Results 1 to 10 of about 101,249 (389)
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein & Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Li Zhuang, Boyi Gan
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Molecular jamming - the cystine slipknot mechanical clamp in all-atom simulations [PDF]
, 2011 A recent survey of 17 134 proteins has identified a new class of proteins which are expected to yield stretching induced force-peaks in the range of 1 nN. Such high force peaks should be due to forcing of a slip-loop through a cystine ring, i.e. by generating a cystine slipknot. The survey has been performed in a simple coarse grained model.
Carrion-Vazquez M. +4 more
arxiv +3 more sources
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization [PDF]
bioRxiv, 2023 Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis.
Berquez, Marine +11 more
core +2 more sources
eLife, 2014 Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive ...
Scott J Dixon +10 more
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eLife, 2017 Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to ...
Alexander Muir +5 more
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Inducing disulfidptosis in tumors:potential pathways and significance [PDF]
MedCommRegulated cell death (RCD) is crucial for the elimination of abnormal cells. In recent years, strategies aimed at inducing RCD, particularly apoptosis, have become increasingly important in cancer therapy.
Tao Mi +4 more
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Redox Biology, 2020 Ferroptosis is a new form of regulated cell death driven by iron-dependent lipid peroxidation. Glutaminolysis and tricarboxylic acid cycle are involved in ferroptosis, but the underlying metabolic process remains unclear.
Daiha Shin +4 more
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Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report [PDF]
European Journal of Medical Research, 2012 Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder. In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of ...
Qiao Tie +6 more
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An Open-Label, Phase III Study to Assess the Efficacy and Safety of Cysteamine Ophthalmic Solution 0.55% in Japanese Cystinosis Patients [PDF]
Clinical OphthalmologyNobuhiro Goi,1 Fumino Iwata,2 Yoko Sugihara,3 Shingo Higa,1 Taiichiro Chikama4 1Medical Affairs, Viatris Pharmaceuticals Japan G.K., Tokyo, Japan; 2Iwata Eye Clinic, 2-15-21 Nishinakanobu, Shinagawa-ku, Tokyo, 142-0054, Japan; 3Global Clinical Operations,
Goi N +4 more
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Role of Dual Energy CT Scan in Evaluation of the Chemical Composition of Renal Stones [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: For appropriate management of renal stone knowing its composition is important. Laboratory chemical analysis of the stones involves sophisticated techniques.
Sachin Khanduri +7 more
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