Results 11 to 20 of about 391,026 (214)
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source
Nitrogen-Vacancy Magnetic Relaxometry of Nanoclustered Cytochrome C Proteins [PDF]
Nano Letters 24, 3, 873-880, 2024, 2023 Nitrogen-vacancy (NV) magnetometry offers an alternative tool to detect paramagnetic centers in cells with a favorable combination of magnetic sensitivity and spatial resolution. Here, we employ NV magnetic relaxometry to detect cytochrome C (Cyt-C) nanoclusters.
arxiv +1 more source
TOF-SIMS structural characterization of self-assembly monolayer of cytochrome b5 onto gold substrate [PDF]
Applied Surface Science 255 (2008) 1071-74, 2010 Orientation and three-dimensional structure of immobilized proteins on bio-devices are very important to assure their high performance. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is able to analyze upper surface of one layer of molecules.
arxiv +1 more source
Kinetics of proton pumping in cytochrome c oxidase [PDF]
J. Chem. Phys. 130, 235105 (2009), 2008 We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme.
arxiv +1 more source
Catching proteins in liquid helium droplets [PDF]
Phys. Rev. Lett. 105, 133402 (2010), 2010 An experimental approach is presented that allows for the incorporation of large mass/charge selected ions in liquid helium droplets. It is demonstrated that droplets can be efficiently doped with a mass/charge selected amino acid as well as with the much bigger m$\approx$12 000 amu protein Cytochrome C in selected charge states.
arxiv +1 more source
Targeting cytochrome C oxidase in mitochondria with Pt(II)-porphyrins for Photodynamic Therapy [PDF]
, 2010 Mitochondria are the power house of living cells, where the synthesis of the chemical "energy currency" adenosine triphosphate (ATP) occurs. Oxidative phosphorylation by a series of membrane protein complexes I to IV, that is, the electron transport chain, is the source of the electrochemical potential difference or proton motive force (PMF) of protons
arxiv +1 more source
Portosystemic hepatic encephalopathy model shows reversal learning impairment and dysfunction of neural activity in the prefrontal cortex and regions involved in motivated behavior [PDF]
Journal of Clinical Neuroscience (2011)18(5):690-4, 2011 Hepatic encephalopathy is a neurological complication that affects attention and memory. Experimental animal models have been used to study hepatic Encephalopathy, the most frequent being the portacaval shunt. In order to determine learning impairment and brain functional alterations in this model, we assessed reversal learning and neural metabolic ...
arxiv +1 more source
Protein Adsorption into Mesopores: A Combination of Electrostatic Interaction, Counterion Release and van der Waals Forces [PDF]
Langmuir 30, 2729-2737 (2014), 2015 Bovine heart cytochrome c has been immobilized into the mesoporous silica host material SBA-15 in both its native folded and urea-unfolded state. The comparison of the two folding states' behavior casts doubt on the commonly used explanation of cytochrome c adsorption, i.e. the electrostatic interaction model.
arxiv +1 more source
Reliably assessing the electronic structure of cytochrome P450 on today's classical computers and tomorrow's quantum computers [PDF]
, 2022 An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to deploy these future devices. In order to perform this assessment reliably, quantum resource estimates must be coupled with classical simulations attempting to answer relevant ...
arxiv +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source