Results 201 to 210 of about 80,345 (286)

Neurostructural alterations, trait impulsivity, and genetic architecture in individuals with methamphetamine dependence: a multimodal imaging-genetics study. [PDF]

Transl Psychiatry
Luo D, Shen D, Ran J, Luo H, Zhang J, Tang Q, Lai M, Xu J, Li J.   +8 more
europepmc   +1 more source

Retrotransposons in Bone and Joint Diseases

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
This graphical abstract illustrates how epigenetic erosion during aging and disease reactivates retrotransposons, particularly endogenous retroviruses (ERVs), in musculoskeletal tissues. Their activation induces viral and molecular mimicry, triggering innate and adaptive immune responses and promoting cellular senescence.
Ye Liu, H. Josh Jang, Tao Yang
wiley   +1 more source

A Pharmacogenomic Basis for Tolerance of 5-Fluorouracil Following Early, Severe Toxicity from Capecitabine in a CDA Ultrarapid Metabolizer Colon Cancer Patient: A Case Report. [PDF]

Cancer Manag Res
Mazhindu TA, Chikwambi Z, Matsikidze E, Grimes KV, Borok MZ, Ndlovu N, Masimirembwa C, Consortium for Genomics and Therapeutics in Africa.   +7 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

CRISPR-Cas based plasmid design for multidrug-resistant Klebsiella pneumoniae isolates. [PDF]

FEMS Microbiol Lett
Baba S, Oncul O, Aktas Z.
europepmc   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Longitudinal characterization of mature beef bull seminal fluid and blood serum metabolome during a 65-day breeding season. [PDF]

Transl Anim Sci
Williams JD, Crouse MS, La Frano MR, Campos-Chillòn LF, Cunningham-Hollinger HC, Field CE, McFarlane ZD.   +6 more
europepmc   +1 more source

B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) is increasingly recognized not just as a lipid‐driven disease, but as a complex interplay between vascular cells and the immune system. Accumulating evidence highlights a central, yet heterogeneous role for B cells in atherogenesis, with distinct subsets displaying opposing roles.
Sophieke Lems, Megan Grace Mazzei, Amanda C. Foks, Coleen A. McNamara   +3 more
wiley   +1 more source

Structures of pentatricopeptide repeat proteins. [PDF]

Acta Crystallogr F Struct Biol Commun
Pullakhandam A, Cooper C, Small ID, Bond CS.   +3 more
europepmc   +1 more source

Sialidase Neu3 Induced Sialic Acid Disorder and Promoted Vascular Endothelial Injury Through Transcription Factor SP3

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Atherosclerotic cardiovascular disease is still a major cause for the increasing mortality worldwide. The elevated metabolite N‐acetylneuraminic acid (Neu5Ac) was considered one of the important risk factors responsible for the initiation of endothelial impairment, then participated in atherosclerosis progression.
Yining Lu, Peng Xiang, Qingqiu Chen, Xianmin Wang, Le Chen, Tongchuan Wang, Rong Hu, Limei Ma, Chao Yu   +8 more
wiley   +1 more source