The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites [PDF]
IntroductionThe pathogenesis of severe malaria is primarily attributed to the cytoadherence properties of Plasmodium-infected erythrocytes (IRBC), which include rosetting and IRBC-endothelial cytoadherence.
Zhi-Ying Phong+12 more
doaj +4 more sources
Cytoadherence Properties of Plasmodium knowlesi-Infected Erythrocytes [PDF]
Plasmodium knowlesi is responsible for zoonotic malaria infections that are potentially fatal. While the severe pathology of falciparum malaria is associated with cytoadherence phenomena by Plasmodium falciparum-infected erythrocytes (IRBC), information ...
Wenn-Chyau Lee+8 more
doaj +3 more sources
A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum. [PDF]
Immediately after invading their chosen host cell, the mature human erythrocyte, malaria parasites begin to export an array of proteins to this compartment, where they initiate processes that are prerequisite for parasite survival and propagation ...
Küster N+4 more
europepmc +3 more sources
Impact of dengue virus infection on the cytoadherence of Plasmodium vivax-infected erythrocytes. [PDF]
BACKGROUND Coinfections of Plasmodium parasites and the dengue virus have been linked to severe disease in some patients. The interactions between these two pathogens, particularly their effects on disease progression, highlight the clinical importance ...
da Cruz MGS+6 more
europepmc +3 more sources
In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36 [PDF]
Background Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells,
Khairul M. F. Mustaffa+4 more
doaj +7 more sources
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow adhesion assay with TNF‐activated primary human microvascular endothelial cells, we ...
Janet Storm+11 more
doaj +3 more sources
Comparative 1D Blue-Native electrophoresis analysis of Plasmodium falciparum and human proteins associated with cytoadherence. [PDF]
BACKGROUND To understand more about changes to the molecular components that occur when host endothelium interacts with Plasmodium falciparum-infected erythrocytes, a combined technique of protein separation (1D Blue-Native electrophoresis) and mass ...
Al-Harthi, Saeed+3 more
core +7 more sources
Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm [PDF]
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the infected erythrocytes. Cytoadherence plays a central role in the parasite's
Wenn-Chyau Lee+2 more
doaj +3 more sources
PIP2 regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalis. [PDF]
Trichomonas vaginalis is a prevalent causative agent that causes trichomoniasis leading to uropathogenic inflammation in the host. The crucial role of the actin cytoskeleton in T.
Chen YJ+5 more
europepmc +2 more sources
Knobs, Adhesion, and Severe Falciparum Malaria [PDF]
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary ...
Mark F. Wiser
doaj +2 more sources