Cystinuria in an Australian Cattle Dog Family—A Seemingly Androgen-Associated Autosomal Dominant Trait [PDF]
Veterinary SciencesIn Australian Cattle Dogs (AUCDs), cystinuria was reported to be an autosomal dominant trait caused by a 6 bp deletion in the SLC3A1 gene (type II-A). Here we report an androgen association in this breed.
Alexandra Kehl +6 more
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Redox State of Glutathione and Cysteine in Plasma Following Acute Stroke [PDF]
AntioxidantsIschemic stroke is a major cause of long-term disability and death, with oxidative stress contributing substantially to post-ischemic injury. Reperfusion restores oxygen supply but simultaneously increases reactive oxygen species (ROS), amplifying ...
Christopher McGinley +4 more
doaj +2 more sources
Role of Dual Energy CT Scan in Evaluation of the Chemical Composition of Renal Stones [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: For appropriate management of renal stone knowing its composition is important. Laboratory chemical analysis of the stones involves sophisticated techniques.
Sachin Khanduri +7 more
doaj +1 more source
Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. [PDF]
PLoS ONE, 2015 Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC.
Iwao Ohtsu +7 more
doaj +1 more source
Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006‐2018)
Journal of Veterinary Internal Medicine, 2021 Background Urolithiasis is a common and often recurrent problem in dogs. Objective To evaluate trends in urolith composition in dogs and to assess risk factors for urolithiasis, including age, breed, sex, neuter status, urolith location, and bacterial ...
Lucy Kopecny +3 more
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Biomarkers in Nephropathic Cystinosis: Current and Future Perspectives
Cells, 2022 Early diagnosis and effective therapy are essential for improving the overall prognosis and quality of life of patients with nephropathic cystinosis. The severity of kidney dysfunction and the multi-organ involvement as a consequence of the increased ...
Francesco Emma +9 more
doaj +1 more source
eLife, 2021 The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms ...
Margaret E Torrence +6 more
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj +1 more source
Frontiers in Physiology, 2022 The plasma membrane transporter xCT belongs to the SLC7 family and has the physiological role of mediating the exchange of glutamate and cystine across the cell plasma membrane, being crucial for redox control.
Michele Galluccio +9 more
doaj +1 more source
Genetic Landscape of Nephropathic Cystinosis in Russian Children
Frontiers in Genetics, 2022 Nephropathic cystinosis is a rare autosomal recessive disorder characterized by amino acid cystine accumulation and caused by biallelic mutations in the CTNS gene.
K. V. Savostyanov +12 more
doaj +1 more source