Results 61 to 70 of about 42,571 (229)

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, EarlyView.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Perfluorooctanesulfonamide-induced epiboly delay is associated with decreased ATP production within zebrafish embryos

Ecotoxicology and Environmental Safety
Per- and polyfluoroalkyl substances (PFAS) persistence within environmental media has led to ubiquitous exposure within humans and wildlife. We previously found that exposure of zebrafish embryos to perfluorooctanesulfonamide (PFOSA) from 0.75 to 6 h ...
John Hoang, Nicholas Jimenez, Keivon Faizi, Qibo Xiang, Emma Fencl, Rebecca Yates, Jay Gan, David C. Volz   +7 more
doaj   +1 more source

Cariopathologic changes in human binuclear and mononuclear T-cells under the influence of cytochalasin B and lead chloride in vitro

Бюллетень сибирской медицины, 2005
The influence of PbCl2 on PHA-stimulated culture of human¢s T-cells was analyzed in the investigation. The number of mitotic cells was increased in cultures with PbCl2.
M. S. Romanova, N. N. Ilyinskikh, A. G. Semenov   +2 more
doaj   +1 more source

Fusion of isolated myoblast plasma membranes [PDF]

, 1978
Fusion of plasma membranes isolated from myoblasts grown in culture has been investigated. 1. 1. Membrane fusion was specifically dependent on Ca2+ at physiological concentrations. However, at higher concentrations of cations, fusion could be triggered
Ahkong, Batzri, Berl, Berlin, Burwen, Croce, Dahl, Dahl, Dahl, De Camilli, Douglas, Dreifuss, Fairbanks, Gratzl, Gratzl, Gratzl, Hauser, Holtzer, Kalderon, Kantor, Kent, Lawson, Lee, Maeda, Martin, Okada, Okada, Onishi, Orci, Pagano, Papahadjopoulos, Papahadjopoulos, Papahadjopoulos, Papahadjopoulos, Pauli, Peretz, Poole, Poste, Prives, Rash, Reed, Reeves, Sanger, Satir, Schimmel, Schlessinger, Schudt, Schudt, Schudt, Schudt, Shainberg, Shainberg, Van den Bosch, Van den Bosch, Van den Bosch, Vos, Weidekamm, Weidekamm, Yanofsky, Zakai   +59 more
core   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Impact of phenylpropanoid compounds on heat stress tolerance in carrot cell cultures [PDF]

, 2016
The phenylpropanoid and flavonoid families include thousands of specialized metabolites that influence a wide range of processes in plants, including seed dispersal, auxin transport, photoprotection, mechanical support and protection against insect ...
Baldan, Barbara, Ceoldo, S, Commisso, M, Guzzo, F., Levi, M, Stocchero, M, Strazzer, P, Toffali, K   +7 more
core   +3 more sources

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans, Van Renne, Nicolaas, Wei, Ruifang   +2 more
core   +1 more source

Nanoplastics: From tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination [PDF]

, 2020
Plastic litter is an issue of global concern. In this work Mytilus galloprovincialis was used to study the distribution and effects of polystyrene nanoplastics (PS NPs) of different sizes (50 nm, 100 nm and 1 mu m) on immune cells.
Figueras, A., Novoa, B., Romero, A., Saco, A., Sendra, M., Yeste Sigüenza, María del Pilar   +5 more
core   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source