Results 71 to 80 of about 100,040 (330)

Cytidine does not affect acute toxicity of intravenously administered choline

Folia Neuropathologica
Cytidine-5’-diphosphocholine (CDP-choline) is a key precursor for the intracellular synthesis of phosphatidylcholine and other phospholipids. Following either intravenous or oral application citicoline (CDP-choline of exogenous origin) undergoes quick ...
Kamil Synoradzki, Maciej Swiatkiewicz, Paweł Grieb   +2 more
doaj   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

The Escherichia coli transcriptome mostly consists of independently regulated modules [PDF]

, 2019
Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators.
A Anand, A Biton, A Delorme, A Frigyesi, A Hyvärinen, A Santos-Zavaleta, A-M Martoglio, AE Teschendorff, B Dalrymple, B Langmead, B-K Cho, B-K Cho, BM Bolstad, C Vijayendran, CL Turnbough Jr, D Kim, D Marbach, D Risso, D-S Huang, DS Latchman, E Nudler, EJ O’Brien, ENCODE Project Consortium., ER Gansner, F Pedregosa, GI Guzmán, GI Guzmán, H Zou, HS Rhee, I Kristoficova, IM Keseler, J Pouyssegur, J Utrilla, JE Galagan, JJ Faith, JM Buescher, JM Engreitz, JM Monk, JT Leek, K Valgepea, K-K Yan, KF Jensen, KJ Karczewski, L Wang, M Ester, M Kim, M Lawrence, M Moretto, M Scott, M Scott, MB Gerstein, MI Love, NE Lewis, O Alter, P Chiappetta, P Comon, PR Subbarayan, PV Phaneuf, R De Smet, R Kolter, RA LaCroix, RB D’agostino, S Gama-Castro, S Lin, SJ Larsen, SW Seo, T Baba, T Barrett, TM Henkin, W Kong, W Liebermeister, W Saelens, X Zhang, Xin Fang, XW Zhang, Y Gao, Y Yamanaka, Z Wang   +77 more
core   +3 more sources

RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2014
The eukaryotic small-subunit (SSU) ribosomal RNA (rRNA) has two evolutionarily conserved acetylcytidines. However, the acetylation sites and the acetyltransferase responsible for the acetylation have not been identified.
Masato Taoka, Daisuke Ishikawa, Yuko Nobe, Hideaki Ishikawa, Yoshio Yamauchi, Goro Terukina, Hiroshi Nakayama, Kouji Hirota, Nobuhiro Takahashi, Toshiaki Isobe   +9 more
doaj   +1 more source

APOBEC3s: DNA‐editing human cytidine deaminases

Protein Science, 2019
Nucleic acid editing enzymes are essential components of the human immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins.
Tania V. Silvas, C. Schiffer
semanticscholar   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Mutant loxP vectors for selectable marker recycle and conditional knock-outs [PDF]

, 2001
BACKGROUND: Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration
Arakawa, Hiroshi, Buerstedde, Jean-Marie, Lodygin, Dimitry   +2 more
core   +3 more sources

ParB spreading on DNA requires cytidine triphosphate in vitro

bioRxiv, 2019
In all living organisms, it is essential to transmit genetic information faithfully to the next generation. The SMC-ParAB-parS system is widely employed for chromosome segregation in bacteria.
Adam S. B. Jalal, N. Tran, T. Le
semanticscholar   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

The accumulation of orotic acid by a pyrimidineless mutant of Neurospora [PDF]

, 1948
The discovery of orotic acid (1,2-carboxyuracil) in cow's milk by Biscaro and Belloni (1), followed by its identification and synthesis (2-4), led to a number of speculations as to its biological origin and significance (,3,5,6).
Houlahan, Mary B., Mitchell, Herschel K., Nyc, Joseph F.   +2 more
core