Results 11 to 20 of about 630,553 (340)

Cytochrome P450 Enzymes and Drug Metabolism in Humans

International Journal of Molecular Sciences, 2021
Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination
Mingzhe Zhao, Jingsong Ma, Mo Li, Yingtian Zhang, Bixuan Jiang, Xiang-Yun Zhao, Cong Huai, Lu Shen, Na Zhang, Lin He, Shengying Qin   +10 more
semanticscholar   +1 more source

Phylogenetic incongruence inferred with two mitochondrial genes in Mepraia spp. and Triatoma eratyrusiformis(Hemiptera, Reduviidae)

Genetics and Molecular Biology, 2015
Mitochondrial DNA (mtDNA) is widely used to clarify phylogenetic relationships among and within species, and to determine population structure. Due to the linked nature of mtDNA genes it is expected that different genes will show similar results ...
Ricardo Campos-Soto, Fernando Torres-Pérez, Aldo Solari   +2 more
doaj   +1 more source

Mitochondrial cytochrome <em>B</em> sequence divergence among Spanish, Alpine and Abruzzo chamois (genus <em>Rupicapra</em>)

Hystrix, the Italian Journal of Mammalogy, 1998
<strong>Abstract</strong> We have studied genetic divergence and phylogenetic relationships of Alpine, Spanish and Abruzzo chamois (genus <em>Rupicapra</em>) by sequencing a region of 330 nucleotides within the mitochondrial DNA ...
Nadia Mucci, Ettore Randi, Leonardo Gentile, Franco Mari, Maurizio Locati   +4 more
doaj   +1 more source

Geobacter Protein Nanowires

Frontiers in Microbiology, 2019
The study of electrically conductive protein nanowires in Geobacter sulfurreducens has led to new concepts for long-range extracellular electron transport, as well as for the development of sustainable conductive materials and electronic devices with ...
Derek R. Lovley, David J. F. Walker
doaj   +1 more source

Functionalization of Bacterial Microcompartment Shell Proteins With Covalently Attached Heme

Frontiers in Bioengineering and Biotechnology, 2020
Heme is a versatile redox cofactor that has considerable potential for synthetic biology and bioelectronic applications. The capacity to functionalize non-heme-binding proteins with covalently bound heme moieties in vivo could expand the variety of ...
Jingcheng Huang, Jingcheng Huang, Bryan H. Ferlez, Bryan H. Ferlez, Eric J. Young, Eric J. Young, Cheryl A. Kerfeld, Cheryl A. Kerfeld, Cheryl A. Kerfeld, David M. Kramer, David M. Kramer, Daniel C. Ducat, Daniel C. Ducat   +12 more
doaj   +1 more source

Specialization of the Reiterated Copies of the Heterodimeric Integration Host Factor Genes in Geobacter sulfurreducens

Frontiers in Microbiology, 2021
Integration host factor (IHF) is a widely distributed small heterodimeric protein member of the bacterial Nucleoid-Associated Proteins (NAPs), implicated in multiple DNA regulatory processes.
Angel Andrade, Angel Andrade, Alberto Hernández-Eligio, Alberto Hernández-Eligio, Ana Lilia Tirado, Leticia Vega-Alvarado, Maricela Olvera, Enrique Morett, Katy Juárez   +8 more
doaj   +1 more source

Gibberellin and auxin production by plant root-fungi and their biosynthesis under salinity-calcium interaction

Plant, Soil and Environment, 2002
Rhizosphere and rhizoplane of fababean (Vicia faba), melochia (Corchorus olitorius), sesame (Sesamum indicum) and soyabean (Glycine max) plants are inhabited with fungi, mostly Aspergillus flavus, A. niger, Fusarium oxysporum, Penicillium corylophilum, P.
H.A.H. Hasan
doaj   +1 more source

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

mSphere, 2019
Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis.
Gregory A. Harrison, Anne E. Mayer Bridwell, Megh Singh, Keshav Jayaraman, Leslie A. Weiss, Rachel L. Kinsella, Janessa S. Aneke, Kelly Flentie, Miranda E. Schene, Margaret Gaggioli, Samantha D. Solomon, Scott A. Wildman, Marvin J. Meyers, Christina L. Stallings   +13 more
doaj   +1 more source

Exploring oxidative stress pathways in Geobacter sulfurreducens: the redox network between MacA peroxidase and triheme periplasmic cytochromes

Frontiers in Microbiology, 2023
The recent reclassification of the strict anaerobe Geobacter sulfurreducens bacterium as aerotolerant brought attention for oxidative stress protection pathways.
Pilar C. Portela, Pilar C. Portela, Leonor Morgado, Leonor Morgado, Marta A. Silva, Marta A. Silva, Lukas Denkhaus, Oliver Einsle, Carlos A. Salgueiro, Carlos A. Salgueiro   +9 more
doaj   +1 more source

Cytochrome p-450 polymorphisms and response to clopidogrel.

New England Journal of Medicine, 2009
BACKGROUND Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function.
J. Mega, S. Close, S. Wiviott, Lei-Bin Shen, R. Hockett, J. Brandt, J. Walker, E. Antman, W. Macias, E. Braunwald, M. Sabatine   +10 more
semanticscholar   +1 more source