Results 11 to 20 of about 49,829 (291)

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

eLife, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms ...
Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning   +6 more
doaj   +1 more source

Production of recombinant human xCT (SLC7A11) and reconstitution in proteoliposomes for functional studies

Frontiers in Physiology, 2022
The plasma membrane transporter xCT belongs to the SLC7 family and has the physiological role of mediating the exchange of glutamate and cystine across the cell plasma membrane, being crucial for redox control.
Michele Galluccio, Mariafrancesca Scalise, Gilda Pappacoda, Martina Scarpelli, Marcella Bonanomi, Marcella Bonanomi, Daniela Gaglio, Daniela Gaglio, Cesare Indiveri, Cesare Indiveri   +9 more
doaj   +1 more source

Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

Frontiers in Cell and Developmental Biology, 2021
Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy.
Sofia C. Nunes, Sofia C. Nunes, Cristiano Ramos, Cristiano Ramos, Inês Santos, Inês Santos, Cindy Mendes, Cindy Mendes, Fernanda Silva, Fernanda Silva, João B. Vicente, Sofia A. Pereira, Ana Félix, Ana Félix, Luís G. Gonçalves, Jacinta Serpa, Jacinta Serpa   +16 more
doaj   +1 more source

Cataracte d´arbre de Noël

PAMJ Clinical Medicine, 2020
Nous rapportons le cas d'un patient de 55 ans, sans antécédents pathologiques notables, qui consulte pour baisse d`acuité visuelle d'installation progressive.
Narjisse Taouri, Wafae Cherkaoui
doaj   +1 more source

Genetic Landscape of Nephropathic Cystinosis in Russian Children

Frontiers in Genetics, 2022
Nephropathic cystinosis is a rare autosomal recessive disorder characterized by amino acid cystine accumulation and caused by biallelic mutations in the CTNS gene.
K. V. Savostyanov, A. A. Pushkov, O. A. Shchagina, V. V. Maltseva, E. A. Suleymanov, I. S. Zhanin, N. N. Mazanova, A. P. Fisenko, P. S. Mishakova, A. V. Polyakov, E. V. Balanovska, R. A. Zinchenko, A. N. Tsygin   +12 more
doaj   +1 more source

Intracellular Distribution of Cystine in Cystine-Loaded Proximal Tubules [PDF]

Pediatric Research, 1994
Cellular cystine loading with cystine dimethyl ester has been shown to inhibit transport in proximal convoluted tubules perfused in vitro and decrease the rate of oxygen consumption in suspensions of proximal tubules. The present study was designed to examine the intracellular distribution of cystine in this model of the Fanconi syndrome of cystinosis ...
A, Sakarcan, C, Timmons, M, Baum
openaire   +2 more sources

Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR

Frontiers in Chemistry, 2020
Disulfide bridges establish a fundamental element in the molecular architecture of proteins and peptides which are involved e.g., in basic biological processes or acting as toxins. NMR spectroscopy is one method to characterize the structure of bioactive
Christoph Wiedemann, Amit Kumar, Andras Lang, Oliver Ohlenschläger   +3 more
doaj   +1 more source

Níveis de aminoácidos na dieta de suínos machos inteiros dos 25 aos 70KG Levels of aminoacids in diet for boars from 25 at 70KG

Ciência Rural, 1999
No Brasil, o abate de suínos machos inteiros é proibido, mas esta categoria apresenta vantagens econômicas quando comparada a suínos machos castrados. Trabalhos têm demonstrado que existem diferenças no requerimento nutricional entre essas categorias.
Cezar Dobler Castagna, Paulo Alberto Lovatto, Arlei Rodrigues Bonet de Quadros, Silvana Pedroso   +3 more
doaj   +1 more source

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

eLife, 2017
Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to ...
Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis, Matthew G Vander Heiden   +5 more
doaj   +1 more source

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

Antioxidants, 2017
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for ...
Gethin J. McBean
doaj   +1 more source