Results 11 to 20 of about 95,243 (337)

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology, 2021
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj   +1 more source

Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming

Frontiers in Cell and Developmental Biology, 2021
Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy.
Sofia C. Nunes, Sofia C. Nunes, Cristiano Ramos, Cristiano Ramos, Inês Santos, Inês Santos, Cindy Mendes, Cindy Mendes, Fernanda Silva, Fernanda Silva, João B. Vicente, Sofia A. Pereira, Ana Félix, Ana Félix, Luís G. Gonçalves, Jacinta Serpa, Jacinta Serpa   +16 more
doaj   +1 more source

Genetic Landscape of Nephropathic Cystinosis in Russian Children

Frontiers in Genetics, 2022
Nephropathic cystinosis is a rare autosomal recessive disorder characterized by amino acid cystine accumulation and caused by biallelic mutations in the CTNS gene.
K. V. Savostyanov, A. A. Pushkov, O. A. Shchagina, V. V. Maltseva, E. A. Suleymanov, I. S. Zhanin, N. N. Mazanova, A. P. Fisenko, P. S. Mishakova, A. V. Polyakov, E. V. Balanovska, R. A. Zinchenko, A. N. Tsygin   +12 more
doaj   +1 more source

Cataracte d´arbre de Noël

PAMJ Clinical Medicine, 2020
Nous rapportons le cas d'un patient de 55 ans, sans antécédents pathologiques notables, qui consulte pour baisse d`acuité visuelle d'installation progressive.
Narjisse Taouri, Wafae Cherkaoui
doaj   +1 more source

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
core   +2 more sources

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]

, 2011
Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey, Asrari, Barthel, Bègue-Kirn, Cabrera, Camargo, Doug Lobner, Duailibi, D’Souza, Fogal, Franco, Furey, Goldberg, Gronthos, Hansen, Hu, Kalyva, Katherine Pauly, Kaur, Keelan, Kim, Kim, Kymberly Fritz, Lobner, Lovschall, Marcato, Nie, Onishi, Pacheco, Paranjpe, Piani, Piattelli, Ricketts, Rutherford, Stanley, Stockton, Tziafas, Tziafas, Ward, Wood   +39 more
core   +2 more sources

The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells

Antioxidants, 2018
Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell.
Rodolfo Sumayao, Philip Newsholme, Tara McMorrow   +2 more
doaj   +1 more source

Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Journal of Pharmaceutical Analysis, 2021
Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown.
Shuning Li, Zhenyao Lu, Li Jiao, Ran Zhang, Yu Hong, Jiye Aa, Guangji Wang   +6 more
doaj   +1 more source

Intracellular Distribution of Cystine in Cystine-Loaded Proximal Tubules [PDF]

Pediatric Research, 1994
Cellular cystine loading with cystine dimethyl ester has been shown to inhibit transport in proximal convoluted tubules perfused in vitro and decrease the rate of oxygen consumption in suspensions of proximal tubules. The present study was designed to examine the intracellular distribution of cystine in this model of the Fanconi syndrome of cystinosis ...
A, Sakarcan, C, Timmons, M, Baum
openaire   +2 more sources

Urinary felinine excretion in intact male cats is increased by dietary cystine [PDF]

, 2008
Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. The objective of the present study was to determine if additional cystine and/or dietary N would increase felinine and N-acetylfelinine ...
Hendriks, W.H., Morton, R.H., Rogers, Q.R., Rutherfurd-Markwick, K.J., Weidgraaf, K.   +4 more
core   +2 more sources