Results 11 to 20 of about 27,857 (278)
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Protein & Cell, 2020 The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Li Zhuang, Boyi Gan
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eLife, 2014 Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive ...
Scott J Dixon +10 more
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eLife, 2017 Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to ...
Alexander Muir +5 more
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Role of Dual Energy CT Scan in Evaluation of the Chemical Composition of Renal Stones [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: For appropriate management of renal stone knowing its composition is important. Laboratory chemical analysis of the stones involves sophisticated techniques.
Sachin Khanduri +7 more
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bioRxiv, 2023 Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis.
Marine Berquez +11 more
semanticscholar +1 more source
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
Frontiers in Oncology, 2022 SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and
N. Jyotsana +2 more
semanticscholar +1 more source
Cancer Research, 2022 Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by ...
Xiuchao Wang +15 more
semanticscholar +1 more source
Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. [PDF]
PLoS ONE, 2015 Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC.
Iwao Ohtsu +7 more
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Molecular basis for redox control by the human cystine/glutamate antiporter system xc−
Nature Communications, 2021 Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as
J. L. Parker +6 more
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Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006‐2018)
Journal of Veterinary Internal Medicine, 2021 Background Urolithiasis is a common and often recurrent problem in dogs. Objective To evaluate trends in urolith composition in dogs and to assess risk factors for urolithiasis, including age, breed, sex, neuter status, urolith location, and bacterial ...
Lucy Kopecny +3 more
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