Results 41 to 50 of about 27,857 (278)

Antioxidant and Anti-Urolithiatic Activity of Aqueous and Ethanolic Extracts from Saussurea costus (Falc) Lispich Using Scanning Electron Microscopy

Life, 2022
The plant Saussurea costus (Falc) Lipsch has many biological activities and a strong curative and preventive power against a variety of diseases including cancer, diabetes, and hemorrhoids. In the current study, phytochemical screening was carried out as
Naima Mammate, Fatima Ezzahra El oumari, Hamada Imtara, Salim Belchkar, Anissa Lahrichi, Ali S. Alqahtani, Omar M. Noman, Mahmoud Tarayrah, Tarik Sqalli Houssaini   +8 more
doaj   +1 more source

Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc− for Glutathione Synthesis in Lung Cancer

Cancer Research, 2020
Cellular GSH in cancer cells is not only determined by upregulated Xc− but also by dysregulated glutamate transporters, which provide additional targets for therapeutic intervention.
Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, F. Yao, Binhua P. Zhou, Shu-hai Lin, Jiong Deng   +20 more
semanticscholar   +1 more source

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

Antioxidants, 2017
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for ...
Gethin J. McBean
doaj   +1 more source

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance RAS genes are among the most mutated proto-oncogenes in human cancer. The mechanisms supporting RAS transformation are not fully understood, particularly regarding the relative contributions of oxidant versus antioxidant pathways.
Jonathan K. M. Lim, A. Delaidelli, Sean W. Minaker, Hai-Feng Zhang, M. Čolović, Hua Yang, G. Negri, S. von Karstedt, W. Lockwood, P. Schaffer, G. Leprivier, P. Sorensen   +11 more
semanticscholar   +1 more source

The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells

Antioxidants, 2018
Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell.
Rodolfo Sumayao, Philip Newsholme, Tara McMorrow   +2 more
doaj   +1 more source

Estimation of urinary stone composition by automated processing of CT images [PDF]

Urological Research (2009) epub ahead of print, 2009
The objective of this article was developing an automated tool for routine clinical practice to estimate urinary stone composition from CT images based on the density of all constituent voxels. A total of 118 stones for which the composition had been determined by infrared spectroscopy were placed in a helical CT scanner.
arxiv   +1 more source

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance xCT, the cystine–glutamate antiporter, has been implicated in supporting both tumor growth and T cell proliferation; thus, antitumor effects of systemic xCT inhibition may be blunted by compromised antitumor immunity. This report details the
Michael D. Arensman, Xiaoran S. Yang, D. Leahy, L. Toral‐Barza, Mary Mileski, E. Rosfjord, F. Wang, Shibing Deng, Jeremy S. Myers, R. Abraham, Christina H. Eng   +10 more
semanticscholar   +1 more source

Cystine import is a valuable but risky process whose hazards Escherichia coli minimizes by inducing a cysteine exporter

Molecular Microbiology, 2020
The structure of free cysteine makes it vulnerable to oxidation by molecular oxygen; consequently, organisms that live in oxic habitats have acquired the ability to import cystine as a sulfur source.
S. Korshunov, K. Imlay, J. Imlay
semanticscholar   +1 more source

Cystine Stones: Developments in Minimally Invasive Surgery and Their Impact on Morbidity and Stone Clearance

Research and Reports in Urology, 2023
Thomas Hughes,1 Lazaros Tzelves,2 Bhaskar K Somani3 1Department of Urology, Warwick Hospital, Warwick, UK; 2Department of Urology, Sismanogleio Hospital, National and Kapodistrian University of Athens, Athens, Greece; 3Department of Urology, University ...
Hughes T, Tzelves L, Somani BK
doaj  

Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses.

Cancer Research, 2019
Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues.
Boutaina Daher, S. Parks, J. Durivault, Yann Cormerais, Hanane Baidarjad, É. Tambutté, J. Pouysségur, M. Vucetic   +7 more
semanticscholar   +1 more source