Results 41 to 50 of about 112,393 (379)

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance xCT, the cystine–glutamate antiporter, has been implicated in supporting both tumor growth and T cell proliferation; thus, antitumor effects of systemic xCT inhibition may be blunted by compromised antitumor immunity. This report details the
Michael D. Arensman, Xiaoran S. Yang, D. Leahy, L. Toral‐Barza, Mary Mileski, E. Rosfjord, F. Wang, Shibing Deng, Jeremy S. Myers, R. Abraham, Christina H. Eng   +10 more
semanticscholar   +1 more source

Effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids [PDF]

, 1974
The effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids was studied and the following results were obtained.
Ikegami, T., Kodama, H., Oura, T., Yao, K.   +3 more
core   +1 more source

Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses.

Cancer Research, 2019
Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues.
Boutaina Daher, S. Parks, J. Durivault, Yann Cormerais, Hanane Baidarjad, É. Tambutté, J. Pouysségur, M. Vucetic   +7 more
semanticscholar   +1 more source

Níveis de aminoácidos na dieta de suínos machos inteiros dos 25 aos 70KG Levels of aminoacids in diet for boars from 25 at 70KG

Ciência Rural, 1999
No Brasil, o abate de suínos machos inteiros é proibido, mas esta categoria apresenta vantagens econômicas quando comparada a suínos machos castrados. Trabalhos têm demonstrado que existem diferenças no requerimento nutricional entre essas categorias.
Cezar Dobler Castagna, Paulo Alberto Lovatto, Arlei Rodrigues Bonet de Quadros, Silvana Pedroso   +3 more
doaj   +1 more source

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources

DETOXICATION OF CYANIDE BY CYSTINE

Journal of Biological Chemistry, 1956
SUMMARY Chemical studies on the nature of the reaction product between cystine and cyanide ion support formulation of the structure as 2-imino-4-thiazoli- dinecarboxylic acid. The compound was inert metabolically when fed to the rat or when injected. On treatment with acid, a small amount of thio- cyanate was produced.
Shirley Lucille Cooley, John L. Wood
openaire   +3 more sources

Update on cystine stones: current and future concepts in treatment.

Intractable & Rare Diseases Research, 2020
Cystine stones are relatively uncommon compared with other stone compositions, constituting just 1% to 2% of adult urinary tract stone diseases, and accounting for up to 10% of pediatric stone diseases.
M. Moussa, A. Papatsoris, M. Abou Chakra, Y. Moussa   +3 more
semanticscholar   +1 more source

Cystine nephrolithiasis: contemporary approaches to patient management

Вестник урологии
Introduction. Cystinuria is a rare genetic disorder characterised by a markedly elevated concentration of cystine in the urine. Due to the low solubility of cystine in urine, patients with cystinuria face a lifelong increased risk of urinary stone ...
V. A. Gelig, E. I. Leonova, D. S. Gorelov, I. V. Semenyakin, N. K. Gadzhiev   +4 more
doaj   +1 more source

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

Antioxidants, 2017
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for ...
Gethin J. McBean
doaj   +1 more source

Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells

Cell Death and Disease
Cancer cells develop multiple strategies to evade T cell-mediated killing. On one hand, cancer cells may preferentially rely on certain amino acids for rapid growth and metastasis.
Chenfeng Han, Minmin Ge, Pengfei Xing, Tian Xia, Cangang Zhang, Kaili Ma, Yifu Ma, Shicheng Li, Wenhui Li, Xiaowei Liu, Baojun Zhang, Liyuan Zhang, Lianjun Zhang   +12 more
semanticscholar   +1 more source