Results 171 to 180 of about 80,345 (286)

Emerging roles of mRNA acetylation in plants. [PDF]

Plant Commun
Zhao J, Zhu C, Song X, Chen M.
europepmc   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

hnRNPA2B1 induces HBV cccDNA degradation by recruiting APOBEC3B. [PDF]

Nucleic Acids Res
Fu Z, Wang L, Sun Y, Ren C, Dou Y, Wang K, Fan Y, Yue X, Li C, Gao L, Liang X, Ma C, Wu Z.   +12 more
europepmc   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Uridine-cytidine kinase 2 as a novel potential prognostic and therapeutic biomarker in gastric cancer. [PDF]

Transl Cancer Res
Sun W, Guo H, Cai M, Ma G, Zhang L, Yu Y, Zhan H.   +6 more
europepmc   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, Volume 13, Issue 27, 13 May 2026.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Mechanisms of APOBEC3 Packaging into HIV-1. [PDF]

Viruses
Nzivo M, Gertzen CGW, Luedde T, Gohlke H, Münk C.   +4 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA-Ligand Interactions. [PDF]

J Am Chem Soc
Sudakov A, Becker-Baldus J, Mineev KS, Wacker A, Jonker HRA, Nussbaumer F, Plangger R, Glaubitz C, Schwalbe H.   +8 more
europepmc   +1 more source

RELB Overexpression Induced by DNA Hypomethylation Contributes to Perioperative Immunotherapy Resistance in Resectable Esophageal Squamous Cell Carcinoma by Modulating the mregDC‐Treg Axis

Cancer Medicine, Volume 15, Issue 5, May 2026.
In patients with resectable ESCC, DNA hypomethylation driven RELB overexpression promotes resistance to perioperative immunotherapy (neoadjuvant ICIs followed by surgery and adjuvant ICIs). High RELB expression correlates with increased infiltration of mature immunoregulatory dendritic cells (mregDCs) and regulatory T cells (Tregs) in the tumor ...
Lijuan Gao, Shaobo Ke
wiley   +1 more source