed.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Andreas Lundqvist, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
doaj   +2 more sources

Local Guidance on the Management of Nephropathic Cystinosis in the Gulf Cooperation Council (GCC) Region [PDF]

Children
Cystinosis is a rare systemic disease characterized by the accumulation of cystine in tissues, leading to multi-organ damage. Infantile nephropathic cystinosis is the dominant and severe form of cystinosis with critical renal manifestations that require ...
Hassan Aleid, Turki AlShareef, Ahmad Kaddourah, Maryam Zeinelabdin, Mohamad M. Alkadi, Badria Al Ghaithi, Yasser Abdelkawy, Eihab Al Khasawneh, Elena Levtchenko, Khalid Alhasan   +9 more
doaj   +2 more sources

Role of Dual Energy CT Scan in Evaluation of the Chemical Composition of Renal Stones [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: For appropriate management of renal stone knowing its composition is important. Laboratory chemical analysis of the stones involves sophisticated techniques.
Sachin Khanduri, Umar Faizan Sagar, Nazia Khan, Nitin Chahar, Shreshtha Jain, Farzan Khan, Anchal Singh, Neha Nagpal   +7 more
doaj   +1 more source

Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. [PDF]

PLoS ONE, 2015
Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC.
Iwao Ohtsu, Yusuke Kawano, Marina Suzuki, Susumu Morigasaki, Kyohei Saiki, Shunsuke Yamazaki, Gen Nonaka, Hiroshi Takagi   +7 more
doaj   +1 more source

Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006‐2018)

Journal of Veterinary Internal Medicine, 2021
Background Urolithiasis is a common and often recurrent problem in dogs. Objective To evaluate trends in urolith composition in dogs and to assess risk factors for urolithiasis, including age, breed, sex, neuter status, urolith location, and bacterial ...
Lucy Kopecny, Carrie A. Palm, Gilad Segev, Jodi L. Westropp   +3 more
doaj   +1 more source

Biomarkers in Nephropathic Cystinosis: Current and Future Perspectives

Cells, 2022
Early diagnosis and effective therapy are essential for improving the overall prognosis and quality of life of patients with nephropathic cystinosis. The severity of kidney dysfunction and the multi-organ involvement as a consequence of the increased ...
Francesco Emma, Giovanni Montini, Marco Pennesi, Licia Peruzzi, Enrico Verrina, Bianca Maria Goffredo, Fabrizio Canalini, David Cassiman, Silvia Rossi, Elena Levtchenko   +9 more
doaj   +1 more source

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

eLife, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms ...
Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning   +6 more
doaj   +1 more source

Production of recombinant human xCT (SLC7A11) and reconstitution in proteoliposomes for functional studies

Frontiers in Physiology, 2022
The plasma membrane transporter xCT belongs to the SLC7 family and has the physiological role of mediating the exchange of glutamate and cystine across the cell plasma membrane, being crucial for redox control.
Michele Galluccio, Mariafrancesca Scalise, Gilda Pappacoda, Martina Scarpelli, Marcella Bonanomi, Marcella Bonanomi, Daniela Gaglio, Daniela Gaglio, Cesare Indiveri, Cesare Indiveri   +9 more
doaj   +1 more source