Results 71 to 80 of about 25,429 (197)

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum

Marine Drugs, 2019
Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (1‒3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses ...
Yang Cheng, Atallah F. Ahmed, Raha S. Orfali, Chang-Feng Dai, Jyh-Horng Sheu   +4 more
doaj   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

The LAV‐BPIFB4‐Platelet‐CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Elena Ciaglia, Roberta Maria Esposito, Valentina Lopardo, Francesco Montella, Cristina Basile, Roberta Longo, Anna Maciag, Giuseppe Rescigno, Antonio Damato, Francesco Del Plato, Alfonso Finizio, Carmine Vecchione, Albino Carrizzo, Annibale Alessandro Puca   +13 more
wiley   +1 more source

Comparison Of The Effect Of Cytochalasin B And Paclitaxel (Taxol Tm) On Cryopreservation Of Icr Mouse Oocytes

Taiwanese Journal of Obstetrics & Gynecology, 2005
Objective: To investigate the benefits of the cytoskeleton stabilizers paclitaxel and cytochalasin B (CCB) in the oocyte vitrification procedure. Materials and Methods: ICR mice aged 4-6 weeks were superovulated with pregnant mare serum gonadotropin and ...
Po-Ning Lee, Shao-Ping Weng, Yiu-Tai Li, Cheng-Tsung Kuo   +3 more
doaj   +1 more source

Cytochalasin B Influences Cytoskeletal Organization and Osteogenic Potential of Human Wharton's Jelly Mesenchymal Stem Cells. [PDF]

Pharmaceuticals (Basel), 2023
Pampanella L, Abruzzo PM, Tassinari R, Alessandrini A, Petrocelli G, Ragazzini G, Cavallini C, Pizzuti V, Collura N, Canaider S, Facchin F, Ventura C.   +11 more
europepmc   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, Volume 178, Issue 3, Page 417-427, July 2026.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Necdin and neuronatin genes expression among diploid parthenogenetic, IVF and in vivo derived female sexed embryos during preimplantation development in goat

Indian Journal of Animal Sciences, 2014
The present research work was undertaken to compare the expression of necdin (Ndn) and neuronatin (Nnat) genes among diploid parthenogenetic (DIP), female sexed in vivo and female sexed in vitro produced embryonic cell colony.
R RANJAN, RENU SINGH, KULDEEP KUMAR, M SARKAR, B C DAS, SADHAN BAG   +5 more
doaj   +1 more source

Mitochondrial aggregation caused by cytochalasin B compromises the efficiency and safety of three-parent embryo. [PDF]

Mol Hum Reprod, 2022
Li Y, Shi S, Yuan J, Xiao X, Ji D, Pan J, Min Z, Wang H, Sha H, Ji Y.   +9 more
europepmc   +1 more source