Results 191 to 200 of about 56,630 (276)

A 4′‐Thioribouridine Modification Mimics 2′‐O‐Methoxyethyl in ASO‐Like 20‐Mers Targeting PTEN Knockdown

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A 4′‐thiouridine phosphoramidite was prepared and site‐selectively incorporated into PTEN‐targeting gapmer ASOs. Flank‐modified gapmers with defined phosphorothioate linkage patterns maintained potent target knockdown under transfection and gymnotic delivery, matching 2′‐O‐methoxyethyl comparators and highlighting 4′‐thioribose as a valuable motif for ...
Joanna E. Parkes, Caecilie M. M. Benckendorff, Anna L. Malinowska, Jacob Roberts, Harley L. Huynh, Sritama Bose, Loïc M. Cochard, Aisling Ní Cheallaigh, Sarah L. Lovelock, Peter L. Oliver, Gavin J. Miller   +10 more
wiley   +1 more source

Hypoxia Independently Induces AID Expression in CH12 B Cells. [PDF]

Eur J Immunol
Heyer V, Haidar Ahmad S, Haddad M, Argentieri I, Gessier C, Reina-San-Martin B.   +5 more
europepmc   +1 more source

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando, Laora Boulo, Léonid Lavnevich, Elisa Teyssou, Stéphane Marot, Adélie Gothland, Jean‐Michel Guigner, Anne‐Geneviève Marcelin, Mickaël Ménand, Vincent Calvez, Matthieu Sollogoub   +10 more
wiley   +2 more sources

THE SYNTHESIS OF CYTIDINE DIPHOSPHATE CHOLINE, CYTIDINE DIPHOSPHATE ETHANOLAMINE, AND RELATED COMPOUNDS

Journal of Biological Chemistry, 1956
openaire   +2 more sources

A hybrid RNA-based reporter assay for robust quantification of cytidine deaminase activity. [PDF]

Nucleic Acids Res
Ligasová A, Horejšová M, Friedecký D, Pokorná E, Klener P, Koberna K.   +5 more
europepmc   +1 more source

Conformationally Constrained Phosphonate Backbone Linkages Enhance CpG Oligonucleotide Activation of Toll-Like Receptor 9. [PDF]

ACS Pharmacol Transl Sci
Kóšiová I, Štěpánek I, Šimák O, Kostov O, Petrová M, Páv O, Rejman D, Liboska R, Buděšínský M, Rosenbergová Š, Birkuš G, Rosenberg I.   +11 more
europepmc   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells. [PDF]

Proc Natl Acad Sci U S A
Puzon A, Raval A, Cordero C, Schiefen D, Mieczkowski PA, Roberts SA, Mertz TM.   +6 more
europepmc   +1 more source

Synergistic Application of Cytidine Monophosphate and Sodium Chloride for Enhanced Co-Production of Astaxanthin and Fatty Acids in <i>Haematococcus lacustris</i> Motile Cells Under High-Light Stress. [PDF]

Mar Drugs
Su X, Xing H, Liu K, Zhao Y, Dong L, Zhou Z, Zhou N, Sun X, Zhang L, Xu N, Hu C.   +10 more
europepmc   +1 more source

Substrate selectivity of the human RNA m⁵C methyltransferase NSUN2. [PDF]

Nature
Canepa J, Ruiz-Arroyo VM, Schlamowitz NS, Nam Y.   +3 more
europepmc   +1 more source