Results 61 to 70 of about 1,917 (174)

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Study on the relationship between red meat, dietary Neu5Gc intake and anti-Neu5Gc antibody [PDF]

, 2015
唾液酸类化合物是以九碳糖神经氨酸(5-amino-3,5-dideoxy-D-glycero-D-galactononulsonicacid)为基本结构的一族衍生物的总称。目前，已分离和鉴定的有50余种，包括N-乙酰基神经氨酸(N-acetylneuraminicacid,Neu5Ac)、N-羟乙酰基神经氨酸(N-glycoulylneuraminicacid,Neu5Gc)和2－酮基－3－脱氧九酮糖酸(2-keto-3-deoxy-nonulosonicacid,KDN)三种核心单体 ...
范杏丹
core  

Four‐gene Prognostic Signature and Risk of Brain Metastasis of Lung Adenocarcinoma

Molecular Carcinogenesis, Volume 64, Issue 7, Page 1209-1221, July 2025.
ABSTRACT Brain metastasis has a high incidence and poor prognosis in lung adenocarcinoma (LUAD). We sought to identify genes associated with LUAD brain metastasis and with the prognosis of patients with LUAD. Differential gene expression analysis was performed on LUAD patients with and without distant metastasis from the Cancer Genome Atlas (TCGA ...
Zheng Gong, Fengyuan Yu, Chen Li, Bingying Zhao, Miaowei Wen, Shanshan Zhang, Zhezhe Xu, Ailu Wu, Rukun Zang, Yuan Li, Hongwei Li, Yipeng Song   +11 more
wiley   +1 more source

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation

mBio
Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosaccharide (LOS ...
Amaris J. Cardenas, Keena S. Thomas, Mary W. Broden, Noel J. Ferraro, Marcos M. Pires, Constance M. John, Gary A. Jarvis, Alison K. Criss   +7 more
doaj   +1 more source

The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity [PDF]

, 2013
Prokaryote-specific sugars, including N,N′-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity.
Imperiali, Barbara, Morrison, Michael James   +1 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Influence of lipopolysaccharide on proinflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells [PDF]

, 2018
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells.
Chen, Di, Darabad, Raheleh Rahimi, Kam, Wendy R., Liu, Yang, Sahin, Afsun, Sullivan, David A.   +5 more
core   +1 more source

Humoral Barrier to Preclinical and Clinical Xenotransplantation

Xenotransplantation, Volume 32, Issue 3, May/June 2025.
ABSTRACT Xenotransplantation is finally moving toward clinical application. Despite the progress in survival in preclinical models and the limited attempts at clinical heart transplantation, the initial problem of xenoreactive antibodies in human serum remains a proximal barrier to widespread success in preclinical and clinical settings.
A. Joseph Tector, Matt Tector, Sabrina Copsel, Zhang Yu Wang, Chris Burlak, Luz M. Reyes, Jose L. Estrada, Victor Novara Gennuso, Andrew B. Adams   +8 more
wiley   +1 more source

Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs [PDF]

, 2014
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc ...
Burlak, C., Estrada, J., Li, P., Lutz, A. J., Paris, L. L., Sidner, R. A., Tector, A. J., Tector, M.   +7 more
core   +1 more source

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source