Results 171 to 180 of about 46,251 (223)
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Phosphorylation of uridine and cytidine by uridine–cytidine kinase
Journal of Biotechnology, 2014Uridine 5'-monophosphate (5'-UMP) and cytidine 5'-monophosphate (5'-CMP) were biosynthesized by recombinant uridine-cytidine kinase (UCK) and acetate kinase (ACK). The ack and uck genes from Escherichia coli K12 and the uck1, uck2 and ack genes from Lactobacillus bulgaricus ATCC 11842 were cloned and inserted into the plasmid pET-28a.
Yahui Qian, Qingbao Ding, Zhi Zou
exaly +3 more sources
Solvolyses of Cytosine and Cytidine
Journal of Pharmaceutical Sciences, 1972It has been confirmed by UV spectrophotometry and TLC that cytosine and cytidine deaminate to uracil and uridine, respectively, at all pH values. These products slowly degrade further in strongly alkaline solutions. Cytidine also undergoes a parallel degradation in strongly alkaline solutions to a nonchromophoric compound, which can be assigned to a ...
Edward R Garrett
exaly +3 more sources
Biopolymers, 1971
AbstractThe large change in the electronic absorption spectrum of cytidine on going from an aqueous to an aprotic medium is attributed to the existence of a hydrogen bonded solvent‐solute complex in solvents capable of donating a proton. The spectrum of cytidine in a variety of solvents and the spectra of a number of nontautomerising model compounds ...
W C, Johnson, P M, Vipond, J C, Girod
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AbstractThe large change in the electronic absorption spectrum of cytidine on going from an aqueous to an aprotic medium is attributed to the existence of a hydrogen bonded solvent‐solute complex in solvents capable of donating a proton. The spectrum of cytidine in a variety of solvents and the spectra of a number of nontautomerising model compounds ...
W C, Johnson, P M, Vipond, J C, Girod
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Carbohydrate Research, 1984
Abstract A practical, seven-step synthesis of 5-(β- d -ribofuranosyl)cytosine ( 1 , ψ-cytidine) was achieved. ψ-Uridine was converted into the 2′,3′-isopropylidene acetal 2 in 85% yield. Tosylation of 2 to the 5′-sulfonate 3 , followed by deacetonation, afforded 5′- O -tosyl-ψ-uridine ( 6 ) in good yield.
K W, Pankiewicz +3 more
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Abstract A practical, seven-step synthesis of 5-(β- d -ribofuranosyl)cytosine ( 1 , ψ-cytidine) was achieved. ψ-Uridine was converted into the 2′,3′-isopropylidene acetal 2 in 85% yield. Tosylation of 2 to the 5′-sulfonate 3 , followed by deacetonation, afforded 5′- O -tosyl-ψ-uridine ( 6 ) in good yield.
K W, Pankiewicz +3 more
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Journal of Molecular Biology, 1972
Abstract Between 15 and 30 °C, conversion of cytidine to the 2′, 3′- or 5′-phosphate increases the reactivity towards methoxyamine by twofold or less in both addition to the double bond at C-6 and substitution of the amino group at C-4. With dinucleoside monophosphates, addition is slower than with cytidine 2′(3′) phosphate and is usually slower than
A, Steinschneider, B, Leshem
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Abstract Between 15 and 30 °C, conversion of cytidine to the 2′, 3′- or 5′-phosphate increases the reactivity towards methoxyamine by twofold or less in both addition to the double bond at C-6 and substitution of the amino group at C-4. With dinucleoside monophosphates, addition is slower than with cytidine 2′(3′) phosphate and is usually slower than
A, Steinschneider, B, Leshem
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A ribozyme that lacks cytidine
Nature, 1999The RNA-world hypothesis proposes that, before the advent of DNA and protein, life was based on RNA, with RNA serving as both the repository of genetic information and the chief agent of catalytic function. An argument against an RNA world is that the components of RNA lack the chemical diversity necessary to sustain life.
J, Rogers, G F, Joyce
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An Overview of Cytidine Deaminases
International Journal of Hematology, 2006Enzymes that deaminate cytidine to uridine play an important role in a variety of pathways from bacteria to man. Ancestral members of this family were able to deaminate cytidine only in a mononucleotide or nucleoside context. Recently, a family of enzymes has been discovered with the ability to deaminate cytidines on RNA or DNA.
Naveenan, Navaratnam, Rizwan, Sarwar
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