Results 21 to 30 of about 7,415 (242)

Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite [PDF]

Infection and Immunity, 2016
Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity.
Beeson, James G., Chan, Jo-Anne A., Fink, James, Gerrard, John, Good, Michael F., Griffin, Paul M., Hackett, Hazel, Hanssen, Eric, Hoffman, Stephen L., Langer, Christine, Liu, Xue Q., McCarthy, James S., Pingnet, Jolien, Rodriguez, Ingrid B., Sekuloski, Silvana, Stanisic, Danielle I., Sundac, Lana, Trenholme, Katharine R., Wang, Claire Y. T., Yang, Yuedong, Zhou, Yaoqi   +20 more
core   +2 more sources

ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model

Malaria Journal, 2017
Background Parasite cytoadherence within the microvasculature of tissues and organs of infected individuals is implicated in the pathogenesis of several malaria syndromes. Multiple host receptors may mediate sequestration.
Deirdre A. Cunningham, Jing-wen Lin, Thibaut Brugat, William Jarra, Irene Tumwine, Garikai Kushinga, Jai Ramesar, Blandine Franke-Fayard, Jean Langhorne   +8 more
doaj   +3 more sources

Transcriptional responses of brain endothelium to Plasmodium falciparum patient-derived isolates in vitro [PDF]

Microbiology Spectrum
A hallmark of cerebral malaria (CM) is sequestration of Plasmodium falciparum-infected erythrocytes (IE) within the brain microvasculature. Binding of IE to endothelium reduces microvascular flow and, combined with an inflammatory response, perturbs ...
Caroline Askonas, Janet Storm, Grazia Camarda, Alister Craig, Arnab Pain   +4 more
doaj   +2 more sources

Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. [PDF]

Malaria Journal, 2012
BACKGROUND: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria.
Ahmed, A, Cox-Singh, J, Craig, AG, Fatih, FA, Krishna, S, Siner, A, Singh, B, Woon, LC   +7 more
core   +13 more sources

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Nature Communications, 2020
Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen ...
Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne C. G. Almeida, Marcelo A. M. Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borràs, Eduard Sabidó, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra, Hernando A. del Portillo   +30 more
doaj   +2 more sources

Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence [PDF]

mBio, 2016
Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected erythrocytes (IRBC) in vital organs, including the brain, with resulting impairment of blood ...
Mark R. Gillrie, Bernard Renaux, Eleanor Russell‐Goldman, Marion Avril, Andrew J. Brazier, Koichiro Mihara, Enrico Di, Danny A. Milner, Morley D. Hollenberg, Joseph D. Smith, May Ho   +10 more
openalex   +2 more sources

Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence [PDF]

Memorias do Instituto Oswaldo Cruz, 2012
When grown in the presence of exogenous collagen I, Mycobacterium bovis BCG was shown to form clumps. Scanning electron microscopy examination of these clumps revealed the presence of collagen fibres cross-linking the bacilli.
André Alves Dias, Dominique Raze, Cristiana Soares de Lima, Maria Angela de Melo Marques, Hervé Drobecq, Anne-Sophie Debrie, Michelle Lopes Ribeiro-Guimarães, Franck Biet, Maria Cristina Vidal Pessolani   +8 more
doaj   +2 more sources

Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms [PDF]

Frontiers in Cellular and Infection Microbiology
Cerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting ...
Renato M. S. de Lima, Luana K. R. Leão, Luana C. Martins, Adelaide da C. Fonseca Passos, Evander de J. Oliveira Batista, Anderson M. Herculano, Karen R. H. M. Oliveira   +6 more
doaj   +2 more sources

Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily [PDF]

Microorganisms, 2022
Vivax malaria, caused by Plasmodium vivax, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to Plasmodium falciparum, P.
Youn-Kyoung Goo
doaj   +2 more sources

Automated counting for Plasmodium falciparum cytoadherence experiments. [PDF]

Malaria Journal, 2011
The automated counting programs are an accurate and practical way of quantifying static parasite binding assays to purified proteins. They are less accurate when applied to cell based systems, but can still provide a reasonable level of accuracy to give ...
Barrett, Steve D., Craig, Alister, Faragher, Brian, Mustaffa, Khairul, Paton, Douglas, Szestak, Tadge   +5 more
core   +8 more sources