Results 151 to 160 of about 80,345 (286)

Precision Medicine in a Patient With Multiple Myeloma Presenting With t(2;11) and CCND1 Overexpression

open access: yeseJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Translocations involving CCND1 are well described in multiple myeloma (MM), most frequently t(11;14), but rearrangements involving the immunoglobulin kappa (IGK) locus are rare. We present a case of a 71‐year‐old female with MM harboring t(2;11)(p11.2;q13), resulting in IGK::CCND1, with cyclin D1 and BCL‐2 overexpression.
Ariel Siegel   +7 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

open access: yesMedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li   +6 more
wiley   +1 more source

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

open access: yesAngewandte Chemie, Volume 138, Issue 20, 11 May 2026.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova   +2 more
wiley   +2 more sources

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang   +7 more
wiley   +1 more source

Genome Editing in Root and Tuber Crop Development in Sub‐Saharan Africa

open access: yesPlant-Environment Interactions, Volume 7, Issue 3, June 2026.
ABSTRACT Precision genome editing, particularly using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9), is advancing crop improvement by enabling targeted and efficient genetic modifications. Root and tuber crops such as potato, cassava, sweet potato, and yam are vital for global food and nutritional
Himanshu Saini   +8 more
wiley   +1 more source

Kinetic mechanism of cytidine aminohydrolase [PDF]

open access: yesBiochemical Journal, 1970
J D, Findlater   +3 more
openaire   +2 more sources

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