Results 231 to 240 of about 30,295 (249)

Activation-induced cytidine deaminase and active cytidine demethylation

Trends in Biochemical Sciences, 2015
The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome ...
Almudena R, Ramiro, Vasco M, Barreto
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Human Cytidine Deaminase: Understanding the Catalytic Mechanism

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
COSTANZI S, VINCENZETTI, Silvia, VITA, Alberto, LAMBERTUCCI, Catia, TAFFI S, VOLPINI, Rosaria, VITTORI, Sauro, CRISTALLI, Gloria   +7 more
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Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase.

Nucleosides and Nucleotides, 1996
Abstract The synthesis of 2′-deoxy and 2′,3′-dideoxy derivatives of 1-s-D-ribofuranosyl-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (2) was undertaken in order to find new cytidine deaminase (CDA) inhibitors and potential adjuvants in anticancer chemotherapy.
G. Cristalli, R. Volpini, S. Vittori, CAMAIONI, Emidio, G. Rafaiani, S. Potenza, A. Vita   +6 more
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Crystal structure of Arabidopsis thaliana cytidine deaminase

Biochemical and Biophysical Research Communications, 2020
Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a number of RNA editing enzymes. Arabidopsis thaliana has only one functional CDA, AtCDA1. We solved
Jia Wang, Qi Guo, Lin Liu, Xiao Wang
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Activity of serum cytidine deaminase during pregnancy

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. A simple and reliable method for the estimation of cytidine deaminase (cytidine aminohydrolase; EC 3.5.4.5) activity in pregnancy serum is described. This enzyme does not require magnesium for activation and is also more stable than deoxycytidylate deaminase (dCMP deaminase, dCMP aminohydrolase; EC 3.5.4.12).
D D, Jones, S, Bahijri, E L, Roberts, G F, Williams   +3 more
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Multifaceted antiviral actions of APOBEC3 cytidine deaminases

Trends in Immunology, 2006
To defend against external pathogens, metazoan organisms have evolved numerous defenses that generally fall within the innate and adaptive immune responses. Considerable effort continues to focus on developing a vaccine to manipulate the adaptive immune system to protect against or control HIV-1.
Ya-Lin, Chiu, Warner C, Greene
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Studies on Thermal Stability of Human Cytidine Deaminase

Nucleosides, Nucleotides & Nucleic Acids, 2007
The thermal stability of human cytidine deaminase (CDA), an enzyme involved in pyrimidine metabolism was investigated. With this in view, the residues R68 and Y60, supposed to be involved in the intersubunit interactions and in the catalytic site of CDA, were mutated to glutamine and glycine, respectively.
VINCENZETTI, Silvia, PUCCIARELLI, Stefania, MARIANI P., DE SANCTIS, Giampiero, POLZONETTI, Valeria, NATALINI, Paolo, VITA, Alberto   +6 more
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Recombinant Human Cytidine Deaminase: Expression, Purification, and Characterization

Protein Expression and Purification, 1996
The complementary DNA (cDNA) coding for human cytidine deaminase (CDA) was obtained using two specific primers to screen RNA from peripheral blood polymorphonuclear leukocytes by reverse transcriptase PCR. The cDNA fragment was ligated into the expression vector pTrc99-A and expressed in Escherichia coli following induction with isopropyl-1-thio-beta-D-
Vincenzetti, Silvia, Cambi, Alessandra, Neuhard, Jan, Garattini, Enrico, Vita, Alberto   +4 more
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Gender, Cytidine Deaminase, and 5-Aza/Decitabine—Letter

Clinical Cancer Research, 2013
We have read with interest the observational study by Mahfouz and colleagues ([1][1]), who examined the role of cytidine deaminase (CDA) on outcomes of patients treated with 5-azacytidine or decitabine.
Ciccolini, J., Peters, G.J., Giovannetti, E.   +2 more
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Cytidine deaminase activity inPenicillium politans NRC-510

Journal of Basic Microbiology, 2005
Cell-free extracts of nitrate-grown Penicillium politans NRC-510 catalyzes the hydrolytic deamination of cytidine to uridine. Uridine was chromatographically identified in cell-free extracts. The enzyme exhibited optimum pH and temperature activities at 6.5 and 80 degrees C respectively.
Ali M, Elshafei, Nadia H, Ali, Latifa A, Mohamed   +2 more
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