Results 81 to 90 of about 47,323 (291)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients

Orphanet Journal of Rare Diseases, 2011
Background Nephropathic cystinosis is an autosomal recessive disorder resulting in an impaired transport of cystine trough the lysosomal membrane causing an accumulation of free cystine in lysosomes.
Bouazza Naïm, Tréluyer Jean-Marc, Ottolenghi Chris, Urien Saik, Deschenes Georges, Ricquier Daniel, Niaudet Patrick, Chadefaux-Vekemans Bernadette   +7 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Digestible methionine plus cystine requirement in tambaqui (Colossoma macropomum) diets: Growth performance and plasma biochemistry

Aquaculture Reports, 2023
Most animals require methionine as an indispensable amino acid in their dietary protein, the normal growth of animals being affected by any deficiency or excess of methionine and cystine in the diet.
Rômulo Jordão Neves Aroucha, Felipe Barbosa Ribeiro, Marcos Antonio Delmondes Bomfim, Jefferson Costa de Siqueira, Rafael Silva Marchão, Dáphinne Cardoso Nagib do Nascimento   +5 more
doaj  

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Phytochemical Contents and Bioactive Compounds in Widely Consumed Cereals, Legumes, and Vegetables in Abruzzo Region, Italy: A Critical Review

Food Safety and Health, EarlyView.
This review aims to collect and identify cereals, legumes, and vegetables mostly consumed in the Abruzzo region from 2020 till now, pointing attention to their biological effects. ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet,
Giulia Gentile, Lorenza Marinaccio, Adriano Mollica, Azzurra Stefanucci   +3 more
wiley   +1 more source

Tannin: An Insight into its Cosmeceutical Properties and Uses

Global Challenges, EarlyView.
Filling a gap in the literature, this study identifies the emerging uses of tannin as cosmeceutical ingredient in skin and hair care products. The account offers also a green chemistry, health and economic perspective on future developments concerning the use of tannins in cosmetic products widely employed worldwide such as hair dyes and hair relaxers.
Rosaria Ciriminna, Giovanna Li Petri, Giuseppe Angellotti, Enrica Fontananova, Francesco Meneguzzo, Rafael Luque, Mario Pagliaro   +6 more
wiley   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Hyperglycemia Aggravates 6-Hydroxydopamine-Induced Neuronal Ferroptosis via SLC7A11-Dependent Pathway in Diabetic PD Rat Model. [PDF]

CNS Neurosci Ther
Chronic hyperglycemia disrupts the cystine/SLC7A11/glutathione axis, impairing cystine uptake and depleting glutathione in dopaminergic neurons, increasing ferroptosis susceptibility. SLC7A11 restoration rescues neuronal viability, restores redox balance, and attenuates neurodegeneration in diabetic PD models. SLC7A11 emerges as a therapeutic target to
Zhao Y, Wang D, Wang Y, Mu D, Qu L, Li R.   +5 more
europepmc   +2 more sources