, 2018 One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two ...
Vanessa Mara Chapla +8 more
openalex +2 more sources
Novel Metabolites from the Marine-Derived Fungus Peniophora sp. SCSIO41203 Show Promising In Vitro Antitumor Activity as Methuosis Inducers in PC-3 Cells [PDF]
Marine DrugsTwo new cytochalasin derivatives, peniotrinins A (1) and B (2), three new citrinin derivatives, peniotrinins C–E (4, 5, 7), and one new tetramic acid derivative, peniotrinin F (12), along with nine structurally related known compounds, were isolated from
Bin Yang +9 more
doaj +2 more sources
Neglected Tropical Diseases: A Chemoinformatics Approach for the Use of Biodiversity in Anti-Trypanosomatid Drug Discovery [PDF]
BiomoleculesThe development of new treatments for neglected tropical diseases (NTDs) remains a major challenge in the 21st century. In most cases, the available drugs are obsolete and have limitations in terms of efficacy and safety.
Marilia Valli +5 more
doaj +2 more sources
Cytochalasins Suppress 3D Migration of ECM-Embedded Tumoroids at Non-Toxic Concentrations. [PDF]
Int J Mol SciBeslmüller K +7 more
europepmc +3 more sources
NQO1-responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell-targeted Migrastatic
Small, EarlyView.The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho +7 more
openalex +2 more sources
New polyketides from the liquid culture of Diaporthe breyniae sp. nov. (Diaporthales, Diaporthaceae) [PDF]
MycoKeys, 2022 During the course of a study on the biodiversity of endophytes from Cameroon, a fungal strain was isolated. A multigene phylogenetic inference using five DNA loci revealed that this strain represents an undescribed species of Diaporthe, which is ...
Blondelle Matio Kemkuignou +6 more
doaj +3 more sources
Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B
Natural Product Research, 2022 Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis.
Zhaolong Xu +6 more
semanticscholar +1 more source
Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]
, 2013 Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig +5 more
core +11 more sources
Frontiers in Microbiology, 2020 Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition, differential ...
Bruno Perlatti +6 more
doaj +1 more source
Diversely Functionalised Cytochalasins through Mutasynthesis and Semi‐Synthesis
Chemistry, 2020 Mutasynthesis of pyrichalasin H from Magnaporthe grisea NI980 yielded a series of unprecedented 4′‐substituted cytochalasin analogues in titres as high as the wild‐type system (≈60 mg L−1).
Chongqing Wang +9 more
semanticscholar +1 more source