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Intracellular Distribution of Cystine in Cystine-Loaded Proximal Tubules [PDF]
Cellular cystine loading with cystine dimethyl ester has been shown to inhibit transport in proximal convoluted tubules perfused in vitro and decrease the rate of oxygen consumption in suspensions of proximal tubules. The present study was designed to examine the intracellular distribution of cystine in this model of the Fanconi syndrome of cystinosis ...
Michel Baum+2 more
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DETOXICATION OF CYANIDE BY CYSTINE
SUMMARY Chemical studies on the nature of the reaction product between cystine and cyanide ion support formulation of the structure as 2-imino-4-thiazoli- dinecarboxylic acid. The compound was inert metabolically when fed to the rat or when injected. On treatment with acid, a small amount of thio- cyanate was produced.
Shirley Lucille Cooley, John L. Wood
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Crystallization of cystine [PDF]
Cystine is an amino acid, which is a constituent of the urinary stones. It also is deposited in eyes, thyroid glands, bone marrow and white blood corpuscles. Crystals of cystine have been grown by both solution and gel methods. Small bunched hexagonal crystals, along with many other morphological crystals of size 0.3 mm across, were obtained.
E.K. Girija+2 more
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Our understanding of the molecular basis of cystinuria has deepened as the result of the causative genes, SLC3A1 and SLC7A9, being identified. The proteins coded for by these genes form a heterodimer responsible for reabsorption of filtered cystine in the proximal tubule. Failure of this transport system to be targeted to the apical membrane, as in the
Fattah, Hasan+2 more
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Scaffolding of Cystine‐Stabilized Miniproteins
AbstractBiomolecular scaffolds were engineered by genetically fusing robust miniproteins in a sequence, like a chain. By fusing these miniprotein chains to a teal fluorescent protein (TFP), an efficient strategy was devised for their production in E. coli.
Arjan Barendregt+7 more
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Effect of cystine loading and cystine dimethylester on renal brushborder membrane transport
The effect of loading renal tubule cells with cystine was studied by incubating them with cystine dimethylester. Proline uptake into brushborder membrane vesicles isolated from the cystine loaded cells was not different from that observed into brushborder vesicles isolated from tubules incubated in buffer alone.
John W. Foreman, Linda L. Benson
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On the Determination and Preparation of Cystine [PDF]
T. Kobayashi, Y. Okuka
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