Results 21 to 30 of about 27,857 (278)
CISD3 inhibition drives cystine-deprivation induced ferroptosis
Cell Death and Disease, 2021 Ferroptosis, a new form of programmed cell death, not only promotes the pathological process of various human diseases, but also regulates cancer progression. Current perspectives on the underlying mechanisms remain largely unknown.
Yanchun Li +9 more
semanticscholar +1 more source
Biomarkers in Nephropathic Cystinosis: Current and Future Perspectives
Cells, 2022 Early diagnosis and effective therapy are essential for improving the overall prognosis and quality of life of patients with nephropathic cystinosis. The severity of kidney dysfunction and the multi-organ involvement as a consequence of the increased ...
Francesco Emma +9 more
doaj +1 more source
Nature Cell Biology, 2020 SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11.
Xiaoguang Liu +16 more
semanticscholar +1 more source
Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
Nature Communications, 2021 The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth.
Zhennan Shi +3 more
semanticscholar +1 more source
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj +1 more source
Frontiers in Physiology, 2022 The plasma membrane transporter xCT belongs to the SLC7 family and has the physiological role of mediating the exchange of glutamate and cystine across the cell plasma membrane, being crucial for redox control.
Michele Galluccio +9 more
doaj +1 more source
Scientific Reports, 2021 We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME) on morphine-
B. Gaston +8 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Among gynecologic malignancies, ovarian cancer is the third most prevalent and the most common cause of death, especially due to diagnosis at an advanced stage together with resistance to therapy.
Sofia C. Nunes +16 more
doaj +1 more source
The Impact of Diet on Urinary Risk Factors for Cystine Stone Formation
Nutrients, 2021 Despite the importance of dietary management of cystinuria, data on the contribution of diet to urinary risk factors for cystine stone formation are limited.
R. Siener +3 more
semanticscholar +1 more source
eLife, 2021 The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms ...
Margaret E Torrence +6 more
doaj +1 more source