Results 41 to 50 of about 49,829 (291)

Atypical onset of nephropathic infantile cystinosis in a Russian patient with rare CTNS mutation

Clinical Case Reports, 2018
Key Clinical Message We report a Russian patient with atypical onset of infantile nephropathic cystinosis. The disease debuted with vomiting and loss of weight and motor skills. Nephropathic changes appeared 6 months after onset of disease.
Kozina A. Anastasiya, Okuneva G. Elena, Baryshnikova V. Natalia, Krasnenko Yu. Anna, Tsukanov Yu. Kirill, Klimchuk I. Olesya, Nikishina A. Tatiana, Fedoniuk D. Inessa, Surkova I. Ekaterina, Shatalov A. Peter, Ilinsky V. Valery   +10 more
doaj   +1 more source

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

eLife, 2014
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive ...
Scott J Dixon, Darpan N Patel, Matthew Welsch, Rachid Skouta, Eric D Lee, Miki Hayano, Ajit G Thomas, Caroline E Gleason, Nicholas P Tatonetti, Barbara S Slusher, Brent R Stockwell   +10 more
doaj   +1 more source

Quantitation of L-cystine in Food Supplements and Additives Using ¹H qNMR: Method Development and Application

Foods, 2023
Cystine-enriched food supplements are increasingly popular due to their beneficial health effects. However, the lack of industry standards and market regulations resulted in quality issues with cystine food products, including cases of food adulteration ...
Zhen Chen, Xiaofang Lian, Meichen Zhou, Xiuli Zhang, Cong Wang   +4 more
doaj   +1 more source

Engineering Dimensional Configuration of Single‐Atom S‐Cu‐S Sites as Reversible Electron Station for Enhanced Peroxidase‐Mimicking

Advanced Science, EarlyView.
L‐cysteine triggers auto‐assembly of POD‐like 3D biomimetic S‐Cu‐S single‐atom nanozymes on MoS2 (MoCC). MoCC shows 16.3‐fold higher catalytic velocity and 17.9‐fold greater affinity than HRP, enabling efficient •OH generation via enhanced electron inversion and transfer.
Wenjie Ma, Qian He, Jiancheng Sun, Yiqing Chen, Hongfei Su, Ludan Zhang, Xiao He, Yuguang Wang, Changjian Xie, Zhiyong Zhang, Xin Zhou, Yuliang Zhao, Wenyan Yin   +12 more
wiley   +1 more source

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, EarlyView.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source

Gas-Phase Fragmentation Reactions of Protonated Cystine using High-Resolution Tandem Mass Spectrometry

Molecules, 2019
Cystine is an important biomolecule in living systems. Although collision-induced dissociation (CID)-based tandem mass spectrometry (MS/MS) is commonly applied for identification and quantification of cystine in both biomedical and nutritional studies ...
Pengwei Zhang, Wan Chan, Irene L. Ang, Rui Wei, Melody M. T. Lam, Kate M. K. Lei, Terence C. W. Poon   +6 more
doaj   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, EarlyView.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source

Grafting Cell‐Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery

Angewandte Chemie, EarlyView.
Grafting‐to rather than the grafting‐from strategy envisioned 10 years ago is shown to make cell‐penetrating poly(disulfide)s compatible with dynamic covalent bioconjugation at high dilution (50 nM) and top rates (1500 M−1s−1), genetic engineering and transduction domains, that is traceless tags for protein delivery, including intact functional anti ...
Michael Cognet, Giacomo Renno, Filipe Coelho, Naomi Sakai, Stefan Matile   +4 more
wiley   +2 more sources

Selective, Simple and Economical Method for the Voltammetric Determination of Bi(III) in the presence Cystine in Non – Complexing Solution

E3S Web of Conferences, 2013
The simple and fast method for the determination of Bi(III) in non-complexing solution was proposed. The catalytic activity of cystine on Bi(III) ions electroreduction process were utilized.
Nosal –Wiercińska A., Grochowski M., Tyszczuk–Rotko K., Skrzypek S., Guziejewski D.   +4 more
doaj   +1 more source