Results 1 to 10 of about 6,252 (195)

Cytoadherence Properties of Plasmodium knowlesi-Infected Erythrocytes [PDF]

Frontiers in Microbiology, 2022
Plasmodium knowlesi is responsible for zoonotic malaria infections that are potentially fatal. While the severe pathology of falciparum malaria is associated with cytoadherence phenomena by Plasmodium falciparum-infected erythrocytes (IRBC), information ...
Wenn-Chyau Lee, Wenn-Chyau Lee, Shahhaziq Shahari, Samantha Yee Teng Nguee, Samantha Yee Teng Nguee, Yee-Ling Lau, Laurent Rénia, Laurent Rénia, Laurent Rénia   +8 more
doaj   +6 more sources

Knobs, Adhesion, and Severe Falciparum Malaria [PDF]

Tropical Medicine and Infectious Disease, 2023
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary ...
Mark F. Wiser
doaj   +2 more sources

Distinct features of the host-parasite interactions between nonadherent and adherent Trichomonas vaginalis isolates. [PDF]

PLoS Neglected Tropical Diseases, 2023
Cytoadherence of Trichomonas vaginalis to human vaginal epithelial cells (hVECs) was previously shown to involve surface lipoglycans and several reputed adhesins on the parasite.
Hong-Ming Hsu, Yen-Yu Yang, Yu-Hsin Huang, Chien-Hsin Chu, Ting-Jui Tu, Yen-Ting Wu, Chu-Jen Chiang, Shi-Bing Yang, Daniel K Hsu, Fu-Tong Liu, Jung-Hsiang Tai   +10 more
doaj   +2 more sources

An Atypical F-Actin Capping Protein Modulates Cytoskeleton Behaviors Crucial for Trichomonas vaginalis Colonization [PDF]

Microbiology Spectrum, 2023
Cytoadherence and migration are crucial for pathogens to establish colonization in the host. In contrast to a nonadherent isolate of Trichomonas vaginalis, an adherent one expresses more actin-related machinery proteins with more active flagellate ...
Kai-Hsuan Wang, Jing-Yang Chang, Fu-An Li, Kuan-Yi Wu, Shu-Hao Hsu, Yen-Ju Chen, Tse-Ling Chu, Jessica Lin, Hong-Ming Hsu   +8 more
doaj   +2 more sources

A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum. [PDF]

Mol Microbiol
In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Küster N, Roling L, Ouayoue A, Steeg K, Przyborski JM.   +4 more
europepmc   +2 more sources

The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionThe pathogenesis of severe malaria is primarily attributed to the cytoadherence properties of Plasmodium-infected erythrocytes (IRBC), which include rosetting and IRBC-endothelial cytoadherence.
Zhi-Ying Phong, Zhi-Ying Phong, Joo-Yie Chin, Yee Ling Ng, Nurul Izza Zakaria, Siti Nur Athirah-Azman, Siti Nur Athirah-Azman, Varakorn Kosaisavee, Laurent Rénia, Laurent Rénia, Laurent Rénia, Wenn-Chyau Lee, Wenn-Chyau Lee   +12 more
doaj   +2 more sources

Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture. [PDF]

PLoS ONE, 2023
The human malaria parasite Plasmodium falciparum is responsible for the majority of mortality and morbidity caused by malaria infection and differs from other human malaria species in the degree of accumulation of parasite-infected red blood cells in the
Basim Othman, Leo Zeef, Tadge Szestak, Zineb Rchiad, Janet Storm, Caroline Askonas, Rohit Satyam, Aymen Madkhali, Michael Haley, Simon Wagstaff, Kevin Couper, Arnab Pain, Alister Craig   +12 more
doaj   +2 more sources

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis.
Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, Brendan S. Crabb, Brendan S. Crabb, James McCarthy, Paul R. Gilson, Paul R. Gilson   +11 more
doaj   +2 more sources

A preliminary study of the immunogenic response of plant-derived multi-epitopic peptide vaccine candidate of Mycoplasma gallisepticum in chickens [PDF]

Frontiers in Plant Science, 2023
Mycoplasma gallisepticum (MG) is responsible for chronic respiratory disease in avian species, characterized by symptoms like respiratory rales and coughing. Existing vaccines for MG have limited efficacy and require multiple doses.
Susithra Priyadarhni Mugunthan, Divyadharshini Venkatesan, Chandramohan Govindasamy, Dhivya Selvaraj, Harish Mani Chandra   +4 more
doaj   +2 more sources

In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36 [PDF]

Malaria Journal, 2017
Background Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells,
Khairul M. F. Mustaffa, Janet Storm, Megan Whittaker, Tadge Szestak, Alister G. Craig   +4 more
doaj   +7 more sources