Results 11 to 20 of about 6,252 (195)

Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. [PDF]

Malaria Journal, 2012
BACKGROUND: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria.
Ahmed, A, Cox-Singh, J, Craig, AG, Fatih, FA, Krishna, S, Siner, A, Singh, B, Woon, LC   +7 more
core   +13 more sources

Transcriptional responses of brain endothelium to Plasmodium falciparum patient-derived isolates in vitro [PDF]

Microbiology Spectrum
A hallmark of cerebral malaria (CM) is sequestration of Plasmodium falciparum-infected erythrocytes (IE) within the brain microvasculature. Binding of IE to endothelium reduces microvascular flow and, combined with an inflammatory response, perturbs ...
Caroline Askonas, Janet Storm, Grazia Camarda, Alister Craig, Arnab Pain   +4 more
doaj   +2 more sources

Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms [PDF]

Frontiers in Cellular and Infection Microbiology
Cerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting ...
Renato M. S. de Lima, Luana K. R. Leão, Luana C. Martins, Adelaide da C. Fonseca Passos, Evander de J. Oliveira Batista, Anderson M. Herculano, Karen R. H. M. Oliveira   +6 more
doaj   +2 more sources

Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm

Frontiers in Immunology, 2019
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the infected erythrocytes. Cytoadherence plays a central role in the parasite's
Wenn-Chyau Lee, Bruce Russell, Laurent Rénia   +2 more
doaj   +3 more sources

Editorial: Frontiers in malaria research [PDF]

Frontiers in Microbiology, 2023
Ritu Gill, Rachna Hora, Mahmood M. Alam, Abhisheka Bansal, Tarun Kumar Bhatt, Ashwani Sharma   +5 more
doaj   +2 more sources

Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence [PDF]

Memorias do Instituto Oswaldo Cruz, 2012
When grown in the presence of exogenous collagen I, Mycobacterium bovis BCG was shown to form clumps. Scanning electron microscopy examination of these clumps revealed the presence of collagen fibres cross-linking the bacilli.
André Alves Dias, Dominique Raze, Cristiana Soares de Lima, Maria Angela de Melo Marques, Hervé Drobecq, Anne-Sophie Debrie, Michelle Lopes Ribeiro-Guimarães, Franck Biet, Maria Cristina Vidal Pessolani   +8 more
doaj   +6 more sources

Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Frontiers in Molecular Biosciences, 2022
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan, Funmilola Adesodun Fisusi, Olufunso Bayo Adeoye   +2 more
doaj   +1 more source

Computational Insights into the Interaction between Cytoadherence Receptor gC1qR and the DBLβ12 Domain of a Plasmodium falciparum PfEMP1 Ligand

Life, 2021
Human receptor gC1qR is a 32 kD protein that mediates the cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) to human brain microvascular endothelial cells (HBMEC) and platelets.
Rowaida Bakri, Mohd Rehan, Hina Shamshad, Abdul Hafiz   +3 more
doaj   +1 more source

Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool

Bioengineering, 2022
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy.
Amrendra Chaudhary, Poonam Kataria, Neha Surela, Jyoti Das   +3 more
doaj   +1 more source

Parasite virulence factors during falciparum malaria: rosetting, cytoadherence, and modulation of cytoadherence by cytokines [PDF]

Infection and Immunity, 1993
To determine virulence factors of isolates of Plasmodium falciparum and the potential role of cytokines in cerebral malaria, 46 Malagasy patients presenting with cerebral (n = 10), severe (n = 10), and uncomplicated (n = 26) malaria were enrolled in a study. The capacity of 21 of 46 P.
P, Ringwald, F, Peyron, J P, Lepers, P, Rabarison, C, Rakotomalala, M, Razanamparany, M, Rabodonirina, J, Roux, J, Le Bras   +8 more
openaire   +2 more sources