Results 11 to 20 of about 112,393 (379)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Protein & Cell, 2020
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.
Pranavi Koppula, Li Zhuang, Boyi Gan
doaj   +2 more sources

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

eLife, 2014
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive ...
Scott J Dixon, Darpan N Patel, Matthew Welsch, Rachid Skouta, Eric D Lee, Miki Hayano, Ajit G Thomas, Caroline E Gleason, Nicholas P Tatonetti, Barbara S Slusher, Brent R Stockwell   +10 more
doaj   +2 more sources

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

eLife, 2017
Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to ...
Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis, Matthew G Vander Heiden   +5 more
doaj   +2 more sources

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer

Frontiers in Oncology, 2022
SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and
N. Jyotsana, Kenny T. L. Ta, Kathleen E. DelGiorno   +2 more
semanticscholar   +1 more source

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

bioRxiv, 2023
Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis.
Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn, S. Keller, S. Parolo, M. Korzinkin, A. Gaponova, E. Laczko, E. Domenici, O. Devuyst, A. Luciani   +11 more
semanticscholar   +1 more source

Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer.

Cancer Research, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by ...
Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj Singh, N. Hempel, M. Trebak, G. DeNicola, J. Hao, Shengyu Yang   +15 more
semanticscholar   +1 more source

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

Nature Communications, 2021
Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as
J. L. Parker, J. Deme, D. Kolokouris, Gabriel Kuteyi, P. Biggin, S. Lea, S. Newstead   +6 more
semanticscholar   +1 more source

CISD3 inhibition drives cystine-deprivation induced ferroptosis

Cell Death and Disease, 2021
Ferroptosis, a new form of programmed cell death, not only promotes the pathological process of various human diseases, but also regulates cancer progression. Current perspectives on the underlying mechanisms remain largely unknown.
Yanchun Li, Xin Wang, Zhihui Huang, Yi Zhou, Jun Xia, Wanye Hu, Xu Wang, Jing Du, Xiangmin Tong, Ying Wang   +9 more
semanticscholar   +1 more source

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Nature Cell Biology, 2020
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11.
Xiaoguang Liu, Kellen L. Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, L. Zhuang, M. J. You, B. Fang, Wei Li, Christian M. Metallo, M. Poyurovsky, B. Gan   +16 more
semanticscholar   +1 more source

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Nature Communications, 2021
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth.
Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Y. Zou   +3 more
semanticscholar   +1 more source